Applications are invited from suitably qualified candidates for multiple full-time, fully-funded positions that will investigate the mechanobiology of tumour growth and therapy resistance. These positions are funded by a European Research Council Starting Grant and will be under the supervision of Dr Eoin McEvoy, Assistant Professor in Biomedical Engineering. The researcher will join Dr McEvoy’s group, which brings together expertise in biophysical modelling, active cell biomechanics, and in-vitro tumour models. The group’s overall focus is to develop advanced computational and experimental models that provide a mechanistic understanding of cell and tissue remodelling in cancer and disease, motivating novel mechano-therapeutics and treatment strategies. For further information, see www.mechanomodel.ie.
Project Description: Personalised medicine presents an exciting frontier in healthcare that tailors disease mitigation and intervention to an individual patient. This project will develop integrated experimental and computational models for the prediction of cancer patient outcomes, leveraging the biophysical forces that underpin cell behaviour. PhD research topics will bridge subcellular remodelling, single cell mechanobiology, and macroscale tumour evolution to provide a new and fundamental understanding of tumour growth and therapy resistance in breast cancer. As part of the PhD programme (project dependent), you will receive training in computational and experimental cell mechanics, patient-derived tumour organoid generation, microfluidic cell culture, advanced microscopy, agent-based modelling, and/or advanced finite element analysis.
Application Deadline: Applications will be reviewed periodically until January 31st, 2024.