The Computational Biomechanics Lab at Michigan State University is looking to fill fixed-term research associate positions. The successful candidate must have a Ph.D. in either mechanical, biomedical, aeronautical, civil engineering, or equivalent field with a strong foundation in programming (C++ and python), computational mechanics, and the finite element method. Special consideration will be given to candidates who are familiar with the open-source finite element library FEniCS, cardiac finite element modeling, medical image processing, and machine learning. The candidate is expected to possess excellent communication and writing skills. In this position, the candidate will work to develop multiscale/multiphysics formulations and code to solve problems related to the cardiovascular system. Additionally, the selected candidate will be expected to help mentor students and publish peer-reviewed journal articles. The successful candidate will enjoy ample training and network!
Outstanding candidates are invited to submit a letter of application detailing their relevant background, providing the names and e-mail addresses of at least three references, a CV to the webpage: careers.msu.edu/cw/en-us/job/509746/research-associatefixed-term
For more information, please contact Dr. Lik Chuan Lee at lclee@egr.msu.edu
Academic Context: The post-doctoral fellow will join the STBio team, from the Centre Ingénierie et Santé (Mines Saint-Etienne) and the SaInBioSE laboratory (INSERM U1059), whose research activities are focused on soft tissue biomechanics. For several years, STBio has been working on the interactions between medical textile devices and the skin, in order to better understand their mechanisms of action and/or to prevent certain complications.
Background: The device under study is a very innovative system developed for the treatment of lymphedema. It consists of a compressive envelope with a structured inner face. Although several clinical investigations have shown its efficiency, its mechanism of action remains poorly understood. It is based on the interface pressure, but also on its spatial and temporal variation, that is exerted on the surface of the skin. The geometrical structure of the inner face determines these pressure variations.
The Karl Landsteiner University of Health Sciences (KL) is part of an academic and research community located at the Campus Krems, and includes a network of comprising teaching hospitals in St. Pölten, Krems, Tulln and Eggenburg. KL is committed to raising its profile in specific areas of biomedicine, biomedical engineering, and biopsychosocial sciences by entering into strategic academic and research partnerships with other institutions.
From Autumn 2022 the KL offers a 2-year research position at the Division „Biomechanics“ (Head: Univ. Prof. Dr. Dieter Pahr) with the option of getting permanent upon adequate performance: Research Assistant/ Lab Manager (Post Doc) (40 h) (f/m/d). The Division Biomechanics is part of Prof. Pahr’s Interuniversity Biomechanics Laboratory, which also includes his research group at the TU Wien. Get some impressions of our recent work from our Youtube Channel!
Your tasks: • Independent experimental research activities in the field of musculoskeletal biomechanics • Publication activities and writing of applications for external funding • Teaching and support in administrative tasks • Supervision of Bachelor, Master and PhD students • Administration and maintenance of the laboratory infrastructure • Support of the laboratory head
Your Profile: • Completion of a suitable doctorate (e.g. mechanical engineering, physics, biomedical engineering, …) • In-depth knowledge in biomechanical testing (material and/or implant testing incl. programming of measurement data analysis) • Appropriate track record of publications in scientific journals as well as conference contributions. • Experience with clinic-related research and imaging techniques (CT or MRI) would be an advantage • Good German and very good English skills, both written and spoken • Process-oriented, accurate, structured way of working with a strong ability to prioritize • Open, resilient and flexible personality with a professional attitude
Your Perspective: You can expect a challenging job in a highly motivated team. KL is committed to an anti-discriminatory employment policy and values equal opportunities and diversity. KL specifically encourages qualified people with different diversity characteristics (gender, age, ethnicity, denomination, sexual orientation, etc.) to apply. The minimum monthly gross salary for this position is 3,670 € (40 hrs) gross per month. Readiness for overpayment exists with appropriate experience and qualification.
Applications should include a motivation letter, curriculum vitae and credentials and should be mailed to Ms. Christina Schwaiger of the Karl Landsteiner University of Health Sciences, Dr.-Karl-Dorrek-Straße 30, 3500 Krems, Austria (bewerbung@kl.ac.at ) referring to jobnumber “2202”. There is the possibility of an ongoing job application until a suitable candidate is found.
The MAtrix / Mechanobiology & Tissue Engineering research group (www.mech.kuleuven.be/mechanobiology) is a bioengineering group that is pioneering the role of cellular forces for microvascular formation and function in health and disease. The group is led by prof. Hans Van Oosterwyck and is one of the few groups worldwide that has established 3D Traction Force Microscopy (TFM) routines and workflows for quantifying cellular force exertion in 3D, and routinely applies them to in vitro models of angiogenesis (endothelial invasion). Together with its research partners, it is currently developing novel in vitro models, compatible with TFM and other methods of cellular force inference, to study the interplay between cellular force exertion, matrix mechanics and fluid flow, and how this interplay contributes to endothelial cell phenotypic changes in the context of endothelial heterogeneity and specific (genetic) diseases that lead to microvascular malformations. The group is looking for a postdoc with strong expertise in the in vitro bioengineering of microvascular networks to strengthen the research team.
The ideal candidate must have: – a PhD in bioengineering or related fields. – strong bioengineering skills relevant for 3D in vitro models of vascular biology, such as micro- or mesofluidics, micro- / biofabrication (e.g. 3D printing), 3D endothelial (co-) culture systems, hydrogel synthesis and functionalization, mechanical design. – experience with optical microscopy, preferably live cell imaging in 3D (confocal microscopy, fluorescence microscopy, genetically-engineered fluorescent reporter systems). – some experience with or exposure to scientific computing (such as finite element modelling) and programming (such as Matlab). – a strong interest in mechanobiology and mechanotransduction, with a desire to learn TFM and related methods. – a strong CV and willingness to apply for a personal postdoc fellowship (together with the PI). – a collaborative attitude; we are looking for a real team player who is willing to help and co-supervise master and PhD students.
You will join a KU Leuven-funded project that is in close collaboration with profs. Liz Jones and Aernout Luttun (Centre for Molecular and Vascular Biology at KU Leuven) and that explores how organ-specific endothelial cell heterogeneity arises from the combination of genetic and mechanical signals. Your role is to explore the role of cellular force exertion in the establishment of organ-specific endothelial phenotypes in combination with extrinsic mechanical signals related to organ-specific matrix mechanics and fluid flow. Apart from using and optimizing recently established monolayer models available in our group, you are expected to develop novel 3D in vitro models of perfused vascular networks compatible with cellular force inference. Apart from the application to the study of endothelial cell heterogeneity, these models must also target the study of microvascular disease, in particular Cerebral Cavernous Malformations (CCMs) which are malformations of the brain microcapillaries. As to the latter, the Van Oosterwyck group has a strong partnership with the research group of dr. Eva Faurobert at the Institute for Advanced Biosciences (University of Grenoble, France), with whom you are expected to closely collaborate as well.
Senior Scientist and head of newly built and equipped human movement lab staff position for a biomechanical engineer with mechanical/mechatronics engineering background and interest in Human Movement Biomechanics and development of assistive devices, available at Vienna University of Technology. The position is initially limited to two years, extension to permanent position possible.
A postdoctoral researcher position is available in the Developmental Biomechanics Group. The research project is focussed on cartilage development and healing, and will be in close collaboration with Prof Pieter Brama from the UCD School of Veterinary Medicine. Experimental (wet lab, e.g., histology) experience (ideally) with musculoskeletal tissues is essential for the position. The funding available is for nine months, but every effort will be made to extend the duration of the position. The start date is asap, and latest July 2022.
Join an exciting interdisciplinary research team of biomedical engineers, prosthetists, physiotherapists, healthcare psychologists, social scientists and software engineers, who are developing a method of designing the bespoke prosthetic ‘socket’ interface between a person and their prosthetic limb, using artificial intelligence (AI) to interpret data from expert clinical designers.
You will work primarily with academics at the University of Southampton (Dr Alex Dickinson, Dr Cheryl Metcalf, Dr Maggie Donovan-Hall and Dr Peter Worsley) on a project led by company partner Radii Devices Ltd (Dr Joshua Steer), with prosthetics service provider Opcare / Ability Matters Ltd.
The Karl Landsteiner University of Health Sciences (KL) is part of an academic and research community located at the Campus Krems, and includes a network of comprising teaching hospitals in St. Pölten, Krems, Tulln and Eggenburg. KL is committed to raising its profile in specific areas of biomedicine, biomedical engineering, and biopsychosocial sciences by entering into strategic academic and research partnerships with other institutions.
From April 2022 the KL offers a 2-year research position at the Division „Biomechanics“ (Head: Univ. Prof. Dr. Dieter Pahr) with the option of getting permanent upon adequate performance: Research Assistant/ Lab Manager (Post Doc) (40 h) (f/m/d). The Division Biomechanics is part of Prof. Pahr’s Interuniversity Biomechanics Laboratory, which also includes his research group at the TU Wien.
Your tasks: • Independent experimental research activities in the field of musculoskeletal biomechanics • Publication activities and writing of applications for external funding • Teaching and support in administrative tasks • Supervision of Bachelor, Master and PhD students • Administration and maintenance of the laboratory infrastructure • Support of the laboratory head
Your Profile: • Completion of a suitable doctorate (e.g. mechanical engineering, physics, biomedical engineering, …) • In-depth knowledge in biomechanical testing (material and/or implant testing incl. programming of measurement data analysis) • Appropriate track record of publications in scientific journals as well as conference contributions. • Experience with clinic-related research and imaging techniques (CT or MRI) would be an advantage • Good German and very good English skills, both written and spoken • Process-oriented, accurate, structured way of working with a strong ability to prioritize • Open, resilient and flexible personality with a professional attitude
Your Perspective: You can expect a challenging job in a highly motivated team. KL is committed to an anti-discriminatory employment policy and values equal opportunities and diversity. KL specifically encourages qualified people with different diversity characteristics (gender, age, ethnicity, denomination, sexual orientation, etc.) to apply. The minimum monthly gross salary for this position is 3,500 € (40 hrs) gross per month. Readiness for overpayment exists with appropriate experience and qualification.
Applications should include a motivation letter, curriculum vitae and credentials and should be mailed by 13th of March 2022 referring to jobnumber “2202” to Ms. Christina Schwaiger of the Karl Landsteiner University of Health Sciences, Dr.-Karl-Dorrek-Straße 30, 3500 Krems, Austria (bewerbung@kl.ac.at ).
The department of Cell Biology-Inspired Tissue Engineering (cBITE) at the MERLN Institute for Technology-inspired Regenerative Medicine at Maastricht University in the Netherlands invites applications for a post-doctoral position. The post-doctoral researcher will perform cutting-edge research in computational modeling methods applied to regenerative medicine and more specifically, to cell-matrix interactions.
Regenerative medicine (RM) holds the promise to cure many of what are now chronic patients, restoring health rather than protracting decline, bettering the lives of millions and at the same time preventing lifelong, expensive care processes: cure instead of care. The scientific community has made large steps in this direction over the past decade, however our understanding of the fundamentals of cell, tissue and organ regeneration and of how to stimulate and guide this with intelligent biomaterials in the human body is still in its infancy. To date, the RM field has focused on studying cell-biomaterial interactions. Materials properties such as elasticity, topography, hydrophobicity, and porosity have all been shown to influence cell fate, and the introduction of high-throughput combinatorial approaches is expediting research and decoupling the properties to further inform the design of biomaterials. However, in order to improve the design of synthetic biomaterials, it is crucial to understand the physiological cell-ECM interactions and how these influence cell behavior. This research project aims to use in silico models to simulate cell-ECM interactions, improve our fundamental understanding thereof and use the obtained knowledge to design improved synthetic matrices.
Project description:
Computational modeling of integrin signaling, cell-ECM interaction to inform the design of synthetic matrices;
Parameter optimization and sensitivity analysis;
Analysis and integration of various in vitro/in vivo data for model calibration.
What we offer:
Computational ecosystem at Maastricht University: Institute for Data Science (IDS), Department of Knowledge Engineering (DKE) and Maastricht Centre for Systems Biology (MacsBio);
Excellent computational and experimental facilities to validate the in silico analyses and predictions in vitro/in vivo;
Interdisciplinary environment within MERLN and the “Materials-driven regeneration (MDR)-consortium”
Project embedding:
The project will be coordinated by the MERLN Institute for Technology-Inspired Regenerative Medicine (http://merln.maastrichtuniversity.nl/) as part of the “Materials-driven regeneration (MDR)-consortium” (see http://www.mdrresearch.nl/ for more information) which brings together an interdisciplinary team of excellent scientists at three leading institutes (ICMS at Eindhoven University of Technology, RMU at Utrecht University and MERLN at Maastricht University). The central goal of MDR’s research program is to investigate, design and use intelligent biomaterials that drive the functional regeneration of living tissues and organs under complex (patho)physiological conditions.
Do you have a strong technical background in experimental joint biomechanics with an interest in spine biomechanics? Would you like to work as part of a multidisciplinary institute to address a clinically-driven challenge?
We are looking for a proactive individual to join our team of researchers at the Institute of Medical and Biological Engineering at the University of Leeds, leading research on longer lasting joint replacements, tissue sparing interventions and biological scaffolds for tissue regeneration.
This role is created part of an EPSRC project aiming to characterise spinal facet joints biomechanics. In the UK, four out of five adults suffer from back pain at some point in their life, some of which require spinal fusion, an invasive intervention designed to stop the motion of the affected spinal area. After fusion however, facet joint degeneration can increase and create new symptoms and long term pain for one in four patients.
This project will develop novel testing methods and tools combining experimental and computational modelling to gain a better understanding of the degenerated facet joint biomechanics and how it changes following fusion. You will join a wider group developing in vitro and in silico preclinical models of musculoskeletal joints.
You will have a strong background in spine biomechanics or in experimental contact mechanics and have a proactive approach to working in an experimental and computational environment. You will join an institute that includes different expertise and substantial experience in supporting early stage researchers in a key phase of their career. We encourage an environment of collaboration, trust and wellbeing, which values difference of ideas and embraces diversity.
More info (job description and how to apply) available HERE Contact: Marlène Mengoni