The postdoctoral position is embedded within the SNSF Sinergia project SLIHI4BONE (Nr. 213520, project start 01.04.2023) focusing on a newly-proposed mechanism explaining the formation of bone in soft tissue, also called heterotopic ossification (doi:10.1016/j.mattod.2018.10.036). According to this mechanism, tissue mineralization may provoke a sustained local ionic homeostatic imbalance (SLIHI), and this local decrease in extracellular calcium may modulate inflammation to trigger bone formation. The general project aim is to assess the validity of this mechanism and to use it for healing large bone defects.

For the multiphoton intravital imaging work package within SLIHI4BONE, we are looking for a motivated Postdoc to join the Institute for Biomechanics at ETH Zurich. The successful candidate will closely interact with the Sinergia collaboration partners at RMS Foundation and ARI Davos:
• Development of intravital imaging protocols for HO and impaired bone healing using time-lapsed micro-computed tomography and multiphoton microscopy
• Extension of intravital imaging technology to include ratiometric imaging for the quantification of bone marrow interstitial pH and calcium concentrations
• Imaging support for in vivo experiments

Further information about the Laboratory for Bone Biomechanics can be found on our website www.bone.ethz.ch. Questions regarding the position should be directed to Prof. Dr. Ralph Müller at ram@ethz.ch (no applications).

A post-doctoral research fellowship is available at the Institute for Biomechanics (ETH Zurich) under the guidance of Prof. Stephen Ferguson, in collaboration with the Schulthess Klinik represented by Prof. Philipp Moroder. The overarching goal is to establish a reference centre for shoulder biomechanics as a collaborative research group connecting the expertise of the partner institutions in clinical science, surgery, human movement analysis, experimental methods and computer simulation to better understand the mechanisms of shoulder injury and degeneration, to explore improved treatments of trauma and pathology and to establish objective measures of clinical outcome.

The post-doctoral research fellowship is available from 01. March 2023, initially funded for a period of three years, with the vision to extend this, contingent on the successful acquisition of additional third-party funding

For further details and application please visit:

https://www.jobs.ethz.ch/job/view/JOPG_ethz_y4jqbFuUYbH5kIYpcu

For more information, please contact Prof. Stephen Ferguson (sferguson@ethz.ch). Note that no applications will be accepted via email.

Closing date 30 september!

UCL is seeking to appoint a Research Fellow to be part of an international, EPSRC funded project to couple synchrotron micro-tomography and SAXS to enable imaging of fibrillar tissue in joints and intervertebral discs. The bioengineering challenge is to determine the correlated 3D deformation and structural changes at the molecular-, fibrillar-, and cell-matrix length-scales under physiological load in intact tissue, and how these alter in ageing, injury, and disease. You will be based at Harwell Campus where Diamond Light Source is located, but will also work with collaborators at QMUL, Manchester, and ESRF (Grenoble). You will also work as part of the CZI funded HiP-CT project scaling these techniques up to large animal and human (ex vivo) joints (see mecheng.ucl.ac.uk/hip-ct/).

Your goal will be to adapt in situ rigs for physiological loading for CT and SAXS imaging and develop experiments and analysis codes to measure strains at the nanoscale using digital volume correlation. A second PDRF will lead the 3D-SAXS development.

The successful candidate will join a dynamic international multidisciplinary group of engineers, biologists, beamline scientists, post-docs and PhD students developing and applying synchrotron X-ray and other techniques to study biological systems. The project is led by Dr H Gupta at QMUL, and Prof. PD Lee leads the UCL component. You will be based at Harwell Campus, but will perform experiments at Diamond, ESRF in Grenoble, and other locations.

The position is available immediate for 2 years.

More information:

https://atsv7.wcn.co.uk/search_engine/jobs.cgi?amNvZGU9MTg4NjUyMCZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJmpvYl9yZWZfY29kZT0xODg2NTIwJnBvc3RpbmdfY29kZT0yMjQ&jcode=1886520&vt_template=965&owner=5041178&ownertype=fair&brand_id=0&job_ref_code=1886520&posting_code=224

Project description
Magnesium-based alloys are some of the most promising materials for future degradable implants. With the help of additive manufacturing, patient-specific implants can be created. However, there is limited knowledge of how to manufacture these types of materials using additive manufacturing. One of the challenges is the high reactivity of magnesium, which leads to evaporation in the chamber and too high levels of intermetallic compounds, resulting in excessive degradation rates. One solution could be amorphous alloys. This project aims to use numerical models to develop such types of materials, and design alloys with appropriate degradation and mechanical properties.

Work duties
The work duties within this interdisciplinary research project include conducting high-quality research, in collaboration with other team members, from the design and manufacturing of the alloys, to characterization of the same, results analysis and finally publication of the work. The work involves, among other things, to plan and carry out different types of studies in numerical modelling of materials, in particular through thermodynamic calculations and the development of numerical nucleation and growth models and their implementation in finite element software. Some verification experiments are also expected to be completed, including through synchrotron and neutron studies. The work also includes analysing the results and, through scientific articles and presentations at international conferences, spread the new knowledge.

The position may include some supervision of students in undergraduate and postgraduate education.

More information:

https://www.uu.se/en/about-uu/join-us/details/?positionId=542805

Application deadline: 25 October 2022!

At the Italian Institute of Technologies (IIT) we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times. You’d be working in a multicultural and multi-disciplinary group, where engineers, computational scientists, and biologists experts collaborate, each with their own expertise, to carry out common research.

A Fellow position for Graduate students or Post-doc on the project: OctoNesys ‘Deciphering the novel principles of the octopus neuromuscular systems control’ is available in the group of Dr. of Letizia Zullo, researcher of the IIT Bioinspired Soft Robotics and Center for Synaptic Neuroscience and Technology (NSYN) of Genoa, Italy.

This research focus on investigating ‘Motor control of the Octopus vulgaris arm’ to gain inspiration for soft robotics using technique of muscle biomechanics, electrophysiology, motion kinematics, neural tracing and imaging. The successful candidate will have a strong background in muscle Biomechanics and/or

Neuroscience. Further experience on motion kinematics and coding (Matlab or Python) is an added value.

This position is full time, with funding for 12 months with a competitive salary and starting from October 15^th. It may be subject to renewal based on founding availability. Graduate students and Post-doc are welcome to apply.

Job Location is the Center for Synaptic Neuroscience and Technology (NSYN) @ IRCCS Ospedale Policlinico San Martino, Genova, Genova, Italy

For further details about this project please contact letizia.zullo@iit.it

To apply please send your cv and motivation letter to letizia.zullo@iit.it

For more information about the research group you can visit https://www.iit.it/it/web/guest/people/-/people/letizia-zullo

The Computational Biomechanics Lab at Michigan State University is looking to fill fixed-term research associate positions. The successful candidate must have a Ph.D. in either mechanical, biomedical, aeronautical, civil engineering, or equivalent field with a strong foundation in programming (C++ and python), computational mechanics, and the finite element method. Special consideration will be given to candidates who are familiar with the open-source finite element library FEniCS, cardiac finite element modeling, medical image processing, and machine learning. The candidate is expected to possess excellent communication and writing skills. In this position, the candidate will work to develop multiscale/multiphysics formulations and code to solve problems related to the cardiovascular system. Additionally, the selected candidate will be expected to help mentor students and publish peer-reviewed journal articles. The successful candidate will enjoy ample training and network!

Outstanding candidates are invited to submit a letter of application detailing their relevant background, providing the names and e-mail addresses of at least three references, a CV to the webpage: careers.msu.edu/cw/en-us/job/509746/research-associatefixed-term

For more information, please contact Dr. Lik Chuan Lee at lclee@egr.msu.edu

Academic Context: The post-doctoral fellow will join the STBio team, from the Centre Ingénierie et
Santé (Mines Saint-Etienne) and the SaInBioSE laboratory (INSERM U1059), whose research activities
are focused on soft tissue biomechanics. For several years, STBio has been working on the interactions
between medical textile devices and the skin, in order to better understand their mechanisms of action
and/or to prevent certain complications.

Background: The device under study is a very innovative system developed for the treatment of
lymphedema. It consists of a compressive envelope with a structured inner face. Although several
clinical investigations have shown its efficiency, its mechanism of action remains poorly understood. It
is based on the interface pressure, but also on its spatial and temporal variation, that is exerted on the
surface of the skin. The geometrical structure of the inner face determines these pressure variations.

Application deadline: 13 july 2022

More information: https://institutminestelecom.recruitee.com/l/en/o/postdoctorante-postdoctorant-modelisation-numerique-de-leffet-mecanique-dun-dispositif-de-compression-sur-la-jambe