10th World Congress of Biomechanics 2026 in Vancouver

Postdoctoral Research Associate – Biomechanics (Job Number: 26000814)

  • Job profile: POSTDOCTORAL RESEARCH ASSOCIATE
  • Organisation: DURHAM UNIVERSITY
  • Apply before: 13-07-2026
  • Hours per week: 35 pw
  • Contract duration: 21 months
  • Annual gross salary: £38,784 to £39,906 per annum

Introduction

The Department of Engineering at Durham University is recognised as being one of the very best in the UK. In the Research Excellence Framework (REF) exercise of 2021, the Department had 95% of publications rated as 3*/4*, and all impact case studies graded 3*/4*. The Department demonstrates significant depth of research excellence across a range of disciplines, with activities that are currently concentrated around three Research Challenges (Sustainable Infrastructure, Future Energy Systems and Advanced Materials, Electronics and Communications) and eight Research Nodes which group staff under technical expertise and interest (see https://www.durham.ac.uk/departments/academic/engineering/research/).

We are particularly proud of the collaborative interdisciplinary nature of our research, which also includes strong industrial partnerships. The strategic vision for the Department includes a major growth over the next five years, with a significant enhancement of the research challenge portfolio and a drive to enrich our undergraduate, postgraduate taught and postgraduate research provision.

We are a scholarly community that is open, supportive, collegiate, representative and diverse: our commitment to this is expressed through the work of the Department’s Equality, Diversity, Inclusion and Wellbeing Committee, and our Athena Swan Silver Award.

Job Description

Applications are invited for a Postdoctoral Research Associate (PDRA) position in Bioengineering at Durham University. We are seeking a highly motivated and ambitious researcher with a strong background and experience in biomechanics, finite element modelling (FEM), medical image processing, additive manufacturing (AM). The project will be carried out in close collaboration with Alma Mater Bologna and Great Ormond Street Hospital and is funded by the Academy of Medical Science. This post is fixed term for 21 months from 1/10/26 and will end on 30/6/28. Successful applicants will, ideally, be in post by 1/10/26.

The project, “Biomechanical Design Of Patient Specific Fixation Methods For Mandibular Reconstruction Surgery aims at designing patient specific mandibular fixation methods (miniplates, reconstruction plantes) This project will investigate the possibility of tuning the shape and mechanical properties of the implanted device using additive manufacturing, to target the patient’s specific condition and obtain an optimal long term outcome. FEM coupled with Design of Experiment (DoE) will guide the design of miniplates. Ad-hoc tuning of published mechanobiological models of bone healing will help create a robust model, able to predict long term surgical outcomes in patient specific cases. The results of the validated model will provide insight into the performance of different fixation methods and their suitability for patient-specific mandibular reconstruction. A protocol for the creation of patient specific personalised mini-plates, manufacturable using metal AM, will be designed and experimentally validated.

Key responsibilities:

  • To understand and convey material of a specialist or highly technical nature to the team or group of people through presentations and discussions that leads to the presentation of research papers in conferences and publications.
  • To prepare and deliver presentations on research outputs/activities to audiences which may include research sponsors, academic and non-academic audiences.
  • To publish high quality outputs, including papers for submission to peer reviewed journals and papers for presentation at conferences and workshops under the direction of the Principal Investigator or Grant-holder.
  • To assist with the development of research objectives and proposals.
  • To conduct individual and collaborative research projects under the direction of the Principal Investigator or Grant-holder.
  • To work with the Principal Investigator or Grant-holder and other colleagues in the research group, as appropriate, to identify areas for research, develop new research methods and extend the research portfolio.
  • To deal with problems that may affect the achievement of research objectives and deadlines by discussing with the Principal Investigator or Grant-holder and offering creative or innovative solutions.
  • To liaise with research colleagues and make internal and external contacts to develop knowledge and understanding to form relationships for future research collaboration.
  • To plan and manage own research activity, research resources in collaboration with others and contribute to the planning of research projects.
  • To deliver training in research techniques/approaches to peers, visitors and students as appropriate.
  • To be involved in student supervision, as appropriate, and assist with the assessment of the knowledge of students.
  • To contribute to fostering a collegial and respectful working environment which is inclusive and welcoming and where everyone is treated fairly with dignity and respect.
  • To engage in wider citizenship to support the department and wider discipline.
  • To engage in continuing professional development by participation in the undergraduate or postgraduate teaching programmes or by membership of departmental committees, etc. and by attending relevant training and development courses.   
  • Desire to work in and with a multidisciplinary and multicultural team.

Working at Durham 

  • A competitive salary is only one part of the many fantastic benefits you will receive if you join the University:
  • You’ll receive 30 days annual leave per year in addition to 8 public holidays and 4 customary days per year – a total of 42 days per year. The University closes between Christmas and New Year.
  • We offer a generous pension scheme, and as a new member of staff you will be automatically enrolled into the University Superannuation Scheme (USS).
  • No matter how you travel to work, we have you covered.  We have ample parking across campus, a cycle to work scheme which helps you to buy a bike and discount with local bus and train companies. You can also take advantage of our cost-effective and environmentally friendly Tusker Car Benefit Scheme, allowing you to lease a brand-new electric or hybrid vehicle with savings on tax and National Insurance.
  • We have a genuine commitment to developing our colleagues professionally and personally. There is a comprehensive range of development courses, apprenticeships and access to qualifications and routes to develop your career in the University.  All staff have dedicated annual time to concentrate on their personal development opportunities.
  • We provide wide-ranging health and wellbeing support including discounted membership for our state-of-the-art sport and gym facilities and access to a 24-7 Employee Assistance Programme.
  • Our on-site nursery is rated Outstanding by Ofsted, and you can access holiday camps for children aged 5-16.
  • Our family-friendly policies, including maternity and adoption leave, are among the most generous in the higher education sector (and likely above and beyond many employers).
  • We offer all staff the opportunity to take part in volunteering activities to make a difference in the local community.
  • You can access exclusive discounts via our benefits portal including money off at supermarkets, high street retailers, IT products such as Apple, eating out and days out at various attractions.
  • Various salary sacrifice schemes are also available to help you take advantage of tax savings on benefits.
  •  If you are moving to Durham, you may be eligible for help with removal costs, and we have a dedicated team who can help you with the practicalities such as house hunting and schools.  If you need a visa, we cover most visa costs and offer an interest-free loan scheme to pay for dependant visas.

Contact Information 

  • Department contact for academic-related enquiries: Dr Alessandro Borghialessandro.borghi@durham.ac.uk
  • Contact information for technical difficulties when submitting your application:

If you encounter technical difficulties when using the online application form, we prefer you send enquiries by email. Please send your name along with a brief description of the problem you’re experiencing to e.recruitment@durham.ac.uk 

  • Alternatively, you may call 0191 334 6801 from the UK, or +44 191 334 6801 from outside the UK. This number operates during the hours of 09.00 and 17.00 Monday to Friday, UK time. We will normally respond within one working day (Monday to Friday, excluding UK public holidays).  

Apply here 

https://www.jobs.ac.uk/job/DSC124/postdoctoral-research-associate-biomechanics

or here

https://durham.taleo.net/careersection/du_ext/jobdetail.ftl?job=26000814&lang=en&src=JB10200


Submitting your application 

We prefer to receive applications online. We will update you about your application at various points throughout the selection process, via automated emails from our e-recruitment system. Please check your spam/junk folder periodically to make sure you have not missed any of our updates.

PostDoc Position at Insigneo Institute, University of Sheffield, UK

Want to join us in developing the next generation of orthopaedic implants for bone cancer and trauma patients?

This project aims to characterise the mechanical properties of the bone-implant at different stages of bone ingrowth, so as to inform orthopaedic implant design to achieve improved long-term clinical outcomes for patients. We are looking for someone with a PhD in mechanical engineering or bioengineering, strong expertise in mechanical testing of bone or biomaterials or composites and experience with microCT imaging. Experience with in situ mechanical testing and digital volume correlation will be an advantage. 

This is a 2 year post based at Insigneo Institute, University of Sheffield, UK, that includes a placement at an orthopaedic implant manufacturer, with a salary of around £38 – 41k. The successful candidate will work under the supervision of Dr Vee San Cheong and Prof Enrico Dall’Ara. It’s a great opportunity for someone who wants to work at the intersection of academia, industry and preclinical testing.

https://jobsite.sheffield.ac.uk/job/Sheffield-Research-Associate-in-Experimental-Bone-Biomechanics/1777-en_GB

Two Postdoctoral Positions in Biofabrication at the MERLN Institute

Postdoc Position 1: Computational Biofabrication
Research Focus:
You will contribute to the design and optimization of 3D-printed biomaterial scaffolds using advanced computational approaches. Your role will be central in building mathematical models of scaffold architecture and function, and applying machine learning and evolutionary algorithms to guide the automated generation of novel scaffold designs. This project will include both in silico work (modeling, software development) and experimental validation (fabrication and mechanical/structural characterization of scaffolds).

Postdoc Position 2: Stem Cell Bioengineering
Research Focus:
This position centers around developing and optimizing 3D culture systems for human iPSCs and organoids in combination with engineered scaffolds. You will be responsible for setting up cell culture protocols, performing biological assays, and working closely with materials scientists to integrate cells into biofabricated environments for organoid development and disease modeling.

Two Postdoctoral Positions in Biofabrication at the MERLN Institute – CTR Department Job Details | Maastricht University

Two Postdoctoral Positions in Biofabrication at the MERLN Institute – CTR Department — Maastricht University (UM) — AcademicTransfer

https://www.linkedin.com/jobs/view/4267183154

PostDoc Position at Division Biomechanics of Karl Landsteiner University of Health Sciences, Austria, 30h/week

YOUR TASKS:

  • Independent research activities in the Division of Biomechanics
  • Submission of third-party funding applications
  • Intensifying clinical research and expanding the scientific network
  • Supervision of Bachelor’s, Master’s and PhD students
  • Teaching and assistance with administrative tasks
  • Support for the head of division
  • Participation in scientific conferences

YOUR PROFILE:

  • Completion of an appropriate doctorate (e.g. mechanical engineering, physics, biomedical engineering, etc.) 
  • In-depth knowledge of biomechanical measurement technology (material and/or implant testing) 
  • Adequate track record of publications in scientific journals and conference contributions 
  • Experience with clinical research, medical imaging (CT or MRI), additive manufacturing and/or programming 
  • Good written and spoken German and very good written and spoken English 
  • Structured way of working with a professional attitude

YOUR PERSPECTIVE:

You can expect a challenging job in an internationally visible and highly motivated team -we offer flexible working hours, home office options, a paid lunch break, health care and many other benefits . The Karl Landsteiner University of Health Sciences is dedicated to achieving a balanced mix of male and female academic and non-academic staff. Consequently, applications from female candidates are particularly encouraged. People with disabilities who meet the required qualification criteria are expressly invited to apply and are given special consideration.

Further details: https://www.kl.ac.at/de/wissenschaftlicher-mitarbeiterin-postdoc-fachbereich-biomechanik-30-stunden

APPLICATION:

Applications should include a motivation letter, curriculum vitae and credentials. Please apply online at www.kl.ac.at/karriere with reference to the number “2518” by August 24, 2025 at the latest.

Postdoc position at Solid Mechanics Laboratory of Ecole Polytechnique

Objectives
Myopia is a growing public health threat. By 2050, approx. 4.7 billion people, i.e. more than 50% of the world’s population is expected to suffer from myopia, up from 2.8 billion today. It affects vision quality, increases the risk of eye diseases such as glaucoma or retina delamination, and reduces quality of life. Up to one billion people will be high myopes (superior to -5 Diopters) by 2050, risking blindness.
As a partner of the PREMYOM project, the MΞDISIM team at École Polytechnique and Inria, in close collaboration with clinicians from Rotschild AP-HP Hospital and Essilor company, will develop biomechanical models of the full eye to understand the difference between normal and myopic eyes. We have already started, in an on-going PhD project, to implement models of the different sub-parts of the eyes needed to predict its motion (cornea, sclera, muscle, optic nerve, and so on) on an existing geometry of a normal adult eye. Through the PREMYOM project, we aim now at using patient-specific geometries, from normal and myopic children’s eyes.
More precisely, the project concerns the processing of MRI and OCT images of volunteers of a cohort at Rotschild AP-HP hospital. These volunteers will do high resolution MRI images at rest, and lower resolution images of turned eyes (looking to the left and the right). These images will be completed by OCT images, which give higher resolutions on some regions of the sclera or of the retina. We would like to have a pipeline to extract the different regions of the eyes (muscle, sclera…), and obtain meshes which can be assembled to be used in our model of biomechanical motions. To do so, developments are required to create an automatized pipe-line of feature extractions and meshing, and to couple them with the biomechanical model.
This work will be done in close collaboration with a PhD student and a Post-doc working on the biomechanical model of the eye.

Keywords:
Eye Biomechanics; Image-based Modeling; Finite Element Method; Data assimilation; Machine learning/AI

Candidate profile 
We are looking for a postdoc. The funding is for 2 years, but could be further extended for 3 years. The candidate will have a fair understanding of image processing, and of numerical methods. He/She will be at ease with computational pipelines, and also will have an interest for interacting with clinical and industrial collaborators.

Work environment
The work will take place within the Solid Mechanics Laboratory, on the Ecole Polytechnique campus. It will be supervised by Jean-Marc Allain. It can start as soon as possible.

Contact 
jean-marc.allain@polytechnique.edu

2 PostDoc Positions available at the University of Sheffield

1) Postdoc on Experimental Bone Biomechanics 
-> project: “ChildBone: A novel digital twin to assess bone strength in children”
-> line manager: Prof Enrico Dall’Ara
-> start: September 2025 (or until November 2025)
-> Duration:  34 months
-> Position open to international researchers
-> Application deadline: 30/06/2025
-> link with details and application: https://www.jobs.ac.uk/job/DNI385/research-associate-in-experimental-bone-biomechanics-dallara

2) Postdoc on Computational Bone Biomechanics
-> project: “ChildBone: A novel digital twin to assess bone strength in children”
-> line manager: Dr Xinshan Li
-> start: September 2025 (or until November 2025)
-> Duration:  34 months
-> Position open to international researchers
-> Application deadline: 30/06/2025
-> link with details and application: https://www.jobs.ac.uk/job/DNI384/research-associate-in-computational-bone-biomechanics

PostDoc and PhD position at Insigneo Institute – University of Sheffield

At the Insigneo institute of the University of Sheffield we have two open positions for a PostDoc and a PhD student to contribute to the Virtual Human and Mouse Twins for Osteoporosis (VMHTs-OP) project.

All the details are reported in the links below.

For any information please do not hesitate to contact Prof Enrico Dall’Ara.

1) Postdoc on Computational Bone Biomechanics and Validation (Virtual Mouse Twin)
-> start: September 2025
-> Duration: 3 years
-> Deadline application: March 23, 2025
-> link with details and application:
https://jobsite.sheffield.ac.uk/job/Research-Associate/859-en_GB
Job Nr 859

2) PhD scholarship on Virtual Human Twin for predicting bone adaptation due to pharmacological and biomechanical treatments
-> start: October 2025
-> Duration: 3.5 years
-> Deadline application: March 31, 2025
-> Requirement: UK Home Student (also EU students with settled status, more details here)

-> link with details and application:

https://www.findaphd.com/phds/project/virtual-human-twin-for-predicting-bone-adaptation-due-to-pharmacological-and-biomechanical-treatments/?p155816

 Postdoctoral researcher @  Arts et Métiers 

  • Localisation: ENSAM – Paris Campus 

  • Practical information: 

    • Position available from: 01/01/2025

    • Lab : Institut de Biomécanique Humaine Georges Charpak 

    • Emploi de catégorie: A 

    • Fixed term contract: 12 months, full-time 

    • Remote working: non-teleworking position 

    • Contract type: Post-doc 

    • Salary range (depending on experience and profile): 27k to 34k 

    • ENSAM has an active policy to support and promote equality, diversity and inclusion within its communities. 

    • We encourage applications from a wide range of backgrounds and all our positions are open to people with disabilities. 

  • Candidature : 

Who are we ? 

Since it was founded in 1780, the Ecole Nationale Supérieure Arts et Métiers (YouTubeLink) has been committed to meeting the ever-changing challenges facing industry and society. 

A public scientific, cultural and professional establishment (EPSCP) under the sole supervision of the Ministry of Higher Education and Research, it comprises eight campuses and three institutes spread across the country. 

Its primary mission is to train engineers capable of designing environmentally-friendly products and systems, as well as controlling industrial organisation while keeping risks and costs under control. 

Work environment 

The Institut de Biomécanique Humaine Georges Charpak (IBHGC, Arts et Métiers, Université Sorbonne Paris Nord), which was set up in 1979 and now has over 50 permanent staff, has made the strategic choice to focus on the osteoarticular and musculoskeletal systems, and to explore this system in a variety of ways towards subject-specific modeling of the human body. 

The IBHGC is developing research into the geometric and mechanical modelling of the neuromusculoskeletal system, the experimental in vitro characterisation of this system and the development of quantitative methods for exploring living organisms, with the motto ‘Better understanding for better innovation, at the service of patients and society’. 

The project behind this grant is the result of collaboration with UMRS 1158 ‘Experimental and clinical respiratory neurophysiology’ at Sorbonne University and the R3S department (‘respiration, réanimation, réhabilitation, sommeil’) at the Pitié-Salpêtrière Charles Foix Hospital Group. 

The team is composed by : 

Valérie Attali (MD-PhD), pulmonologist, UMRS1158 Experimental and Clinical Respiratory Neurophysiology, Inserm – Sorbonne University. 

Baptiste Sandoz (PhD, HDR), Associate professor, Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers Sciences et Technologies. 

Damien Bachasson (PhD, HDR), INSERM research fellow, UMRS1158 Experimental and Clinical Respiratory Neurophysiology, Inserm – Sorbonne University. 

Claudio Vergari (PhD, HDR), professor, Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers Sciences et Technologies. 

Laurent Gajny (PhD), Associate professor, Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers Sciences et Technologies. 

Missions 

Working at the Institut de Biomécanique Humaine Georges Charpak and reporting to the Director, you will take part in the ANR BIO-DIAPHRAGME project: “Imaging the diaphragm and biomechanical biomarkers of postural dysfunction in chronic respiratory diseases”. The aim of this research project is to explore the neuro-mechanical coupling between the postural and respiratory systems, focusing on the essential role of the diaphragm. It focuses particularly on patients suffering from chronic obstructive pulmonary disease (COPD), a respiratory disease that progressively alters lung function and posture. 

As part of this interdisciplinary project, your mission will be to develop and evaluate a three-dimensional method for reconstructing the shape of the diaphragm using two X-rays of the face and profile in the standing position, in consultation with the project’s multidisciplinary scientific team. 

Activities 

Your activities will include: 

– Automatic or semi-automatic segmentation of the diaphragm on 3D imaging data (scanner, MRI). 

– Definition and parameterisation of an average 3D model of the diaphragm. 

– Development of a method for automatic analysis of face and profile X-rays: segmentation and annotation of anatomical landmarks. 

– Development of a method for deforming the average model on data obtained from face and profile X-rays. 

– Assessment of the accuracy of the proposed method. 

Aim 

The aim of this post is to provide an operational method for personalised three-dimensional reconstruction of the diaphragm in order to investigate potential biomechanical biomarkers of postural dysfunction in chronic respiratory diseases. 

Desired profile / Skills required 

– Solid programming skills, particularly in image analysis and deep learning are expected. 

– Solid mathematical skills, particularly in geometry and numerical analysis, are also expected. 

– A good level in mechanics, or even biomechanics, would be a plus. 

– Operational know-how 

– Adopt a quality approach to programming 

Personal skills 

– Curious, particularly about health issues, sociable. 

– You also have good listening and adaptation skills. 

Practical information 

Experience: Young researcher (PhD) 

Languages: French/English 

Academic level: Bac + 8 (PhD in computer science/computer vision, biomedical engineering or biomechanics) 

Keywords 

  • Biomedical engineering 
  • Medical imaging 
  • Artificial intelligence 

Advantages 

Joining Ensam means benefiting from a socially committed working environment: 

– Up to 50 days’ leave in your first year, depending on your work pattern 

– Mutual insurance contribution of €15/month 

– 75% contribution to public transport costs 

– Sustainable mobility package 

– Canteen, leisure, sport and culture offers 

Your personal data 

ENSAM processes your personal data in accordance with the RGPD and the French Data Protection Act. 

This processing is carried out for the purposes of managing your application and assessing your skills in relation to the post/internship for which you are applying. 

If you wish to exercise your rights regarding your personal data, you may contact ENSAM’s Data Protection Officer at dpo@ensam.eu 

For full details of the data collected by ENSAM and how your data is processed, you can consult ENSAM’s personal data protection policy HERE

New 4-year PDRA position @ University of Glasgow

deadline 11th July 2024

The University of Glasgow is offering a unique opportunity for a Research Associate to make a leading contribution to the Centre for Future Percutaneous Coronary Intervention Planning.  The vision of the Centre is to develop novel and robust mathematical and statistical methodologies, supported by large clinical data sets, to create computational tools for optimisation of cardiovascular procedures. Based within the James Watt School of Engineering, you will work closely with colleagues from Mathematics & Statistics, Cardiovascular & Metabolic Health and Politecnico di Torino, as well as several leading international clinical centres and medical devices/imaging companies. 

You will work on the development of a range of mathematical models and their numerical solution, covering areas including patient geometry reconstruction, fluid-structure interaction, soft tissue mechanics, growth and remodelling and multiphysics modelling. You should have a PhD, or have equivalent experience, in Applied Mathematics, Physics, Computational Engineering, or a related discipline. You should have theoretical and practical knowledge of building multiphysics mathematical models and numerically solving them. Experience in patient geometry reconstruction from medical imaging, soft tissue mechanics and fluid-structure interaction modelling would be desirable.

You will also be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow.

For more details on the vacancy (147648) and to apply,  please visit the university webpage here: https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=147648

Informal enquiries about the role are welcomed, and should be addressed to Dr Sean McGinty, sean.mcginty@glasgow.ac.uk

Join the VMHTsOP project!

Four Research positions available at Insigneo (University of Sheffield) to join the “Virtual Mouse and Human Twins for optimising Treatments for Osteoporosis (VMHTsOP)” project!
The VMHTsOP project aims at developing the first inter-species Virtual Mouse-Human Twin for predicting bone adaptation over time and optimise biomechanical and/or pharmacological treatments for Osteoporosis. It is a 5 years project that will start in September 2024, led by Prof Enrico Dall’Ara at the University of Sheffield, Division of Clinical Medicine and Insigneo institute. The project has been selected by ERC-consolidator grant and funded by the EPSRC through the EU Guarantee fund.
Don’t miss the opportunity to join the team for this exciting research project!


Current Available Positions:
Research Associate (PostDoc) in “Preclinical musculoskeletal imaging and biomechanics”; 3yrs; start in Sep 2024; closing date applications 4th June 2024
Research Associate (PostDoc) in “Computational musculoskeletal biomechanics”; 3yrs; start in Sep 2024; closing date applications 4th June 2024
Research Technician with expertise in imaging and histology; 3yrs; start in Sep 2024; closing date applications 4th June 2024
PhD student in “A biochemo-mechano multi-scale computational model to predict bone adaptation over space and time”; salary and fees (for UK students) for 3.5yrs; start in Oct 2024; closing date applications 10th June 2024
For any enquiries, please contact Prof Enrico Dall’Ara at e.dallara@sheffield.ac.uk


Summary of the project
Eighty per cent of pharmaceutical interventions fail in patients even after being successful in animal studies. Musculoskeletal (MSK) diseases such as osteoporosis (OP) reduce dramatically the quality of life of millions of affected patients. Mice are the most common animal model to test new treatments. Nevertheless, the extrapolation of their effect onto patients and the identification of which new treatments should be tested in clinical studies is based on simple scaling approaches.
In this project we will develop a new mechanistic computational framework that bridges between mouse and human, informed by in vivo experiments in mice, to discover optimal treatments in patients. We will create two parallel virtual mouse and human twins (VMHTs-OP), based on similar inputs (biomedical images, cell data, gait data) that will predict bone adaptation in function of biomechanical and/or biochemical stimuli. Each virtual twin will be based on advanced multi-scale computational models (multi-body dynamics, finite element and cell-population models) to predict bone adaptation over time and space due to OP and to new biomechanical and pharmacological treatments, identifying in silico the new combined treatments that are likely to be effective in patients, to be tested in future clinical trials.
The models will be going through a comprehensive verification, validation and uncertainties quantification process in order to provide the required credibility for future preclinical applications. The model predictions will be validated against longitudinal mouse experiments and available longitudinal clinical data from known biomechanical or pharmacological interventions. Finally, the validated framework will be used to test in silico several combinations of treatments regimens (overlap, intermitted, drug holidays) and different interventions (microgravity, high strain exercises) that would not be ethically nor economically testable in animal and clinical trials.


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