Closing date 30 september!
UCL is seeking to appoint a Research Fellow to be part of an international, EPSRC funded project to couple synchrotron micro-tomography and SAXS to enable imaging of fibrillar tissue in joints and intervertebral discs. The bioengineering challenge is to determine the correlated 3D deformation and structural changes at the molecular-, fibrillar-, and cell-matrix length-scales under physiological load in intact tissue, and how these alter in ageing, injury, and disease. You will be based at Harwell Campus where Diamond Light Source is located, but will also work with collaborators at QMUL, Manchester, and ESRF (Grenoble). You will also work as part of the CZI funded HiP-CT project scaling these techniques up to large animal and human (ex vivo) joints (see mecheng.ucl.ac.uk/hip-ct/).
Your goal will be to adapt in situ rigs for physiological loading for CT and SAXS imaging and develop experiments and analysis codes to measure strains at the nanoscale using digital volume correlation. A second PDRF will lead the 3D-SAXS development.
The successful candidate will join a dynamic international multidisciplinary group of engineers, biologists, beamline scientists, post-docs and PhD students developing and applying synchrotron X-ray and other techniques to study biological systems. The project is led by Dr H Gupta at QMUL, and Prof. PD Lee leads the UCL component. You will be based at Harwell Campus, but will perform experiments at Diamond, ESRF in Grenoble, and other locations.
The position is available immediate for 2 years.