ESBiomech25 Congress in Zurich

New 4-year PDRA position @ University of Glasgow

deadline 11th July 2024

The University of Glasgow is offering a unique opportunity for a Research Associate to make a leading contribution to the Centre for Future Percutaneous Coronary Intervention Planning.  The vision of the Centre is to develop novel and robust mathematical and statistical methodologies, supported by large clinical data sets, to create computational tools for optimisation of cardiovascular procedures. Based within the James Watt School of Engineering, you will work closely with colleagues from Mathematics & Statistics, Cardiovascular & Metabolic Health and Politecnico di Torino, as well as several leading international clinical centres and medical devices/imaging companies. 

You will work on the development of a range of mathematical models and their numerical solution, covering areas including patient geometry reconstruction, fluid-structure interaction, soft tissue mechanics, growth and remodelling and multiphysics modelling. You should have a PhD, or have equivalent experience, in Applied Mathematics, Physics, Computational Engineering, or a related discipline. You should have theoretical and practical knowledge of building multiphysics mathematical models and numerically solving them. Experience in patient geometry reconstruction from medical imaging, soft tissue mechanics and fluid-structure interaction modelling would be desirable.

You will also be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow.

For more details on the vacancy (147648) and to apply,  please visit the university webpage here: https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=147648

Informal enquiries about the role are welcomed, and should be addressed to Dr Sean McGinty, sean.mcginty@glasgow.ac.uk

Join the VMHTsOP project!

Four Research positions available at Insigneo (University of Sheffield) to join the “Virtual Mouse and Human Twins for optimising Treatments for Osteoporosis (VMHTsOP)” project!
The VMHTsOP project aims at developing the first inter-species Virtual Mouse-Human Twin for predicting bone adaptation over time and optimise biomechanical and/or pharmacological treatments for Osteoporosis. It is a 5 years project that will start in September 2024, led by Prof Enrico Dall’Ara at the University of Sheffield, Division of Clinical Medicine and Insigneo institute. The project has been selected by ERC-consolidator grant and funded by the EPSRC through the EU Guarantee fund.
Don’t miss the opportunity to join the team for this exciting research project!


Current Available Positions:
Research Associate (PostDoc) in “Preclinical musculoskeletal imaging and biomechanics”; 3yrs; start in Sep 2024; closing date applications 4th June 2024
Research Associate (PostDoc) in “Computational musculoskeletal biomechanics”; 3yrs; start in Sep 2024; closing date applications 4th June 2024
Research Technician with expertise in imaging and histology; 3yrs; start in Sep 2024; closing date applications 4th June 2024
PhD student in “A biochemo-mechano multi-scale computational model to predict bone adaptation over space and time”; salary and fees (for UK students) for 3.5yrs; start in Oct 2024; closing date applications 10th June 2024
For any enquiries, please contact Prof Enrico Dall’Ara at e.dallara@sheffield.ac.uk


Summary of the project
Eighty per cent of pharmaceutical interventions fail in patients even after being successful in animal studies. Musculoskeletal (MSK) diseases such as osteoporosis (OP) reduce dramatically the quality of life of millions of affected patients. Mice are the most common animal model to test new treatments. Nevertheless, the extrapolation of their effect onto patients and the identification of which new treatments should be tested in clinical studies is based on simple scaling approaches.
In this project we will develop a new mechanistic computational framework that bridges between mouse and human, informed by in vivo experiments in mice, to discover optimal treatments in patients. We will create two parallel virtual mouse and human twins (VMHTs-OP), based on similar inputs (biomedical images, cell data, gait data) that will predict bone adaptation in function of biomechanical and/or biochemical stimuli. Each virtual twin will be based on advanced multi-scale computational models (multi-body dynamics, finite element and cell-population models) to predict bone adaptation over time and space due to OP and to new biomechanical and pharmacological treatments, identifying in silico the new combined treatments that are likely to be effective in patients, to be tested in future clinical trials.
The models will be going through a comprehensive verification, validation and uncertainties quantification process in order to provide the required credibility for future preclinical applications. The model predictions will be validated against longitudinal mouse experiments and available longitudinal clinical data from known biomechanical or pharmacological interventions. Finally, the validated framework will be used to test in silico several combinations of treatments regimens (overlap, intermitted, drug holidays) and different interventions (microgravity, high strain exercises) that would not be ethically nor economically testable in animal and clinical trials.

Postdoc-Position in Biofabrication @Clausthal University of Technology

The Institute for Materials Science and Engineering at Clausthal University of Technology is pleased to announce a postdoctoral position available for one + three years (1+3 years) which we wish to fill as soon as possible. We welcome applications from individuals who are motivated, enthusiastic, and collaborative, demonstrating a commitment to developing solutions for pressing global challenges. The salary scale for this position is EG 13 TV-L aligning with the German collective labour agreement (indicative gross monthly salary range is €4,188.00 – €6,037.00 depending on experience). This opportunity is suitable for part-time work and is crafted as a qualification position for early career postdocs. However, we encourage outstanding candidates, including those without a PhD, to explore the opportunity to pursue a doctorate at Clausthal University of Technology.

The Institute for Materials Science and Engineering at Clausthal University of Technology has a strong application focus in Research and Teaching. The working group Digitalisation in Materials Science and Engineering has a focus on biologic, architectured materials and engineered living materials. The prospective candidate should strengthen this area so that we seek a candidate with a background or interest in biological tissues.

In year one, the successful candidate will support development of an EU consortium application. This includes the opportunity to start up their own research along an existing project which will commence in full from year two onwards with research in microfluidic devices, biofabrication, and bioprinting. You will find key duties, a description of your profile, what we offer, contact details, and how you can apply under https://s.gwdg.de/ECbRA8. We review applications on an ongoing basis and close this advert as soon as we have found a suitable candidate. Please do not hesitate to contact us if you have any questions. We look forward to hearing from you!

More information:

Post-doctoral position on “Bone behavior around a self-tapping dental implant during its insertion, analysed through synchrotron radiation-based fast computed tomography” @INSA Lyon

INSA Lyon is inviting applications for a postoctoral position on the analyses of dental implant insertion into bone based on microcomputed tomography.

The candidate mission will be to analyze this data set of Sr-μCT scans in order to better
understand the influence of the implant geometry on bone biomechanical behavior during
insertion. Bone morphological characterizations will be held to follow the formation of debris
and the bone volume fraction around the implant. Digital Volume Correlation will also be
applied to follow peri-implant bone strain development during the insertion.


Requested skills:
The post-doctorate candidate must have a strong experience in the manipulation and
processing of volumetric data. Skills in computer languages such as Python or Matlab will be
needed for the further treatment of the data. Some knowledge in biomechanics are preferable
as a digital volume correlation algorithm will be use to investigate bone strain/stress behavior
during implant insertion.

More information:

4 positions at the Institute of Medical and Biological Engineering (IMBE) in Leeds, UK

The Institiute of Medical and Biological Engineering (IMBE) in Leeds, UK, is currently recruiting for 4 positions:

  1. researcher (research fellow requiring a PhD or research assistant requiring a Master) in computational damage biomechanics: https://jobs.leeds.ac.uk/vacancy.aspx?ref=EPSME1154 (for the research assistant role, check your UK working eligibility by contacting InternationalHR@leeds.ac.uk)
  2. post-doctoral research (research fellow requiring a PhD) in knee and hip biomechanical evaluation: https://jobs.leeds.ac.uk/vacancy.aspx?ref=EPSME1155
  3. PhD student in spine biomechanics: https://phd.leeds.ac.uk/project/1826-integrating-morphology-and-mechanics-developing-a-statistical-shape-and-appearance-model-ssam-for-spinal-health-assessment-intervention-planning
  4. PhD student in bone healing: https://phd.leeds.ac.uk/project/1820-computational-biomechanical-modelling-of-external-fixation-of-fractures-to-predict-bone-healing

All details of application processes are available on the respective links, deadlines within the next month.

The multi-disciplinary IMBE is embedded within the School of Mechanical Engineering and the Faculty of Biological Sciences at the University of Leeds. It is a dynamic world-renowned medical engineering research centre which specialises in research and translation of musculoskeletal and cardiovascular medical technologies that promote ’50 active years after 50’.

As a researcher or PhD student within IMBE, there will be opportunities to contribute to wider activities related to medical technologies including public and patient engagement, group training and social events. Groups of researchers working on aligned projects or using similar methods meet regularly to share ideas and best practice, and we encourage collegiate working. We will support your long-term career ambitions through bespoke training and encourage external secondments, laboratory visits or participation at international conferences.

Postdoc position on the Evaluation of Interactions between Motorcyclist, Airbag and Safety Barrier via Numerical Simulations @ Université Gustave Eiffel (Lyon or Marseille, France)

The objective of this joint project (LBA & LBMC) is to integrate the barrier impact into the airbag evaluation processes of the previous REGAM project. This objective thus feeds two strategic issues:

– Quantify the combined effects of wearing an airbag vest and of a safety barrier with or without a motorcyclist screen to reduce the risk of injury during an accident (definition, analysis and choice of injury criteria in a reference case).

– Identify the area of protection (gain/limits) offered by regulatory barriers for different impact situations with the motorcyclist (sensitivity analyses).

To do this, it is a question of establishing a crash numerical modeling combining motorcyclist, motorcycle, airbag and restraint device, based on the previous work on the subject at LBA and LBMC.

More details can be found here:

https://lbmc.univ-gustave-eiffel.fr/fileadmin/redaction/LBMC/Documents/Post-doc/REGAM2_Offre_de_PostDoc_FR_ANG.pdf

Postdoc-Position in Digital Materials Science @Clausthal University of Technology

The Institute for Materials Science and Engineering at Clausthal University of Technology is pleased to announce a postdoctoral position available for three years, with the potential for extension by an additional three years. We welcome applications from individuals who are motivated, enthusiastic, and collaborative, demonstrating a commitment to developing solutions for pressing global challenges. The salary scale for this position is EG 13 TV-L aligning with the German collective labour agreement (indicative gross monthly salary range is €4,188.00 – €6,037.00 depending on experience, family status, etc.). This opportunity is suitable for part-time work and is crafted as a qualification position for postdocs. However, we encourage outstanding candidates, including those without a PhD, to explore the opportunity to pursue a doctorate at Clausthal University of Technology.

The Institute for Materials Science and Engineering at Clausthal University of Technology has a strong application focus in Research and Teaching. The working group Digitalisation in Materials Science and Engineering has a focus on biologic, architectured materials and engineered living materials. The prospective candidate should strengthen this area strategically so that we seek a candidate with a background or interest in biological tissues.

You will find key duties, a description of your profile, what we offer, contact details, and how you can apply under https://tinyurl.com/ycxf74te. We review applications on an ongoing basis and close this advert as soon as we have found a suitable candidate. Please do not hesitate to contact us if you have any questions. We look forward to hearing from you!

Senior postdoctoral researcher in computer methods @Universitat Pompeu Fabra

We are offering a 4-5-year postdoctoral position for our research line Computer methods for modeling based on finite elements and agents in multiscale simulations, within the context of the O-Health project. O-Health is a Consolidator grant from the European Research Council, awarded by the European Commission in the framework of the HORIZON Action (PREUR02822 – HEu – ERC – CoG – O-Health – 101044828) It is directed by Prof. Jérôme Noailly, from the BCN MedTech research unit of the Department of Information and Communication Technologies (DTIC), Pompeu Fabra University (UPF), Barcelona, Spain.

The researcher will be responsible for the development of the multiscale simulation platform of the O-Health project, combining finite element (organ/tissue level) and agent-based (multicellular models) models and solvers.

The researcher will gradually become responsible for the conversion of models based on the physics and biology of the BMMB, into interoperable tools within automated simulation flows, through bottom-up and top-down modeling. Likewise, he will execute and be responsible for the conversion of the models based on the physics and biology of the BMMB, into interoperable tools within automated simulation flows, for the bottom-up and top-down modeling of O-Health. You will define, program and implement workflows using and adapting existing free and open solutions, such as SBML, HDF5 and MUSCLE.
The researcher must check that the project deadlines and deliverables are met, and that the project results can be adequately disseminated through scientific media, congresses and medical journals, as well as periodically report to the PI.

Application deadline: 21/12/2023

More information:

https://euraxess.ec.europa.eu/jobs/113582

2 postdoc positions on computational modeling of Achilles tendon mechanics and/or mechanobiology @Lund University

We are hiring two ambitious and curious post-doctoral researchers in computational modeling of tendons. This position is within the ERC-funded project (Tendon_MechBio) with the scope to elucidate how mechanical loading affects tendon mechanics and tendon regeneration. The modeling will be based on unique experimental data collected within the team. We would like to employ two postdoctoral researchers with the following two aims. 

  1. To develop detailed structural and anatomical computational models of the tendon tissue, in order to understand how mechanical loading influences tendon function, structure and composition. The computational modeling will be based on unique collected experimental data of collagen fiber structure and. The detailed structural models will be key in the project to elucidate the mechanisms guiding the tendon organ and tissue level response to load.
  2. To investigate how mechanical loading influences healing tendon function, structure and composition. The project includes further developing and validating an existing adaptive mechanoregulatory model for tendon repair. This will be based on collected experimental data. The developed computational scheme will be important for the project to elucidate the mechanobiological mechanisms at play.

Applicants can present preferences between aim 1 or 2, or state interest in both options.

The link to the full advertisement and application system is below:

https://lu.varbi.com/en/what:job/jobID:673035/

Application deadline: 7th December

Postdoc position in Experimental Bone-Spine mechanics @University of Sheffield

Are you looking for an exciting PostDoctoral post in Experimental Bone/Spine mechanics?

Join us at Insigneo to work with Dr Enrico Dall’Ara and Prof Damien Lacroix on the recently EU funded METASTRA project!

This highly interdisciplinary post-doctoral position will advance our understanding of the biomechanics of metastatic spine and will create an experimental database for the validation of computational models for assessing metastatic vertebrae before and after treatment.

The position is within Insigneo and is funded as part of Horizon Europe/Innovate UK research project METASTRA (https://www.metastraproject.eu/) that aims to provide a combination of computational models biomechanically validated and demonstrated in relevant clinical environments that will be incorporated in a clinical decision support system.

This part of the project is focused on model validation using state of the art mechanical testing combined with imaging and digital volume correlation.

You will have an excellent PhD in biomechanics (or a related discipline), possess a solid knowledge of bone imaging and experimental biomechanics.

Ensuring the achievement of the project objectives will advance the vision of the Insigneo institute to validate computational models for the musculoskeletal system and produce a transformational impact on healthcare.

The PDRA will also sustain and strengthen collaboration within relevant Insigneo research groups and beyond; and will commit to Insigneo’s mission to produce high quality and impactful cutting-edge research. You will join the group of Dr. Enrico Dall’Ara and Prof Damien Lacroix. Our biomechanics group within the Department has an international and interdisciplinary profile and a strong commitment to clinical and industrial translation with impact in future healthcare. We are active in biomechanics and mechanobiology of the neuromusculoskeletal systems. We have access to a fully equipped human movement analysis laboratory, a tissue testing/mechanobiology laboratory, and to ex vivo and in vivo microCT imaging facilities

Link for Applications

Deadline applications: 6th December 2023

Tentative Start: 1st March 2024

Duration: 3 years


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