Institutes: Queensland University of Technology (QUT, Australia), and University of Paris Est Creteil (UPEC, France) — Multiscale modeling and simulation lab (MSME UMR 8208 CNRS).
Résumé: We seek to better understand how cortical bone is affected by osteoporosis and drug treatments. The successful PhD candidate will develop state-of-the-art computational models of bone remodeling to predict changes in cortical porosity and bone matrix properties due to osteoporosis and other treatment regimens. The in-silico results will be validated by experimental data provided by Prof David Cooper (USASK). Project areas include:
• Development of continuous, i.e. based on partial differential equations, models of bone remodeling to investigate the behaviour of basic multicellular units (BMUs) in cortical bone;
• Development of discrete, i.e. cellular automata based, models of BMU behaviour in cortical bone;
• Development of multiscale models of bone remodeling and adaptation that are able to predict changes in cortical porosity and bone tissue mineral density distribution.
Closing date: Applications will be accepted until the scholarship is awarded, but applications will be assessed starting June 25th, 2023.
More information (salary, essential and desirable criteria, etc.):