Healthy cartilage functions in an environment with low oxygen levels (normoxia) and changes in oxygen sensing have been associated with osteoarthritis. This project aims to clarify hypoxia signaling in cartilage with varying mechanical loading and oxygen pressures. Ultimately our research aims to identify potential therapeutic molecules that can prevent cartilage degeneration and osteoarthritis.
The position is supervised by Dr. Mikko Finnilä, who has recently formed his own research group that studies musculoskeletal biomaterials. His group is focused on imaging and biomechanics of tissues and biomaterials to identify more effective materials for musculoskeletal repair. Group has active collaboration internationally as well as with local industry. The most important collaborators for this project are Prof. Marcy Zenobi-Wong (ETH Zurich) and Prof. Peppi Karppinen (Faculty of Biochemistry and Molecular Medicine).