ESBiomech24 Congress in Edinburgh

PhD Positions in Failure Criterion for Implanted Bone Screws @KLKREMS

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The Karl Landsteiner University of Health Sciences (KL) is part of an academic and research community located at the Campus Krems, and includes a network of comprising teaching hospitals in St. Pölten, Krems and Tulln. The university offers degree programs in Human Medicine, Psychotherapy, Counselling Sciences and Psychology and are tailored to the requirements of the Bologna model, opening the door to new, cutting-edge health professions. KL is committed to raising its profile in specific areas of biomedicine, biomedical engineering, and biopsychosocial sciences by entering into strategic academic and research partnerships with other institutions.

Starting at November 2018, the department of anatomy and biomechanics (division of biomechanics, Prof. Pahr, Dr. Reisinger) offers a research position, which is limited to the duration of three years:

Research Assistant m/f (Pre Doc, 30 h)

Your responsibilities:

  • Participation in the funded research project “A morphology based failure criterion for implanted bone screws”
  • In more detail: using of micro CT imaging, biomechanical testing, continuum mechanics, and 3d- printing
  • Programming of evaluation- and analysis scripts
  • Assistance in teaching in the fields of mathematics, physics, informatics and biomedical engineering
  • Engagement in other research projects

Your profile:

  • Degree in civil or mechanical engineering, biomedical engineering, technical physics, or similar fields
  • Basic knowledge in programming, biomechanics, imaging (CT), experimental material
  • characterization
  • Good English skills
  • The willingness to support teaching, experience is of advantage
  • Self-responsible and reliable working approach
  • Interest on scientific working and writing a dissertation
  • Friendly and team oriented personality

Your perspective:

  • You can expect a challenging job in an internationally recognized and highly motivated team
  • Achieve the academic degree of a PhD (Dr. techn.), issued from the TU Vienna.

The Karl Landsteiner University of Health Sciences is dedicated to achieving a balanced mix of male and female academic and non-academic staff. Consequently, applications from female candidates are particularly welcome.

The minimum gross salary for this position is € 2.112,40 (30 h).

Applications should include a motivation letter, curriculum vitae, and credentials and should be mailed by 17.10.2018 to Ms. Christina Schwaiger of the Karl Landsteiner University of Health Sciences, Dr.-Karl- Dorrek-Straße 30, 3500 Krems, Austria (bewerbung@kl.ac.at).

Webinar: THR Planning with Corin OPS and Simpleware Software

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Title: From Virtual Pre-Operative Planning to Surgical Reality – THR Planning with Corin OPS and Simpleware Software

Date: Wednesday, October 03, 2018

Time: 11:30 AM Eastern Daylight Time

Duration: 1 hour

Summary

This webinar will explore the Corin OPS™ Total Hip Replacement (THR) system through a patient’s journey. This involves performing pre-operative patient-specific analysis to improve surgical outcomes. We will demonstrate how medical imaging is used to create a personalized plan for the surgical procedure, including patient-specific 3D printed guides. In addition, tools are provided for post-operative assessment.

We will show how Synopsys’ Simpleware™ software has been used to streamline the OPS process, capitalizing on flexible scripting capabilities to enable the development of custom tools and a bespoke robust workflow, reducing the time per surgical case required and increasing consistency and traceability.

In this webinar you will:

  • Recognize the benefits of virtual pre-surgical planning
  • Understand Corin’s OPS™ system for transforming medical images into personalized surgical plans
  • See the value of integrating Simpleware software to automate pre-surgical planning workflows

See http://bit.ly/2OMr7Nc for more details

Applications Engineer – Simpleware Software, Exeter, UK

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Applications Engineer

18295BR

GREAT BRITAIN – Exeter

Job Description and Requirements

Overall purpose of job

Simpleware software is currently looking for a motivated applicant to join the technical support team. You should be passionate about working with image processing and 3D modelling software, and with providing technical knowledge and sales support. You will also be responsible for generating papers and promotional material which will require you to work very closely with customers and partners.

We offer a competitive salary for this position.

The closing date for this job posting is the 10th of September, 2018

Primarily, this will involve

  • Providing high quality and reliable technical support for our clients
  • Organising software demonstrations, workshops, and training
  • Visiting potential clients, and attending conferences and exhibitions
  • Generating proposals, papers, reports, press releases, software documentation, tutorials, etc.
  • Establishing new, and maintaining existing, long-term relationships with customers, partners and the media

Knowledge, experience, skills, and competencies

  • Qualified at least to first degree level in an Engineering related subject – preferably a first or 2:1
  • Experience using CAD, FEA (e.g. Abaqus, Ansys, Comsol, etc.) or CFD (e.g. Fluent, OpenFOAM, etc.) codes
  • Good knowledge of either image processing, biomechanical or materials modelling
  • Excellent presentation, communication and interpersonal skills
  • Strong personal organisation, with good project management skills and ability to work to deadlines
  • Strong project management ability, personal organisation and customer focus
  • Self-motivation and ability to work on own initiative whilst being a team player
  • Knowledge of scripting languages (e.g. Python) and web technologies (HTML, CSS, Java Script, PHP and MySQL) would be useful/an advantage

further details and apply online

PhD Project – Cardiff / Synopsys Inc Exeter, England, United Kingdom

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Job description

Synopsys NE Ltd (https://www.synopsys.com/simpleware.html) invites applications for an Early Stage Researcher position (Doctoral Candidate) as part of the Rapid Biomechanics and Simulation for Personalized Clinical Design (RAINBOW) MCSA European Training Network. RAINBOW is funded under the European Union’s Horizon 2020 research and innovation program.

The post holder will be employed on a fixed term (36-month contract) and be principally based at the Synopsys-Simpleware offices in Exeter UK but will also be enrolled as a full time graduate student at Cardiff University (http://www.cardiff.ac.uk/) undertaking research towards a PhD degree award. The candidate will be expected to spend periods of time in Cardiff as well as with other partners in the consortium.

The post holder will develop numerical methods to simulate the deformations of soft-tissues in the context of computer-aided surgery. In particular, he/she will contribute to bridging the gap between advanced 3D imaging techniques and physics-based computer simulations in order to improve current capabilities in the area of computer-aided diagnostic and surgical planning. A thorough knowledge of software development is essential.

This is a full time (37.5 hours per week) position on a fixed term basis for a fixed-term of 36 months.

See https://www.linkedin.com/jobs/view/755835607/ for further details

PhD Project – Luxembourg / Synopsys Inc Exeter, England, United Kingdom

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Job description

Synopsys NE Ltd (https://www.synopsys.com/simpleware.html) invites applications for an Early Stage Researcher position (Doctoral Candidate) as part of the Rapid Biomechanics and Simulation for Personalized Clinical Design (RAINBOW) MCSA European Training Network. RAINBOW is funded under the European Union’s Horizon 2020 research and innovation program.

The post holder will be employed on a fixed term (36-month contract) and be principally based at the Synopsys-Simpleware offices in Exeter UK but will also be enrolled as a full time graduate student at the University of Luxembourg (https://wwwen.uni.lu/) undertaking research towards a PhD degree award. The candidate will be expected to spend periods of time in Luxembourg as well as with other partners in the consortium.

The post holder will develop numerical methods to simulate the deformations of soft-tissues in the context of computer-aided surgery. In particular, he/she will contribute to bridging the gap between advanced 3D imaging techniques and physics-based computer simulations in order to improve current capabilities in the area of computer-aided diagnostic and surgical planning. A thorough knowledge of software development is essential.

This is a full time (37.5 hours per week) position on a fixed term basis for a fixed-term of 36 months.
See https://www.linkedin.com/jobs/view/755834914/ for further details.

PhD: mechanics of a synthetic elastic protein and effects on arterial function @ Lyon

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Doctoral thesis at the Center for Biomedical and Healthcare Engineering

Mines Saint-Etienne – SAINBIOSE (INSERM-U1059) – Université de Lyon (France)

 

Mechanical characterization and modeling of a synthetic elastic protein and its effects on the arterial function

 

Keywords: biomechanics, multiscale models, homogenization, elastin, mechanical characterization, tissue engineering.

 

Scientific context: Elastin is the main elasticity provider for several soft tissues (such as dermis, arteries, pulmonary alveoli) in its fibrous form and a signaling molecule in cell/extracellular matrix interaction. Elastin-rich elastic fibers allow the large artery walls to transform the pulsatile blood flow ejected by the heart into a continuous blood flow in the peripheral arteries (Windkessel effect). Dysfunctions are highly correlated with diseases such as artery stenosis, aneurysm, hypertension or cardiac hypertrophy, which have strong repercussions on arterial biomechanics and can threaten the vessel integrity.

Setting aside surgery, there is currently no treatment for preventing, blocking or treating any loss of elasticity. It therefore appears, from a biomechanical point of view, that the introduction of an entity that provides elasticity within the arterial wall would be the most trivial action to stop arterial stiffening, but remains currently limited due to chemo-biological issues. The Arterylastic project, to which the thesis is linked, proposes to unlock this technological barrier using an original synthetic elastic protein (SEP) recently developed with a synthetic backbone devoted to skin engineering.

 

Academic context: As previously mentioned, the thesis takes place in a larger project named Arterylastic, funded by ANR, combining pluridisciplinary approaches of three laboratories in France: LBTI – the Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (UMR5305 CNRS/UCBL1 Lyon), HP2 –Hypoxie Physiopathologie Cardiovasculaire et Respiratoire (INSERM U1042 – University Grenoble Alpes) and Sainbiose (within the Center for Biomedical and Healthcare Engineering CISSAINBIOSE/INSERM U1059 – Mines Saint-Etienne). The PhD student will work at CIS, which also conducts major international research projects in the field of soft tissue biomechanics, in particular aortic aneurysms. He will collaborate with other researchers involved in ERC projects (https://www.mines-stetienne.fr/en/author/avril/, https://www.emse.fr/~badel/).

 

Objectives: The objective is to restore (or at least improve) arterial function and mechanical properties under conditions of elastic fibers injury. The objective will be reached if the SEP is correctly integrated into elastic fibers and if the SEP restores arterial wall elasticity and/or physiological parameters in relevant animal models. In this thesis, we will evaluate the mechanical behavior of the cross-linked SEP and of arterial samples from treated mouse models and a numerical model will be developed from experimental data to better predict treatment parameters.

The main tasks will be:

  1. Experimental tests will be carried out for characterizing the macroscopic mechanical properties of the SEP and of arteries treated with the SEP. The cross-linked SEP will be characterized using tensile tests with a customized device. Mechanical parameters of treated arteries will be assessed by measuring pressure-diameter curves from mouse arteries tested in a customized tension-inflation test.
  2. A multiscale numerical model of the mechanical behavior of arteries will be elaborated, taking into account their microstructural composition and morphology (bilayer, specific contributions of elastin, collagen, smooth muscle cells, possible proteoglycans) and including the effects of possible grafting of the SEP to the arterial wall. The model will be tested for arteries with competent elastic fibers, for arteries with damaged elastin and induced-tissue remodelling, and for arteries treated with the SEP.
  3. The experimental results obtained at task 1 will be used to evaluate and calibrate the prediction ability of the numerical model developed in task 2. Sensitivity analysis permitting to find the optimal treatment conditions with the SEP for different types of therapeutic targets will be addressed.

 

Candidate profile: Candidates with strong skills in mechanics (modeling and experimental) and biomechanics are expected. Motivation and interest in bioengineering applications is recommended.

 

How to apply:Send CV, cover letter and letters of recommendation to claire.morin@emse.fr and avril@emse.fr.

PhD in Platelet Biomechanics @ University Medicine Greifswald

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Position

One PhD position is available at University Medicine Greifswald, Greifswald, Germany within the newly funded Deutsche Forschungsgemeinschaft (DFG) Transregional Collaborative Research Center (SFB / TR 240) “Platelets – Molecular, Cellular and Systemic Functions under Physiological and Pathological Conditions”. The project will start in July 2018 and runs until June 2022. Salary is based on TV-L (E-13, 65%).

Project Description

The selected candidate will investigate the ‘Role of the Platelet Cytoskeleton in Platelet Biomechanics’. Briefly, circulating platelets are essential players in haemostasis and thrombosis. Interestingly, mutations in several genes of cytoskeletal-regulatory proteins have been identified to cause inherited thrombocytopenia. However, how defects in cytoskeletal-regulatory proteins affect biomechanical properties of platelets and how translates into increased risk of bleeding are only poorly explored. The PhD candidate will have access to relevant disease models and innovative biophysical tools to quantitatively describe the underlying ‘biophysical’ and ‘biomechanical’ aspects of platelet cytoskeleton-associated defects in platelet function.Selected candidate will have access to cutting-edge scientific infrastructure, highly innovative projects in an excellent scientific environment and opportunities to collaborate with national and international research groups.

Our profile

We are an interdisciplinary team consisting of bioengineers, biophysicists and platelet biologists. The PhD candidate will be based in the Department of Transfusion Medicine, University Medicine Greifswald (supervised by Dr. Raghavendra Palankar) and will closely collaborate with Dr. Oliver Otto (Group Leader-Biomechanics, ZI HIKE, Greifswald) and Dr. Markus Bender (Group Leader-Megakaryocyte and Platelet, Department of Experimental Biomedicine, University Würzburg).

Your profile

Candidates with a Diploma/Master degree in Natural Sciences (Biology/Bio-Technology/Chemistry/Physics) career interest in biophysics are encouraged to apply. Ideally, the candidate has high interest in cellular biomechanics. The project requires previous experience in at least one or more of the following skills: force spectroscopy, microfluidics, quantitative imaging, MATLAB /Mathematica/COMSOL Multiphysics, data analysis skills and handling of microscopes. Scientific communication skills in English are necessary.Disabled applicants will be preferentially considered in case of equivalent qualification. The University Medicine Greifswald seeks to increase the number of women and therefore explicitly encourages them to apply.

Application

Interested candidates should send their application until August 15th, 2018 including curriculum vitae (max. two pages), one page description of past research experience and contact details of two references to palankarr@uni-greifswald.de preferably as a signle PDF file in an email attachment.

UPF accepts applications for Junior Leader postdocs

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In its quality as a Maria de Maeztu Center of Excellent the DTIC at University Pompeu Fabra accepts applications in the The postdoctoral fellowships programme, Junior Leader “la Caixa”

 

Especially, the Biomechanics and Mechanobiology Lab of the Barcelona Centre for New Medical Technologies (BCN MedTech) is looking for applicants in any of the following fields:

  • Computational multiscale biomechanics
  • Soft/hard tissue multiphysics
  • Multibody dynamics and human movement analysis
  • Computational systems biology of musculoskeletal, arterial and pulmonar tissues
  • Image analyses and machine learning applied to computational biomechanics and systems biology

Should you be interested to apply, please contact Dr Jérôme Noailly (jerome.noailly@upf.edu)

The postdoctoral fellowships programme, Junior Leader “la Caixa” aims to hire excellent researchers—of any nationality—who wish to continue their research career in Spanish or Portuguese territory. . Sponsored by Obra Social ”la Caixa”, the objectives of this programme are to foster high-quality, innovative research in Spain and to support the best scientific talents by providing them with an attractive, competitive environment in which to conduct excellent research.

The Junior Leader programme is divided into two different frames:

  • Incoming: 22 postdoctoral fellowships for researchers of all nationalities. They will be offered a three-year employment contract to conduct a research project at accredited centres with the Severo Ochoa or María de Maeztu distinction of excellence, Institutos de Investigación Sanitaria Carlos IIII and units evaluated as excellent and exceptional by the Fundação para a Ciência e Tecnologia of Portugal. For Spanish institutions, candidates must have resided in Spain less than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal less than 12 months in the last three years.
  • Retaining: 11 postdoctoral fellowships for researchers of all nationalities to carry out research at any university or research centre in Spain or Portugal. For Spanish institutions, candidates must have resided in Spain more than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal more than 12 months in the last three years.

By means of a complementary training programme, these fellowships are intended to consolidate research skills and to foster an independent scientific career as an option for the future.

Deadline September 26th 2018!

Apply now

 

 

Postdoc position: COMPUTER MODELING OF THE MECHANO-BIOLOGICAL REGULATION OF ANGIOGENESIS @ CHARITE

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Computer modeling of the mechano-biological regulation of angiogenesis

 

A post-doctoral fellowship is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin). This position is funded through a collaboration grant (Research Unit 2165: Regeneration in Aged Individuals) from the German Research Foundation (DFG) to study the mechanical regulation of sprouting angiogenesis during bone regeneration. Research goals are being addressed through a combination of in vitro/in vivo experimentation and computer modeling.

The successful candidate will have a strong background in one or more of the following areas: mechanics, bioinformatics, computational biology and/or computational mechanics. Strong programming and computer modelling skills are required. The position is available for two years with an option to renew provided that adequate progress is made and that the project funding is continued.

The work will be conducted in an interdisciplinary research environment composed of engineers, biologists and clinicians. As a postdoc you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international scientists.

 

Interested candidates should submit their curriculum vitae and two references by August 31, 2018. Applications should be sent to: Prof. Sara Checa (sara.checa@charite.de)

PhD Positions in 3D Bioprinting and Multiscale Modeling of Personalized Bone Organoids @ETHZ

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The Laboratory for Bone Biomechanics headed by Prof. Ralph Müller at the Department of Health Sciences & Technology, Institute for Biomechanics at ETH Zurich is offering
PhD Positions in 3D Bioprinting and Multiscale Modeling of Personalized Bone Organoids
The aim of the research is to develop a human-based 3D bioprinted bone organoid model that mimics tissue remodeling of healthy or osteogenesis imperfecta (OI) individuals and to investigate OI pathomechanisms. One of the major challenges in OI patients today is to diminish the risk of bone fractures. OI is a genetically heterogeneous inherited disorder of bone matrix formation and remodeling, characterized by pain and recurrent fractures, impairment in ambulation, short stature and multiple skeletal complications. Currently, there are no pharmacological interventions available that effectively treat or prevent fractures or limb deformities. Animal and in vitro experimental models used as test beds for new pharmacological/implants interventions do not allow a deep understanding of pathomechanisms behind the disease. To facilitate a better approximation to the in vivo situation in humans, in this project, we aim at the development of personalized 3D-bioprinted bone organoids for genetically distinct forms of osteogenesis imperfecta to investigate i) the pathophysiology and the biomechanics of OI bone and ii) the bone fracture repair process in order to find novel treatments for personalized bone repair in OI patients. In addition, computational models can assist in the elucidation of the effects of pharmacological treatments and studying the biological complexity quantitatively while reducing simultaneously time and costs compared to animal studies. The positions will be based at ETH Zurich in close collaboration with the University’s Children Hospital in Zurich. The overall goal of the project is to improve the clinical care for patients affected by osteogenesis imperfecta and provide individualized, evidence-based therapy, rehabilitation, and surgical interventions.
For this highly interdisciplinary project, we currently offer two PhD positions enrolled in the graduate program at ETH Zurich. The successful candidate for the experimental part of the project will hold a master’s degree in Biology, Health Sciences and Technology, Life Sciences or similar field. The candidate should have a strong background in cell and molecular biology. Knowledge in 3D-bioprinting and tissue engineering is advantageous but not required. The successful candidate for the computational part of the project will hold a master’s degree in Computational Sciences, Interdisciplinary Sciences, Electrical, Chemical or Mechanical Engineering or similar field and has preferentially a background in imaging, image processing and computational modeling. Knowledge in computer programing (preferentially Python) is advantageous but not required. It is essential that candidates are willing and motivated to work at the interface between biological, engineering and clinical research. Additionally, excellent communication skills in English (oral and written) are required. Knowledge of German is advantageous for the clinical interactions but not absolutely required.

We are looking forward to receiving your online application including a motivation letter, CV, full university transcripts and names and contact details of two references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.For further information please contact Dr. Marina Rubert at marina.rubert@hest.ethz.ch (no application documents) or visit our group website www.bone.ethz.ch.

Apply now

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