The department of Cell Biology-Inspired Tissue Engineering (cBITE) at the MERLN Institute for Technology-inspired Regenerative Medicine at Maastricht University in the Netherlands invites applications for a post-doctoral position. The post-doctoral researcher will perform cutting-edge research in computational modeling methods applied to regenerative medicine and more specifically, to kidney toxin transport in microfluidic set-ups, organoid culture systems and/or bioartificial kidney devices.

JOB DESCRIPTION

Regenerative medicine holds the promise to cure many of what are now chronic patients, restoring health rather than protracting decline, bettering the lives of millions and at the same time preventing lifelong, expensive care processes: cure instead of care. More specifically, at present, dialysis and transplantation are the only treatment options for end-stage kidney disease. In the Netherlands alone, 6,500 people currently depend on dialysis, approximately 1,300 of which will die this year. Regenerative medicine offers an alternative treatment in the form of a bioengineered kidney. As a first step, the partners of RegMed XB will work towards creating a functional subunit of a bioengineered kidney. This functional subunit is the nephron, of which there are approximately one million in the adult kidney. In order to inform the in vitro experiments as well as design a bioartificial kidney as an intermediate step towards a fully bioengineered kidney, this project will use computational models to simulate toxin transport and calculate the flow and geometry requirements for adequate toxin removal in various set-ups: microfluidic, organoid culture systems and bioartificial devices.

Project description:

• Computational modeling of toxin transport, computational fluid dynamics, to inform the design of in vitro kidney organoid experiments and/or bioartificial kidney devices
• Parameter optimization and sensitivity analysis
• Analysis and integration of various in vitro/in vivo data for model calibration

What we offer:

• Computational ecosystem at Maastricht University: Institute for Data Science (IDS), Department of Knowledge Engineering (DKE) and Maastricht Centre for Systems Biology (MacsBio)
• Excellent computational and experimental facilities to validate the in silico analyses and predictions in vitro/in vivo
• Interdisciplinary environment within MERLN and the RegMed XB consortium

Project embedding:

The project will be coordinated by the MERLN Institute for Technology-Inspired Regenerative Medicine (http://merlninstitute.com/) at Maastricht University (UM), while closely collaborating with TU Eindhoven, Utrecht University and Leiden University as part of RegMed XB, which stands for “Regenerative Medicine Crossing Borders”. RegMed XB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. RegMed XB is best-suited for those scientists who are driven to make a difference in the lives of patients and who wish to join a growing initiative that promises to integrate entrepreneurial activities with the excellent scientific research performed within the universities. Joining RegMed XB means being part of a community working on research programs aimed to cure a chronic disease (for more information, please visit www.regmedxb.com).

REQUIREMENTS

Requirements and key expertise

• PhD in data science, computer science, statistics, mathematics, bioinformatics, biomedical informatics, artificial intelligence, or equivalent
• Demonstrated ability to work independently as well as in a team
• Strong scientific background and publication record
• Expertise in computational modeling, computational fluid dynamics
• Good programming skills (for example Comsol, Matlab, Python, R, VCell)\
• Basic knowledge of image processing and analysis
• Affinity with regenerative medicine
• Good oral and written English communication

CONDITIONS OF EMPLOYMENT

Fixed-term contract: 1 year.

The position is temporary for the duration of the project (12 months). Depending on experience and qualification, the gross monthly salary is scale 10 (max. € 4.402,-), based on a full-time appointment.

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl > Support > UM employees.

EMPLOYER

Maastricht University

Maastricht University (UM) is the most international university in the Netherlands and, with more than 18,000 students and 4,400 employees, is still growing. The university stands out for its innovative education model, international character and multidisciplinary approach to research and education. Thanks to its high-quality research and study programs as well as a strong focus on social engagement, UM has quickly built up a solid reputation. Today it is considered one of the best young universities in the world

DEPARTMENT

MERLN Institute

The MERLN Institute for Technology-inspired Regenerative Medicine focuses on developing novel and challenging technologies to advance the field of tissue and organ repair and regeneration through, amongst others, the development of high-throughput material platforms to screen cell-biomaterial interactions. MERLN consists of an interdisciplinary team of researchers including fields as (stem cell) biology, materials engineering, chemistry, micro/nanofabrication, additive manufacturing, etc. The scientists at MERLN have an extensive network of collaborators within research institutions in and outside the Netherlands as well as with a number of biomedical companies, including their own spin-off companies, as entrepreneurship is highly fostered.

ADDITIONAL INFORMATION

The application should contain:

• Cover letter with motivation, fit and preferred starting date
• Statement of research interests and accomplishments, max 2 pages
• CV including a list of publications
• Contact information of two references

For more detailed information you can contact dr. A. Carlier: a.carlier@maastrichtuniversity.nl.

More details:

https://www.academictransfer.com/en/292752/postdoc-computational-modeling-of-kidney-toxin-transport/

Published: 2020-01-20

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Division for Applied Materials Science, Department of Materials Science and Engineering, the Ångström Laboratory.

The position is for two years starting as soon as possible. 

Tasks: The overarching goal is to evaluate different implant materials for spinal applications, and in particular their suitability for treatment of vertebrae and intervertebral discs.Mainly numerical methods will be used, such as finite element analysis, although some experimental work also will take place. A natural part of the work lies in reporting results, both in scientific journals and at conferences. The project is funded by the EU, and in particular EIT Health.

Qualifications required: To qualify for an employment as a post-doctor, the applicant must hold a PhD degree or a foreign qualification deemed equivalent to a PhD, and the PhD degree must have been obtained no more than three years prior to the application date; however, for example, periods of sick leave or parental leave are deducted from the three-year period.

For this position a PhD degree in engineering physics, mechanical engineering, biomedical engineering, or similar in nearby subjects, is required.

An interest in numerical modelling is a requirement, and experience in biomedical engineering is an advantage. The ability to lead and advance projects, as well as collaborative skills, is important.

Very good written and verbal skills in English is a must.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

For further information about the position please contact Professor Cecilia Persson, Cecilia.persson@angstrom.uu.se.

Salary: Individually negotiated salary.

Starting date: As soon as possible.

Type of position: Temporary position for two years.

You are welcome to submit your application no later than February 14 2020, UFV-PA 2019/4623. 

In case of disagreement between the English and the Swedish version of this announcement, the Swedish version takes precedence.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Please do not send offers of recruitment or advertising services.

Submit your application through Uppsala University´s recruitment system. More details:

https://www.uu.se/en/about-uu/join-us/details/?positionId=311258

Project information:

The “Birdsong for Human(e) voices” project is funded by the CRI and is led by Dr. Pauline Provini. More information on the project: https://projects.cri-paris.org/projects/tY6OqgWS/summary

Job Description Summary:

We are searching for a highly motivated, independent, multidisciplinary postdoctoral researcher to be part of a team focusing on understanding the biomechanics of birdsong. The postdoctoral researcher will play a substantive role in planning and conducting research by using quantitative modelling methods. In close collaboration with the Principal Investigator, the postdoctoral researcher will

• Participate to the collection of experimental data (multiple X-ray and light high-speed videos, Particle Image Velocimetry data, acoustic data, etc.) of different species of birds during vocalization.
• Fluid dynamics analysis (CFD model) of bird vocalization.
• Aero-acoustic modelling of birdsong based on experimental data collected by the team.
• Draft and publish scientific papers derived from the data.
• Attend annual scientific meetings to present research derived from the project research.
• Actively participate to meetings, seminars, and CRI life in general.

Minimum Qualifications:

PhD qualification with relevant research experience in biomechanics (e.g. engineering, modelling) or a closely related field.

Additional positive qualifications:

Specific expertise in one or more of the targeted experimental techniques (PIV, XROMM, and acoustic recordings), experience with live animals, and knowledge of the functional morphology of vertebrates are considered as additional positive elements for the candidate. An interdisciplinary background is highly appreciated.

Typical Hiring Range: Full-Time job ±2200 Euro/month (net) according to the INSERM salary scale.

Location: Centre de Recherche Interdisciplinaire, 8bis Rue Charles V, 75004 Paris France.

Institution information:

The Center for Research and Interdisciplinarity (CRI) experiments and spreads new ways of learning, teaching, conducting research and mobilizing collective intelligence in life, learning and digital sciences. The CRI promotes scientists who thrive in dynamic environments, are inspired and motivated by daily interactions with diverse peers, work best in teams and comfortably mix disciplines, rearranging, straddling field boundaries and wish to explore uncharted domains.

Job Open/Close Date: Fall 2020/ Summer 2022.

Required Documents

To apply for the position, please send the following documents to Pauline.provini@cri-paris.org:

1. Curriculum Vitae
   1. Cover letter summarizing research interests, professional experience, and career goals.
   1. Names and Contact Information for References

Please have 2 recommendations forwarded directly to Dr. Pauline Provini email address by those individuals providing the references. These should not come from the applicant.

Review of applications will begin on September 15th and continue until the position is filled.

In the context of several National and International Grants, we are seeking two outstanding Post-Doc researchers and/or motivated post-graduate Research Assistants to join us in developing new wearable devices, systems, and data analysis tools for physiological and physical activities monitoring.

The ideal candidate should have the following expertise:
– Relevant publications in international journals and experience in fundraising
– Fluent English is essential
– Excellent interpersonal skills including team working and a collegiate approach. Self-motivation, initiative, and independent thought/working.
– Proficient in MATLAB, Python, C, C++ programming
– Experience in one or more of the following topics:

1. Wearable systems design and development, encompassing electronic design, assembly and testing, microcontroller-based programming.
2. Body Sensor Networks
3. Real-time data acquisition and processing and related algorithms
4. Experimental protocols on human subjects

We will appreciate if you could send your interest to apply by email to E. Schena (e.schena(AT)unicampus.it), D. Formica (d.formica(AT)unicampus.it) and C. Massaroni (c.massaroni(AT)unicampus.it), including a motivation letter detailing how your research profile relate to the project and a CV.

Employment type: Fixed-term contract for 6 months

Interview date: 28 March 2019

We are seeking to appoint a Senior Research Associate (SRA) to contribute to the project “3D printing of complex scaffolds for the repair of osteochondral defects” developed in collaboration between the Biomaterials and Drug Delivery group (http://www.port.ac.uk/school-of-pharmacy-and-biomedical-sciences/research/biomaterials-and-drug-delivery/) and the Zeiss Global Centre (http://www.port.ac.uk/school-of-engineering/zeiss-global-centre/) at the University of Portsmouth.

Osteochondral lesions are painful, and predispose to osteoarthritis (OA), which is unquestionably one of the most important chronic health issues in humans, affecting an estimated 8.5 million people in the UK only. Due to the absence of vascularisation in cartilage, its regenerative capacity is limited, and treatment is required for repair. Severe limitations of current treatments, such as microfracture and autografts, have inspired research into more effective tissue engineering strategies, involving the implantation of stem cells able to repair the tissue. The implanted stem cells must be able to differentiate both into cartilage and bone cells. The differentiation of the cells can be controlled by changes in the modulus of the implant; however, there are no current scaffold materials that allow this concurrent double differentiation. We therefore propose to use our state of the art 3D bioprinter (Cellink) – able to co-print multiple materials and cells – to develop complex structures of biocompatible polymers of selected stiffness and porosity, to study how architectural and mechanical properties of the scaffold guide cells differentiation into the two types of cells desired.

The successful candidate will have a PhD degree or equivalent with experience in tissue culture in particular with stem cells, knowledge of some of the following areas is desirable: bioengineering, mechanobiology, x-ray/confocal microscopy, mechanical testing, 3D printing and biomaterial formulation. The SRA will work in a dynamic environment and benefit from the existing collaborative research between Dr Marta Roldo (expert in the synthesis, formulation and characterisation of biocompatible materials), Dr Petko Petkov (expert in mechanical and design engineering required to adapt the 3D printing process to the higher complexity of bio 3D printing) and Dr Gianluca Tozzi (X-ray computed tomography and correlative imaging).

The post is based at the School of Pharmacy and Biomedical Science, University of Portsmouth, with the appointment effective as soon as possible or no later than 1st April 2019. For informal enquiries please contact Dr Marta Roldo at marta.roldo@port.ac.uk or phone +44 (0)23 9284 3586.

webpage for applications:

https://www.jobs.ac.uk/job/BQH756/senior-research-associate

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, Oxford

More details and applications: