23rd Congress of the European Society of Biomechanics

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ESB 2017 will take place at the Higher Technical School of Engineering of the University of Seville, from the 2nd to the 5th of July 2017.

Plenary lectures will be delivered by Prof. Ellen Kuhl (Stanford University), Dr. Walter Herzog (University Of Calgary) and Prof. José Manuel García-Aznar (University Of Zaragoza).

Seville is the scent of orange trees under blue skies, the river, shops and streets, the barrios, the outlying areas, la Vega, el Aljarafe, las Marismas, la Campiña, the Southern and Northern Sierras, and Estepa.

Please find out more information about the congress and scientific programme at

https://esbiomech.org/conference/index.php/esb2017/seville/

 

We look forward to welcome you in Seville in 2017!

 

 

PDRA in Bioreactor Technology, University of Oxford

We are seeking a full-time Postdoctoral Research Assistant to join the Oxford Mechanobiology Group at the Department of Engineering Science, University of Oxford. We have developed and filed a patent on an electromagnetically actuated mechanical bioreactor for studying cultured tissue, and have won impact funding to commercialize this concept with applications in tissue engineering, drug discovery and research instruments. You will be responsible for design and development of miniaturized single and multi-chamber commercial demonstrators of the technology and will need extensive experience of practical project work in electromagnetic actuation, a strong interest in applications in bioreactor technology, and a passion for commercialization.

Click here for further details

Four 12-months PDRA positions at the University of Sheffield

There are 4 exciting PDRA positions at the University of Sheffield starting from September 2017.

The candidates will work in a multidisciplinary environment within two projects funded by the Engineering and Physical Sciences Research Council (EPSRC).

PROJECT1

Job Title: Post Doctoral Research Associate in Bone Biomechanics

Project Title: A 3D realistic FE model of the growing mouse knee joint

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description:

The goal of this project is to generate a 3D realistic finite element (FE) model of the growing mouse knee joint through in vivo and ex vivo micro-Computed Tomography (μCT) imaging.

The post holder will use a combination of contrast enhanced µCT, well-established staining methods, novel elastic registration algorithms, and adaptive biomechanical simulations to explore the relation between mechanics and biology on the process of knee joint growth in mice. In addition, a novel mechanoregulation algorithm for bone and cartilage growth will be explored by means of constrained optimisation techniques.

Supervisors: Dr Mario Giorgi, Dr Enrico Dall’Ara

Contact: m.giorgi@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application: https://jobs.shef.ac.uk/sap/bc/webdy…BC%2fUR%2fuos#

Salary: Grade 7, £30.175 to £38.183 per annum

PROJECT2

Job Title: Postdoctoral Research Associate in Cell and Tissue Multiscale Modelling

Project Title: A Multiscale Bone Remodelling Predictor for Discovering Innovative Therapies to Osteoporosis

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description:

The goal is to expand an in-house agent-based model (ABM) simulating cellular activity during osteogenesis, and to couple this model with a finite element (FE) model of bone tissue.

The post holder will work towards developing dynamic multi-scale bone remodelling units in the tibia responding to biomechanical stimulations under physiological and pathological conditions. A combined agent-based model (ABM) and finite element (FE) framework will be utilised to simulate signalling networks, including that of the parathyroid hormone (PTH), and monitor their influence on cell-cell interaction and emergent behaviour. The models will be integrated into a hypermodelling framework that consists of several sub-models at various scales (cell, tissue, organ, body) so that an overall musculoskeletal model can be generated

Supervisors: Dr Aban Shuaib and Dr Enrico Dall’Ara

Contact: aban.shuaib@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application:

https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MzMwNjJBRkQ4MDQ5MUVENzhERTU0MDBFREQ1NDgyMjkmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#

Salary:

Grade 7 £30,175 to £38,183 per annum

PROJECT3

Job Title: Post-doctoral Research Associate in Multiscale Model Sensitivity Analysis

Project Title: A cost-weighted network analysis to discover clinically feasible and accurate multiscale hypermodels

Related Project: MULTISIM (PI: Prof Damien Lacroix; http://multisim-insigneo.org/)

Description: The aim of the project is to systematically analyse and develop the use of Bayesian inference in a multiscale hypermodel that predicts ageing-related loss of bone strength.

The post-holder will create a cost-weighted network representation of the multiscale model design space applied to osteoporotic loss of bone strength. Surrogate data sources will be identified and linked to the network within Bayesian inference context. Sensitivity analysis and uncertainty propagation analysis of the enriched network will be performed to discover the lowest cost hypermodel.

Supervisors: Dr Pinaki Bhattacharya, Prof Marco Viceconti

Contact: p.bhattacharya@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 26 May 2017

Link Application: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MzMwNjJBRkQ4MDQ5MUVFNzhERTAyN0JEQzQ2MjUyOEImY2FuZF90eXBlPUVYVA%3D%3D&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=/SAP/PUBLIC/BC/UR/uos#

Salary: (Grade 7) £30,175 to £38,183 per annum

PROJECT4

Job Title: Post Doctoral Research Associate (Biomechanics of OA)

Project Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation

Related Project: OABONE (PI Dr Enrico Dall’Ara; http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P015778/1)

Description: The goal of this project is to use state of the art experimental, imaging and computational techniques to measure how the subchondral bone of the femoral head of osteoarthritic hips deforms under loading.

The post holder will design in situ mechanical testing for testing human femoral heads, use micro computed tomography (microCT) for acquiring the bone microstructure, perform digital volume correlation (DVC) analyses to measure the three dimensional deformation of the bones and generate micro-finite element models to estimate the deformation of the same bones under different loading scenarios.

Supervisors: Dr Enrico Dall’Ara

Contact: e.dallara@sheffield.ac.uk

Start position: Sep 2017

Duration: 12 months

Closing application: 05/06/17

Link Application: https://goo.gl/N43Ycj

Salary: £30,175 – £38,183 per annum.

Call for PhD students – Curabone EU project

CuraBone is a European Industrial Doctorate, financed by ITN Marie
Sklodowska-Curie Action, looking for 5 highly motivated PhD Students.
CuraBone is a research project that aims to develop a new generation of
patient-specific implants, using advanced modelling techniques such as
Finite Element Analysis, MusculoSkeletal Modeling and bone healing.
The call is open now for all candidates, find all the requirements to
apply here:

PhD Position in cell modelling at UPC, Barcelona Spain

Mechano-Chemical organisation in single cells.
 

We have an open PhD position to study the mechano-chemical organisation of cells from a physical and mathematical point of view. Individually or collectively, cells move due to mechanical and chemical gradients and doing so they self-organise in very specific forms. Understanding the physical laws under mechano-chemical gradients can head to establish new protocols in the control of cell structures. The final goal of the project is to manipulate cells so that the morphology of cell structures can be predicted, e.g. in biological-based prosthesis.

The eventual candidate will work in a newly established and young research group in the field of mechanobiology under the supervision of Dr. Pablo Saez  (http://www-lacan.upc.es/saez/), at the Universitat Politècnica de Catalunya. The lab is part of a broader group with focus on numerical methods in engineering (http://www-lacan.upc.es/). The candidate will also collaborate with Prof. Marino Arroyo  (http://www-lacan.upc.es/arroyo/)  with a broad expertise in numerical methods and cell mechanics. The project is related to a recently granted European Research Project on the mechanobiology of cells at different scales.

The eventual student will work at different scales of the problem. Depending on the candidate’s background the work will be more related to theoretical or numerical developments required to accomplish the project. Therefore, we are looking for students with a wide background of knowledge, with a bachelor degree in mechanical engineering, physics or applied mathematics. The candidate should be a highly dynamic and eager student looking forward expand his/her current knowledge on the field of cell mechanobiology. Biological background is not necessary. The candidate is expected to have a high profiency of the English language, both written and spoken.

Interested candidates should send a motivation letter and the CV along with the academic transcript to pablo.saez@upc.edu. We aim to start the project after the summer of 2017 at the latest. We encourage any interested candidate to send his/her application as soon as possible.

2 PhD theses at the Center for Biomedical and Healthcare Engineering, ARMINES/Mines Saint-Etienne – SAINBIOSE (INSERM-U1059)

 

1) FINITE-ELEMENT MODELING AND PATIENT-SPECIFIC PREDICTION OF ANEURYSM GROWTH AND RUPTURE IN THE ASCENDING THORACIC AORTA 

Keywords: Finite-element method, nonlinear mechanics, mechanobiology, aortic aneurysm, extracellular matrix degeneration, nonlocal mechanics, fluid-structure interactions.

Academic context: This PhD thesis is part of the interdisciplinary Biolochanics – Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine – project (2015-2020) awarded to Stéphane Avril (http://www.mines-stetienne.fr/stephane-avril) under the European Research Council Consolidator Grant scheme (http://erc.europa.eu/consolidator-grants). His group at Mines Saint-Etienne leads major international research projects in the domain of soft tissue biomechanics, focused especially on aortic aneurysm through a longstanding collaboration with the Saint-Etienne University Hospital. The Biolochanics project also relies on collaborations with Yale University (USA).

Scientific context: The growth of aortic aneurysms is associated with several mechano-chemo-biological interactions leading to modifications of the tissue structure including the fragmentation of elastin and changes in the amount and organization of collagen. We have modeled these mechanisms in a constitutive model based on the constrained mixture approach, where each constituent has an elastic constitutive response governed by an anisotropic strain energy function and an inelastic constitutive response governed first by a scalar [1–d]-type damage formulation and second by a permanent deformation gradient related to the growth. The model is implemented as a user material in the Abaqus software.

Project summary: In this thesis, we will first start by performing different sensitivity studies on the numerical model, permitting to calibrate different parameters, including the different degradation rates of collagen and elastin and the related time evolution of stress and strain distribution. Calibration will be performed against experimental data acquired by another person working on the project. After this stage we will apply the model to simulate the growth of ATAA in patients for whom we have reconstructed the aortic geometry for several years (on going longitudinal study at the university hospital of Saint-Etienne). In addition to the geometry, we have also access to hemodynamics through 4D MRI also acquired longitudinally for these patients, and even stiffness of the wall through an inverse method developed by another student working also on the project. All these data will be used to calibrate the finite-element model on a cohort of +20 patients in order to better understand how aneurysms grow and how the damage localizes in the tissue. The final goal will be to simulate numerically the scenario of growth and possible rupture for any patient’s aneurysm, just from the 4D MRI data, thus aiding the surgeon to take important decision such as surgical repair.

Candidate profile: Candidates with strong backgrounds in engineering mechanics, biophysics, biomechanics, and/or applied mathematics are expected. Background in finite elements and nonlinear mechanics will be highly appreciated. Motivation for ground-breaking experimental work and interest in mechanobiology are recommended.

Administrative aspects: Situated in the dynamic Rhône-Alpes region (Lyon – France) in the heart of the European Union, Mines-Saint-Etienne is one of the oldest and most prestigious Grandes Ecoles, and has, since 1816, lived up to its motto “innovante par tradition – inspiring innovation“. Working in a culturally and scientifically most stimulating atmosphere, the successful candidate will earn

internationally competitive salaries. Employment durations is 3 years. The employer is Armines, linked by state-approved agreements to Mines Saint-Etienne. The thesis will start in October 2017.

If you are interested, send a curriculum vitae, a cover letter describing previous research experience and interests, the names and contact information of two references. Please, submit via email with “ERC Biolochanics D3” on the subject line to Prof Stéphane AVRIL, PhD (avril@emse.fr). Deadline for applications: 30th April 2017.

 

 

2) MULTISCALE CHARACTERIZATION OF PROTEOLYTIC REMODELING  AND OF ITS BIOMECHANICAL EFFECTS IN THE AORTIC WALL 

Keywords: Mechanobiology, aortic aneurysm, extracellular matrix degeneration, biomechanical tests, full-field measurements, digital image correlation, OCT, collagenase

Academic context: This PhD thesis is part of the interdisciplinary Biolochanics – Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine – project (2015-2020) awarded to Stéphane Avril (http://www.mines-stetienne.fr/stephane-avril) under the European Research Council Consolidator Grant scheme (http://erc.europa.eu/consolidator-grants). His group at Mines Saint-Etienne leads major international research projects in the domain of soft tissue biomechanics, focused especially on aortic aneurysm through a longstanding collaboration with the Saint-Etienne University Hospital. The Biolochanics project also relies on collaborations with Yale University (USA).

Scientific context: The growth of aortic aneurysms is associated with several morphological abnormalities, particularly in the media. Two abnormalities standout from a mechanical standpoint: the fragmentation of elastin and changes in the amount and organization of collagen. Changes in the organization of these two load-bearing components signal that more than likely significant changes in the mechanical properties are occurring.

Project summary: In this project, we will focus on the contribution of collagen, as the fragmentation of elastin has been implicated in the normal aging process. In aneurysms the normal production and degradation rates of collagen are disturbed leading to enlargement and local weakening of the aortic wall. To investigate this localized weakening of the tissue through degradation of its collagen fibers we will develop a novel biochemically-based method to locally degrade the collagen fibers and characterize its biomechanical effects.

Sample will be cut from aortic tissue and tested in an inflation device. Using a digital image correlation system at the macro scale (developed by a post-doc also working on the project) and an optical coherence tomography (OCT) system at the micro scale (developed by another post-doc), images will be recorded during the inflation. While the pressure is held constant, a fine tipped syringe will be used to apply purified collagenase in buffered saline to a small region of the sample. After the application of collagenase the sample and testing device will be placed in a saline bath for incubation. The selected incubation times are short to ensure that the collagen fibers are only partially degraded. To verify that the enzymatic digestion of collagen occurred we will examine histological images. After the treatment, we will inflate the tissue to failure. We will subject a total of 30 ATAA wall specimens to this protocol.

The stress and strain fields at each pressure stage will be calculated using an inverse method based on the data of the digital image correlation system at the macro scale and of the optical coherence tomography system. The focus will be on determining if any novel local features are identified in the collagenase treated region, particularly at physiologic pressure. We will use the calculated mechanical properties to confirm that the collagenase treatment had the intended effect of weakening the mechanical properties at the application site. The experimental method is fully capable of capturing these local changes in material properties. By comparing the range of rupture stress, we will determine how localized collagen degradation impacts the final rupture stress.

Candidate profile: Candidates with strong backgrounds in engineering mechanics, biophysics, biomechanics, and/or applied mathematics are expected. Background in experimental mechanics

and optical measurement techniques will be appreciated. Motivation for ground-breaking experimental work and interest in mechanobiology are recommended.

Administrative aspects: Situated in the dynamic Rhône-Alpes region (Lyon – France) in the heart of the European Union, Mines-Saint-Etienne is one of the oldest and most prestigious Grandes Ecoles, and has, since 1816, lived up to its motto “innovante par tradition – inspiring innovation“. Working in a culturally and scientifically most stimulating atmosphere, the successful candidate will earn internationally competitive salaries. Employment durations is 3 years. The employer is Armines, linked by state-approved agreements to Mines Saint-Etienne. The thesis will start in October 2017.

If you are interested, send a curriculum vitae, a cover letter describing previous research experience and interests, the names and contact information of two references. Please, submit via email with “ERC Biolochanics D2” on the subject line to Prof Stéphane AVRIL, PhD (avril@emse.fr). Deadline for applications: 30th April 2017.

PhD Student Position in bone, ultrasound, wave propagation, and inverse problem in Marseille

A Ph.D. student position is available in the Laboratory of Mechanics and Acoustics, and the Institute of Movement Sciences in Marseille, France. On-going research topic is as follow; parametric imaging of human children bones using ultrasonic computed tomography, coupled with a therapeutic unit of bone repair stimulation.
The potential candidate will be actively involved in ultrasonic computed tomography research project involving the following numerical and experimental area: ultrasound, wave propagation, inverse problem, ultrasonic imaging, data processing and therapeutic applications.
 All information and details on the subject, and related to the application, the remuneration, benefits, terms of appointment can be found on the dedicated website: http://doc2amu.univ-amu.fr/en/imaging-of-bone-diseases-in-children-using-ultrasonic-computed-tomography
Philippe LASAYGUES (supervisor) and Cécile BARON (co-supervisor)

Open Position for a Senior Scientist in Biomechanics at TUWien

 

Description: The Institute of Lightweight Design and Structural Biomechanics of TU Wien invites applications for the permanent position of a Senior Scientist in the research group for Biomechanics. One of the main tasks of this post will be acting as a laboratory manager for the Interfacultary Laboratory for Micro- and Nanomechanics of Biological and Biomimetical Materials (www.mmlab.tuwien.ac.at).

Qualifications: We are looking for a scientist with a completed Ph.D. in Mechanical Engineering, Material Science, Biomedical Engineering or Physics who has

  • experience in atomic force microscopy – imaging and mechanical modes (micro- and nanoindentation, tensile tests) as well as data analysis and interpretation of indentation and other mechanical tests,
  • experience in imaging methods such as light microscopy (polarization and fluorescence microscopy, second harmonic generation) and micro computed tomography,
  • experience in teaching Tissue Biomechanics in theory (nonlinear continuum mechanics) and application (experimental biomechanics),
  • additional knowledge in the fields of biomechanics, bone and mechanical testing.
  • Further requested skills: English as native language or proof of at least level B2, CEFR

Further information: For informal discussions please contact Professor Philipp Thurner, pthurner@ilsb.tuwien.ac.at         

How to apply: please send applications to rene.fuchs@tuwien.ac.at no later than February 8th 2017

In memoriam: Steve Cowin, a visionary scientist

by Bert van Rietbergen

Steve Cowin passed away October 19 last year. Several generations of ESB members have been raised with his pioneering theories of bone adaptation and bone structure-properties relationships, and it feels like a great loss his contribution to this field now is closed. Rather than writing a full obituary, which can be found elsewhere (http://www.cism.it/about/newsletters/), I wanted to focus this writing on why he was so important for many of the ESB members, and for me in particular.

read more …

Call for Bids hosting ESB 2020

The ESB is inviting proposals for the organization of its annual congress in July 2020. If you are interested in hosting and organizing ESB2020, please read the ESB 2020 Bid rules for details.

Bids should be sent to prof. Harry van Lenthe (harry.vanlenthe@kuleuven.be), Chair of the Meetings Committee. He can also be contacted for further information.

The deadline for submitting your bid for ESB2020 is 31st March 2017.

 

 

Fully funded 3 year studentship PhD Studentship at the University of Southampton

Assessing the impact of hydrodynamic loads on shoulder joint injuries in swimming

Closing Date:   Monday 13 February 2017

Increasing activity and fitness levels across the general population is key to combatting the challenges associated with obesity and an ageing population. Swimming is considered to be beneficial as it offers a non weight-bearing, full-body form of cardiovascular exercise. These benefits might be offset, however, by an increased risk of shoulder injury, a common occurrence within the sport.

This project aims to investigate the mechanisms of shoulder injury through understanding how the hydrodynamic forces acting on a swimmer’s arm are supported by the musculoskeletal structure.

This project is fundamentally interdisciplinary requiring in-depth analysis of both complex fluid dynamics, biomechanics and intricate musculoskeletal systems within the body. The mechanisms of shoulder injury can be investigated through the use of a musculoskeletal model to simulate muscle response and joint loadings in different conditions. However this approach requires accurate stroke kinematics and hydrodynamic forces both of which are extremely challenging to measure in aquatic sports such as swimming.

The study will involve acquiring detailed kinematics of the swimming stroke and the use of advanced Computational Fluid Dynamics to simulate the pressure distribution over the arm. Different optical techniques will be utilised to assess the soft tissue deformations caused by fluid loading and muscle contraction during various tasks. Ultimately this information will be used to predict internal forces in the upper limb during swimming and elucidate on possible mechanisms of shoulder injury.

We are looking for applicants with a strong background in engineering, mathematics or physics, with an interest in sports and biomechanics. A fully funded 3 year studentship is available for UK/EU students, with the stipend at the standard RCUK rate (currently £14500 tax free).

Due to the interdisciplinary nature of this project supervision will be split between the Faculties of Engineering and the Environment and Health Sciences. This project is also supported by both British Swimming and the English Institute of Sport providing a wealth of expertise, support and access to world class biomechanists and coaches. This research will build on the previous experience and success of Southampton’s Performance Sport Engineering Lab and their support of British swimming in both the London and Rio Olympic games.

If you wish to discuss any details of the project informally, please contact Joseph Banks, Fluid Structure Interaction research group, Email: J.Banks@soton.ac.uk, Tel: +44 (0) 2380 59 6625.

Reference:  825117AT
Project Reference:
CMEES-FSI-134

Read the advert and apply online here