Research Assistant (Postdoc) position @ University of Portsmouth in bone regeneration

The School of Engineering is seeking to appoint a research assistant (RA) to contribute to the project “Development of first in vitro protocol for bone formation from osteoregenerative biomaterials”, resulting from a collaborative effort between two research centres at the University of Portsmouth (Zeiss Global Centre: http://www.port.ac.uk/school-of-engineering/zeiss-global-centre/ and Biomaterials and Drug Delivery: http://www.port.ac.uk/school-of-pharmacy-and-biomedical-sciences/research/biomaterials-and-drug-delivery/), one at the University of Southampton (Centre for Human Development, Stem Cells and Regeneration: https://www.southampton.ac.uk/chdscr/about/academics/richard_oreffo.page) and the  commercial partner CellScale (http://cellscale.com/).

The project aims to develop the first in vitro protocol for bone regeneration induced by osteoregenerative biomaterials. This will be achieved through investigation of the relationship between the mechanical characteristics of the employed biomaterials and their ability to produce new bone in a biological environment. The research will provide a better understanding of bone formation when simulated physiological loading is applied, resulting in the development of optimised bone repair materials. In addition, correlative imaging combining confocal microscopy, x-ray microscopy and mechanical testing will ensure in-depth knowledge of the entire transition from cell activity to regenerated bone quality. Overall, the project will provide an initial platform aiming at substituting animal studies in the next future and representing a breakthrough methodological tool for the development of new bone treatments.

The successful candidate should have a strong background in at least two of the following areas: bioengineering, mechanobiology, x-ray/confocal microscopy, mechanical testing and biomaterial formulation. The RA will work in a dynamic environment and benefit from the existing collaborative research between partners.

The post is based at the School of Engineering, University of Portsmouth, with the appointment effective from 2nd January 2018, or as soon as possible after offer. For informal enquiries about the project please contact Dr Gianluca Tozzi at gianluca.tozzi@port.ac.uk or phone +44 (0)23 9284 2514.

Applications should be submitted via the online application system at https://port.engageats.co.uk by the closing date. It is the policy of the University to only accept applications submitted using the University’s online application system.

We welcome applications from all qualified applicants, but applications are particularly encouraged from traditionally under-represented groups in science and engineering. The University of Portsmouth holds an Athena Swan bronze award and is committed to introduce organisational and cultural practices that promote gender equality and create a better working environment for men and women.

For detailed information about the vacancy, please select this link:ZZ004184 – Research Assistant.docx

Postdoctoral Research Associate in Bone and Joint Biomechanics, Sheffield, UK

Job Title:
Postdoctoral Research Associate in Bone and Joint Biomechanics

Description:
A PostDoc position for a highly motivated research scientist to work on a study
funded by the National Centre for Replacement, Refinement and Reduction
of the usage of animals in research (NC3Rs).
The project aims to enhance the assessment of bone and joint properties in
preclinical studies (mouse models), by combining longitudinal high-resolution
imaging, advanced image processing and computational modelling to non-
invasively measure bone strength from the in vivo images. In this project the
post-holder will create and validate computational models for the prediction of
bone strength at each time point in mice scanned with in vivo microCT that allows for high-resolution scans of the mice tibia. Moreover, the post-holder will adapt our protocols to study in details bone changes in the mouse knee to evaluate the effect of OA. Finally, they will be involved in the design and creation of an online service that measures automatically the bone properties in different portions of the tibia and that can be used worldwide by other researchers.
The post will be based at the Insigneo Institute for In silico Medicine and the
Mellanby Centre for Bone Research in Sheffield. Applicants should hold a PhD in
Engineering, Physics or related disciplines (or being close to submit), be familiar
with experimental, imaging, image processing and computational modelling
techniques for assessment of bone properties. Willingness to use the developed
skills towards the 3Rs is essential. The post is full time for 30 months. The post
holder will report to Dr Enrico Dall’Ara.

Contact: e.dallara@sheffield.ac.uk
Start position: 1 st Dec 2017
Duration: 30 months
Closing application: 24 th October 2017

Link Application (use in Keywords: “UOS017290”):
https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_unreg_job_search?sap-client=400&sap-syscmd=nocookie&sap-wd-configId=ZHRRCF_A_UNREG_JOB_SEARCH&sap-
ie=edge&utm_source=university%20website&utm_medium=link&utm_content=jobs&utm_campaign=jobs-link#

Salary: Grade 7; £30,175 to £38,183 per annum

PDRA in Bioreactor Technology, University of Oxford

We are seeking a full-time Postdoctoral Research Assistant to join the Oxford Mechanobiology Group at the Department of Engineering Science, University of Oxford. We have developed and filed a patent on an electromagnetically actuated mechanical bioreactor for studying cultured tissue, and have won impact funding to commercialize this concept with applications in tissue engineering, drug discovery and research instruments. You will be responsible for design and development of miniaturized single and multi-chamber commercial demonstrators of the technology and will need extensive experience of practical project work in electromagnetic actuation, a strong interest in applications in bioreactor technology, and a passion for commercialization.

Click here for further details

Four 12-months PDRA positions at the University of Sheffield

There are 4 exciting PDRA positions at the University of Sheffield starting from September 2017.

The candidates will work in a multidisciplinary environment within two projects funded by the Engineering and Physical Sciences Research Council (EPSRC).

PROJECT1

Job Title: Post Doctoral Research Associate in Bone Biomechanics

Project Title: A 3D realistic FE model of the growing mouse knee joint

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description:

The goal of this project is to generate a 3D realistic finite element (FE) model of the growing mouse knee joint through in vivo and ex vivo micro-Computed Tomography (μCT) imaging.

The post holder will use a combination of contrast enhanced µCT, well-established staining methods, novel elastic registration algorithms, and adaptive biomechanical simulations to explore the relation between mechanics and biology on the process of knee joint growth in mice. In addition, a novel mechanoregulation algorithm for bone and cartilage growth will be explored by means of constrained optimisation techniques.

Supervisors: Dr Mario Giorgi, Dr Enrico Dall’Ara

Contact: m.giorgi@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application: https://jobs.shef.ac.uk/sap/bc/webdy…BC%2fUR%2fuos#

Salary: Grade 7, £30.175 to £38.183 per annum

PROJECT2

Job Title: Postdoctoral Research Associate in Cell and Tissue Multiscale Modelling

Project Title: A Multiscale Bone Remodelling Predictor for Discovering Innovative Therapies to Osteoporosis

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description:

The goal is to expand an in-house agent-based model (ABM) simulating cellular activity during osteogenesis, and to couple this model with a finite element (FE) model of bone tissue.

The post holder will work towards developing dynamic multi-scale bone remodelling units in the tibia responding to biomechanical stimulations under physiological and pathological conditions. A combined agent-based model (ABM) and finite element (FE) framework will be utilised to simulate signalling networks, including that of the parathyroid hormone (PTH), and monitor their influence on cell-cell interaction and emergent behaviour. The models will be integrated into a hypermodelling framework that consists of several sub-models at various scales (cell, tissue, organ, body) so that an overall musculoskeletal model can be generated

Supervisors: Dr Aban Shuaib and Dr Enrico Dall’Ara

Contact: aban.shuaib@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application:

https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MzMwNjJBRkQ4MDQ5MUVENzhERTU0MDBFREQ1NDgyMjkmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#

Salary:

Grade 7 £30,175 to £38,183 per annum

PROJECT3

Job Title: Post-doctoral Research Associate in Multiscale Model Sensitivity Analysis

Project Title: A cost-weighted network analysis to discover clinically feasible and accurate multiscale hypermodels

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description: The aim of the project is to systematically analyse and develop the use of Bayesian inference in a multiscale hypermodel that predicts ageing-related loss of bone strength.

The post-holder will create a cost-weighted network representation of the multiscale model design space applied to osteoporotic loss of bone strength. Surrogate data sources will be identified and linked to the network within Bayesian inference context. Sensitivity analysis and uncertainty propagation analysis of the enriched network will be performed to discover the lowest cost hypermodel.

Supervisors: Dr Pinaki Bhattacharya, Prof Marco Viceconti

Contact: p.bhattacharya@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MzMwNjJBRkQ4MDQ5MUVFNzhERTAyN0JEQzQ2MjUyOEImY2FuZF90eXBlPUVYVA%3D%3D&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=/SAP/PUBLIC/BC/UR/uos#

Salary: (Grade 7) £30,175 to £38,183 per annum

PROJECT4

Job Title: Post Doctoral Research Associate (Biomechanics of OA)

Project Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation

Related Project: OABONE (PI Dr Enrico Dall’Ara; http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P015778/1)

Description: The goal of this project is to use state of the art experimental, imaging and computational techniques to measure how the subchondral bone of the femoral head of osteoarthritic hips deforms under loading.

The post holder will design in situ mechanical testing for testing human femoral heads, use micro computed tomography (microCT) for acquiring the bone microstructure, perform digital volume correlation (DVC) analyses to measure the three dimensional deformation of the bones and generate micro-finite element models to estimate the deformation of the same bones under different loading scenarios.

Supervisors: Dr Enrico Dall’Ara

Contact: e.dallara@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 05/06/17

Link Application: https://goo.gl/N43Ycj

Salary: £30,175 – £38,183 per annum.

Open Position for a Senior Scientist in Biomechanics at TUWien

 

Description: The Institute of Lightweight Design and Structural Biomechanics of TU Wien invites applications for the permanent position of a Senior Scientist in the research group for Biomechanics. One of the main tasks of this post will be acting as a laboratory manager for the Interfacultary Laboratory for Micro- and Nanomechanics of Biological and Biomimetical Materials (www.mmlab.tuwien.ac.at).

Qualifications: We are looking for a scientist with a completed Ph.D. in Mechanical Engineering, Material Science, Biomedical Engineering or Physics who has

  • experience in atomic force microscopy – imaging and mechanical modes (micro- and nanoindentation, tensile tests) as well as data analysis and interpretation of indentation and other mechanical tests,
  • experience in imaging methods such as light microscopy (polarization and fluorescence microscopy, second harmonic generation) and micro computed tomography,
  • experience in teaching Tissue Biomechanics in theory (nonlinear continuum mechanics) and application (experimental biomechanics),
  • additional knowledge in the fields of biomechanics, bone and mechanical testing.
  • Further requested skills: English as native language or proof of at least level B2, CEFR

Further information: For informal discussions please contact Professor Philipp Thurner, pthurner@ilsb.tuwien.ac.at         

How to apply: please send applications to rene.fuchs@tuwien.ac.at no later than February 8th 2017