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Post-Doctoral Position on Biomechanics of soft fibrous tissue @Gustave Eiffel University and Claude Bernard Lyon 1 University

The Biomechanics and Impact Mechanics Laboratory (LBMC UMR_T9406) is a joint research unit of Gustave Eiffel University and Claude Bernard Lyon 1 University. Around forty permanent staff with complementary skills (solid, structural mechanics, surgeons etc.) work within the LBMC.

Based on societal challenges, the LBMC leads researches, on two research themes:

  • Facilitating travel (automated vehicles, autonomous travel)
  • Maintaining good health  (functional capacities, the repaired body: the implant in its environment).

The LBMC has a strong expertise in mechanical characterization of biological tissues. It is a member of the LabEx PRIMES and IMU, and co-leads the International Associated Laboratory (EVASYM) between Lyon and Montreal.
Statice, founded in 1978, has strong expertise in biomaterials and mechatronics, with applications in health field: medical devices and in-vitro diagnostic tools. Statice develops and produces innovative and customized implants and laboratory equipment in fields requiring advanced technologies such as cardiovascular, neurology, urology, oncology, ophthalmology, etc. Thanks to 30 staff members (PhD, engineers and technicians) and a mechanical and electronic workshop, Statice carries out around one hundred industrial projects per year. At the same time, its SRC label awarded by BPI-FRANCE/OSEO enables it to be involved in medium and long-term upstream research work. Statice is regularly an industrial partner in French and European research projects, to remain at the forefront of tomorrows technologies. Statice is thus recognized in Europe for its innovativeness.

The LBMC and Statice are involved in a new collaborative project supported by the France relance plan, with the aim of characterizing the microstructure and mechanical behavior of the tunica albuginea, and developing a biocompatible substitute produced by electrospinning. This collaboration also involves clinicians from the Urology Department of the Lyon Sud Hospital (Hospices Civils de Lyon). Within the framework of this project, the LBMC and Statice are recruiting a post-doctoral fellow for a period of 18 months.

The future employee tasks will be to:

  • Develop experimental protocols for the characterization of the tunica albuginea, including the quantification of its microstructural arrangement and mechanical behavior, at LBMC,
  • Plan and carry out a series of tests on tunica albuginea samples of cadaver or surgical origin, at the LBMC,
  • Process data with the development of dedicated scripts, at the LBMC and Statice,
  • Contribute to the definition of parameters for the development of prototype synthetic substitutes based on the knowledge acquired on tunica albuginea, at Statice,
  • Contribute to the development of synthetic fibrous tissues by electrospinning, at Statice,
  • Draft and present to the project stakeholders a mid-term and a final report,
  • Write and present scientific papers.

The candidate should have strong skills in experimental characterization and analytical modelling of the mechanical behavior of soft fibrous tissues. He/she will preferably have experience in applying these skills to materials developed using electrospinning or biological materials. Soft skills and good communication skills will be appreciated.

The candidate will be recruited by the Gustave Eiffel University for 18 months. The salary and benefits associated with the position are defined by this institution.

During the whole contract, the candidate will work half of the time at LBMC in Bron (69-France) and the other half at Statice (25-France) according to a schedule to be defined.

To apply, please send simultaneously to Karine BRUYERE (karine-bruyere-garnier@univ-eiffel.fr), Laure-Lise GRAS (laure-lise.gras@univ-lyon1.fr), Melanie OTTENIO (melanie.ottenio@univ-lyon1.fr) and Hugues MONDESERT (h.mondesert@statice.com) and before 24 January 2022, a letter of motivation, a CV and contact information for a recommendation.

Postdoctoral fellowship on predictive simulations to inform personalized rehabilitation programs for knee OA patients @KULeuven

Our team is looking to appoint a postdoctoral fellow on predictive simulations to inform personalized, IMU-based rehabilitation programs for knee OA patients

https://www.kuleuven.be/personeel/jobsite/jobs/proxy/download/60073195

More information:

Postdoc position on Optimized Surgical Techniques and Materials through Multi-Physics Organ Modelling @TU Delft

The candidate will be involved in a multi-disciplinary cardiovascular biomechanics research project at TU Delft, focusing on the development of soft organ multi-physics models of the cardiovascular system. The developed framework aims at providing engineering insights in soft tissue behavior and treatment strategies of congenital heart defects. The long-term goal is to improve patient-specific treatment strategies and to design enhanced surgical materials and equipment. This project will be run in close collaboration with clinical partners at Erasmus MC Hospital in Rotterdam.

More information:

https://www.tudelft.nl/over-tu-delft/werken-bij-tu-delft/vacatures/details/?nPostingId=1955&nPostingTargetId=4673&id=QEZFK026203F3VBQBLO6G68W9&LG=NL&mask=external

Postdoc: In vitro replication of bone pathologies @TU Eindhoven

Job description

Bone is a living tissue that is remodeled throughout life. In healthy human bone homeostasis, bone formation and resorption are in balance. In contrast, many bone diseases are caused by an imbalance in the interaction between bone cells, resulting in a significant change in the 3D morphology and functionality of bone. In an effort to stick to the 3Rs in animal experimentation (i.e. reduction, refinement and replacement), this project aims at implementing bone pathologies (for example osteoporosis). You will be part of the engaging Bioengineering Bone team and be familiarized with the use of our existing 3D in vitro co-culture model which is part of a larger project (NWO Vidi Project MiniBones). Within this project, you are expected to take the current healthy homeostatic state further to simulating bone diseases. This model will allow to simulate not only the interaction of the three main bone cells with each other, it will also take their native 3D environment into account (simulating bone morphology) and aims at providing a conceptual understanding of the bone disease and potential intervention targets.

Job requirements

  • PhD in molecular/cellular biology, biomedical engineering/science or a comparable domain.
  • Ability to conduct high quality academic research, demonstrated for instance by a relevant PhD thesis and/or publication(s).
  • Experience in in vitro tissue models, ideally co-cultures, is preferred.
  • Ability to teach, shown by experience or assistance in teaching and positive evaluations of these teaching efforts.
  • Excellent mastering of the English language, good communication and leadership skills. Note that there is no Dutch language requirement.
  • You can effectively communicate scientific ideas, excel at teamwork and have a capability for independent thinking.
  • Be a team player and able to work in a dynamic, interdisciplinary context.

More information: https://jobs.tue.nl/en/vacancy/postdoc-in-vitro-replication-of-bone-pathologies-895212.html#top

Postdoc position in stochastic finite-element modelling @Sheffield University

Does a highly interdisciplinary research role within a world top 100 university excite you? Are you keen to make a world-leading impact by advancing the state-of-the-art in computational modelling? Then this post-doctoral research opportunity at the INSIGNEO Institute for in silico Medicine could be for you.

This research associate position is funded by the UK EPSRC as part of the project titled “A stochastic finite element modelling framework to predict effect sizes on bone mechanics in preclinical studies” (PI: Dr Pinaki Bhattacharya). The aim of this project is to develop efficient numerical methods to accurately predict the stochasticity in mouse bone mechanics.

More information:

https://www.jobs.ac.uk/job/CJE447/research-associate-in-stochastic-finite-element-modelling

Postdoc Position in vascular Biomechanics @University of Pavia

Within the frame of NECESSARY project, we are looking for a candidate with a strong background in computational mechanics willing to join our multidisciplinary team for a two year period (1+1).


Activities and position:
• Carry out medical image processing, solid mechanics simulations of endovascular implants, and CFD/FSI analyses for
coronary/vascular biomechanics
• Full time position at the University of Pavia, with regular visits to San Donato Hospital (clinical partners of the project)


Profile:
• PhD in biomedical engineering/mechanical engineering, or applied mathematics
• Research experience and interest in the field of vascular biomechanics
• Proved experience in team working and project management
• C(++)/Python/MATLAB knowledge
• Knowledge of simulation software (e g Abaqus, ANSYS, open
source)

Send your CV with a cover letter to Prof. M. Conti (michele.conti@unipv.it)

Happy Feet – Multi-scale models of the ankle-foot complex – postdoc position @KULeuven

Come join our team at KU Leuven! We are looking for a highly motivated postdoc candidate to work on our exciting in-vivo and in-vitro modelling of the ankle-foot complex using a combination of imaging-based MSK and FE modelling.

Full posting and application can be found at https://www.kuleuven.be/personeel/jobsite/jobs/60035284?hl=en&lang=en

and here:

MSCA postdoctoral fellowship on mechano-immunotherapy @University of Zaragoza

A research proposal in the field of Mechano-Immunotherapy is offered under the Marie Sklodowska Curie Postdoctoral Fellowship programme at University of Zaragoza – Spain, within the Laboratory of Mechanical and Biological Engineering:

https://m2be.unizar.es

The topic for the proposed research is “Effectivity of cell-based immunotherapies under different mechanical microenvironments”.

WHO ARE WE?

The M2BE research group mainly focuses its activity on the development of new methodologies and technologies in the field of cell mechanobiology.

In this context, we work on the combination of different methodologies (computer simulation models, in-vitro experimentation and clinical validation), which result in the following lines of research: Computational design of prostheses and implants for personalized treatments, tissue engineering and mechanobiology, mechano-immunotherapy, mechanobiology of tumor growht and metastasis.

HOW TO APPLY?

Candidates will be pre-selected based on their expression of interest, CV and motivation.

They must have a demonstrated track in Cell-Based Immunotherapies with expertise engineering CAR-Ts, NKs and TILs.

There are 3 main requirements of eligibility:

Applicants must have a PhD and no more than 8 years of full time research experience*

Applicants can be of any nationality but must not have lived or worked in Spain for more than 12 months during the 3 years up to the closing date of the call 15 September 2021 (mobility rule)

The applicants must choose the University of Zaragoza as their Host Institution

Motivated postdoctoral candidates are encouraged to submit their application to m2be@unizar.es by June 15, 2021.

Selection process

Applicants should check that they fulfil all the eligibility criteria and then send an expression of interest consisting of: CV and letter of interest (max. 2 pages)

Expressions of interest must be submitted by email (m2be@unizar.es) by June 15, 2021. The title of the e-mail must be “MSCA application – MECHANO-IMMUNOTHERAPY– your name and surname“.

Proposals will be preselected on the basis of internal evaluation.

* The researcher must be, at the date of the PF call deadline (15.9.2021) in possession of a doctoral degree. At the call deadline, supported researchers must have a maximum of 8 years full-time equivalent experience in research, measured from the date that the researcher was in a possession of a doctoral degree. Years of experience outside research and career breaks (e.g. due to parental leave), will not be taken into account.

Postdoc position at TUEindhoven: Computational and experimental remodeling of heart valves

This vacancy is posted as part of RegMedXB, which stands for “Regenerative Medicine Crossing Borders”. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. The RegMedXB Cardiac Moonshot program aims at developing innovative strategies to regenerate the tissues of the heart, including the myocardium, heart valves and blood vessels.

The current project concentrates on preserving and regenerating heart valve function under non-physiological loading conditions. For this you will investigate the structural and biological remodeling of heart valves using a combination of experimental and computational research.
The experimental research will focus on establishing an ex vivo platform to investigate the remodeling and functionality of heart valves under various hemodynamic conditions.
The computational part focuses on simulating valve remodeling, with the aim of understanding and predicting experimental outcomes, and extrapolating findings to relevant in vivo situations.

If you are fascinated by the engineering aspects of regenerative medicine and eager to develop innovate models and strategies that will advance cardiovascular regeneration, we invite you to join us in this challenge. You will collaborate intensively with our partners in the RegMed-XB Cardiac Moonshot consortium, in particular with the University Medical Centers in Leiden and Utrecht on ex vivo tissue remodeling, and with other TU/e groups on computational modeling and tissue engineering.

More information can be found here: https://jobs.tue.nl/en/vacancy/postdoc-%E2%80%93-computational-and-experimental-remodeling-of-heart-valves-876785.html

PostDoc in Computational Biomechanics @ TU-Wien

The Institute of Lightweight Design and Structural Biomechanics at TU Wien, Computational Biomechanics Group of Prof Dieter Pahr, is offering a full-time position (40 hours/week) for a post-doc university assistant for two years. The estimated starting date is June 1, 2021.

Tasks:

  • Conducting outstanding research work at an international level in the field of bone biomechanics
  • Supervision of Master and PhDs students
  • Writing grant proposals and acquiring third-party funds
  • Contributing to bachelor and master level teaching
  • Participation in teaching activities and administrative tasks of the institute

Your profile:

  • PhD in the field of mechanical engineering, civil engineering, biomedical engineering or a related discipline with a specialization in biomechanics is a prerequisiteA highly motivated, resilient person with very good communication skills
  • The successful candidate will work in the field of computational bone biomechanics
  • Previous experience in bone biomechanics, image processing, finite element modelling, material modelling, computer programming (C++ and Python) are required
  • A very good command of English language skills as well as an appropriate publication record are also required
  • Desirable are experiences with lab experiments, German language skills, and project proposals writing
  • Interest in solving scientific problems in an independent and goal-oriented manner
  • The willingness to contribute to interdisciplinary and international scientific projects
  • Very good scientific communication and scientific writing skills

We offer:

  • A creative environment in one of the most livable cities in the world.
  • A young, highly motivated, and international team of researchers.
  • An internationally established working group.
  • A well-equipped work environment (soft- and hardware, biomechanics lab).
  • Continuing personal and professional education.
  • Opportunities for presenting research results at leading international conferences.

TU Wien is committed to increase female employment in leading scientific positions. Female candidates are explicitly encouraged to apply. Preference will be given when equally qualified. People with special needs are equally encouraged to apply. In case of any questions, please contact the confidant for disabled persons at the university (contact: gerhard.neustaetter@tuwien.ac.at)

Entry level salary as a postdoctoral researcher is covered by level B1 of the Austrian Collective Agreement for university staff, and receives a minimum of currently EUR 3.889,50 month gross, 14 times/year. Relevant working experiences may increase the monthly income.

We look forward to receiving your application until April 8th, 2021.

For inquires on the technical description please contact Prof. Dr. Dieter Pahr ( dieter.pahr@tuwien.ac.at ).

Application Documents: The application should include a motivation letter, a scientific CV, diploma certificates, list of publications, and a copy of the PhD thesis, all in electronic form. Applications are only accepted via our online system https://jobs.tuwien.ac.at/Job/146061.


Corporate members of the ESB:

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