Objectives
Myopia is a growing public health threat. By 2050, approx. 4.7 billion people, i.e. more than 50% of the world’s population is expected to suffer from myopia, up from 2.8 billion today. It affects vision quality, increases the risk of eye diseases such as glaucoma or retina delamination, and reduces quality of life. Up to one billion people will be high myopes (superior to -5 Diopters) by 2050, risking blindness.
As a partner of the PREMYOM project, the MΞDISIM team at École Polytechnique and Inria, in close collaboration with clinicians from Rotschild AP-HP Hospital and Essilor company, will develop biomechanical models of the full eye to understand the difference between normal and myopic eyes. We have already started, in an on-going PhD project, to implement models of the different sub-parts of the eyes needed to predict its motion (cornea, sclera, muscle, optic nerve, and so on) on an existing geometry of a normal adult eye. Through the PREMYOM project, we aim now at using patient-specific geometries, from normal and myopic children’s eyes.
More precisely, the project concerns the processing of MRI and OCT images of volunteers of a cohort at Rotschild AP-HP hospital. These volunteers will do high resolution MRI images at rest, and lower resolution images of turned eyes (looking to the left and the right). These images will be completed by OCT images, which give higher resolutions on some regions of the sclera or of the retina. We would like to have a pipeline to extract the different regions of the eyes (muscle, sclera…), and obtain meshes which can be assembled to be used in our model of biomechanical motions. To do so, developments are required to create an automatized pipe-line of feature extractions and meshing, and to couple them with the biomechanical model.
This work will be done in close collaboration with a PhD student and a Post-doc working on the biomechanical model of the eye.Keywords:
Eye Biomechanics; Image-based Modeling; Finite Element Method; Data assimilation; Machine learning/AICandidate profile
We are looking for a postdoc. The funding is for 2 years, but could be further extended for 3 years. The candidate will have a fair understanding of image processing, and of numerical methods. He/She will be at ease with computational pipelines, and also will have an interest for interacting with clinical and industrial collaborators.Work environment
The work will take place within the Solid Mechanics Laboratory, on the Ecole Polytechnique campus. It will be supervised by Jean-Marc Allain. It can start as soon as possible.
