Nucleus pulposus regulatory network model of non-degenerate intervertebral disc by Sofia Tseranidou, Universitat Pompeu Fabra.
This image a knowledge-based regulatory network where proteins are represented by nodes and their inhibition and/or activation effect by edges. Only the most important soluble proteins, that take part in the Intervertebral disc regulation are included. Light blue colour represents the anabolic components while orange colour the catabolic components. Green lines indicate activation of a node regarding a specific stimuli and red lines indicate inhibition. There are 31 proteins with 146 interactions among them. This static snapshot can be converted into dynamical by using a method which proposes a fuzzy logic semi-quantitative interpolation of boolean solutions for RN.
