PhD/Master student positions

 

2 PhD theses at the Center for Biomedical and Healthcare Engineering, ARMINES/Mines Saint-Etienne – SAINBIOSE (INSERM-U1059)

1) FINITE-ELEMENT MODELING AND PATIENT-SPECIFIC PREDICTION OF ANEURYSM GROWTH AND RUPTURE IN THE ASCENDING THORACIC AORTA 

Keywords: Finite-element method, nonlinear mechanics, mechanobiology, aortic aneurysm, extracellular matrix degeneration, nonlocal mechanics, fluid-structure interactions.

Academic context: This PhD thesis is part of the interdisciplinary Biolochanics – Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine – project (2015-2020) awarded to Stéphane Avril (http://www.mines-stetienne.fr/stephane-avril) under the European Research Council Consolidator Grant scheme (http://erc.europa.eu/consolidator-grants). His group at Mines Saint-Etienne leads major international research projects in the domain of soft tissue biomechanics, focused especially on aortic aneurysm through a longstanding collaboration with the Saint-Etienne University Hospital. The Biolochanics project also relies on collaborations with Yale University (USA).

Scientific context: The growth of aortic aneurysms is associated with several mechano-chemo-biological interactions leading to modifications of the tissue structure including the fragmentation of elastin and changes in the amount and organization of collagen. We have modeled these mechanisms in a constitutive model based on the constrained mixture approach, where each constituent has an elastic constitutive response governed by an anisotropic strain energy function and an inelastic constitutive response governed first by a scalar [1–d]-type damage formulation and second by a permanent deformation gradient related to the growth. The model is implemented as a user material in the Abaqus software.

Project summary: In this thesis, we will first start by performing different sensitivity studies on the numerical model, permitting to calibrate different parameters, including the different degradation rates of collagen and elastin and the related time evolution of stress and strain distribution. Calibration will be performed against experimental data acquired by another person working on the project. After this stage we will apply the model to simulate the growth of ATAA in patients for whom we have reconstructed the aortic geometry for several years (on going longitudinal study at the university hospital of Saint-Etienne). In addition to the geometry, we have also access to hemodynamics through 4D MRI also acquired longitudinally for these patients, and even stiffness of the wall through an inverse method developed by another student working also on the project. All these data will be used to calibrate the finite-element model on a cohort of +20 patients in order to better understand how aneurysms grow and how the damage localizes in the tissue. The final goal will be to simulate numerically the scenario of growth and possible rupture for any patient’s aneurysm, just from the 4D MRI data, thus aiding the surgeon to take important decision such as surgical repair.

Candidate profile: Candidates with strong backgrounds in engineering mechanics, biophysics, biomechanics, and/or applied mathematics are expected. Background in finite elements and nonlinear mechanics will be highly appreciated. Motivation for ground-breaking experimental work and interest in mechanobiology are recommended.

Administrative aspects: Situated in the dynamic Rhône-Alpes region (Lyon – France) in the heart of the European Union, Mines-Saint-Etienne is one of the oldest and most prestigious Grandes Ecoles, and has, since 1816, lived up to its motto “innovante par tradition – inspiring innovation“. Working in a culturally and scientifically most stimulating atmosphere, the successful candidate will earn

internationally competitive salaries. Employment durations is 3 years. The employer is Armines, linked by state-approved agreements to Mines Saint-Etienne. The thesis will start in October 2017.

If you are interested, send a curriculum vitae, a cover letter describing previous research experience and interests, the names and contact information of two references. Please, submit via email with “ERC Biolochanics D3” on the subject line to Prof Stéphane AVRIL, PhD (avril@emse.fr). Deadline for applications: 30th April 2017.

2) MULTISCALE CHARACTERIZATION OF PROTEOLYTIC REMODELING  AND OF ITS BIOMECHANICAL EFFECTS IN THE AORTIC WALL 

Keywords: Mechanobiology, aortic aneurysm, extracellular matrix degeneration, biomechanical tests, full-field measurements, digital image correlation, OCT, collagenase

Academic context: This PhD thesis is part of the interdisciplinary Biolochanics – Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine – project (2015-2020) awarded to Stéphane Avril (http://www.mines-stetienne.fr/stephane-avril) under the European Research Council Consolidator Grant scheme (http://erc.europa.eu/consolidator-grants). His group at Mines Saint-Etienne leads major international research projects in the domain of soft tissue biomechanics, focused especially on aortic aneurysm through a longstanding collaboration with the Saint-Etienne University Hospital. The Biolochanics project also relies on collaborations with Yale University (USA).

Scientific context: The growth of aortic aneurysms is associated with several morphological abnormalities, particularly in the media. Two abnormalities standout from a mechanical standpoint: the fragmentation of elastin and changes in the amount and organization of collagen. Changes in the organization of these two load-bearing components signal that more than likely significant changes in the mechanical properties are occurring.

Project summary: In this project, we will focus on the contribution of collagen, as the fragmentation of elastin has been implicated in the normal aging process. In aneurysms the normal production and degradation rates of collagen are disturbed leading to enlargement and local weakening of the aortic wall. To investigate this localized weakening of the tissue through degradation of its collagen fibers we will develop a novel biochemically-based method to locally degrade the collagen fibers and characterize its biomechanical effects.

Sample will be cut from aortic tissue and tested in an inflation device. Using a digital image correlation system at the macro scale (developed by a post-doc also working on the project) and an optical coherence tomography (OCT) system at the micro scale (developed by another post-doc), images will be recorded during the inflation. While the pressure is held constant, a fine tipped syringe will be used to apply purified collagenase in buffered saline to a small region of the sample. After the application of collagenase the sample and testing device will be placed in a saline bath for incubation. The selected incubation times are short to ensure that the collagen fibers are only partially degraded. To verify that the enzymatic digestion of collagen occurred we will examine histological images. After the treatment, we will inflate the tissue to failure. We will subject a total of 30 ATAA wall specimens to this protocol.

The stress and strain fields at each pressure stage will be calculated using an inverse method based on the data of the digital image correlation system at the macro scale and of the optical coherence tomography system. The focus will be on determining if any novel local features are identified in the collagenase treated region, particularly at physiologic pressure. We will use the calculated mechanical properties to confirm that the collagenase treatment had the intended effect of weakening the mechanical properties at the application site. The experimental method is fully capable of capturing these local changes in material properties. By comparing the range of rupture stress, we will determine how localized collagen degradation impacts the final rupture stress.

Candidate profile: Candidates with strong backgrounds in engineering mechanics, biophysics, biomechanics, and/or applied mathematics are expected. Background in experimental mechanics

and optical measurement techniques will be appreciated. Motivation for ground-breaking experimental work and interest in mechanobiology are recommended.

Administrative aspects: Situated in the dynamic Rhône-Alpes region (Lyon – France) in the heart of the European Union, Mines-Saint-Etienne is one of the oldest and most prestigious Grandes Ecoles, and has, since 1816, lived up to its motto “innovante par tradition – inspiring innovation“. Working in a culturally and scientifically most stimulating atmosphere, the successful candidate will earn internationally competitive salaries. Employment durations is 3 years. The employer is Armines, linked by state-approved agreements to Mines Saint-Etienne. The thesis will start in October 2017.

If you are interested, send a curriculum vitae, a cover letter describing previous research experience and interests, the names and contact information of two references. Please, submit via email with “ERC Biolochanics D2” on the subject line to Prof Stéphane AVRIL, PhD (avril@emse.fr). Deadline for applications: 30th April 2017.

 


 

PhD Student Position in bone, ultrasound, wave propagation, and inverse problem in Marseille

A Ph.D. student position is available in the Laboratory of Mechanics and Acoustics, and the Institute of Movement Sciences in Marseille, France. On-going research topic is as follow; parametric imaging of human children bones using ultrasonic computed tomography, coupled with a therapeutic unit of bone repair stimulation.
The potential candidate will be actively involved in ultrasonic computed tomography research project involving the following numerical and experimental area: ultrasound, wave propagation, inverse problem, ultrasonic imaging, data processing and therapeutic applications.
 All information and details on the subject, and related to the application, the remuneration, benefits, terms of appointment can be found on the dedicated website: http://doc2amu.univ-amu.fr/en/imaging-of-bone-diseases-in-children-using-ultrasonic-computed-tomography
Philippe LASAYGUES (supervisor) and Cécile BARON (co-supervisor)

 

Fully funded 3 year studentship PhD Studentship at the University of Southampton

Assessing the impact of hydrodynamic loads on shoulder joint injuries in swimming

Closing Date:   Monday 13 February 2017

Increasing activity and fitness levels across the general population is key to combatting the challenges associated with obesity and an ageing population. Swimming is considered to be beneficial as it offers a non weight-bearing, full-body form of cardiovascular exercise. These benefits might be offset, however, by an increased risk of shoulder injury, a common occurrence within the sport.

This project aims to investigate the mechanisms of shoulder injury through understanding how the hydrodynamic forces acting on a swimmer’s arm are supported by the musculoskeletal structure.

This project is fundamentally interdisciplinary requiring in-depth analysis of both complex fluid dynamics, biomechanics and intricate musculoskeletal systems within the body. The mechanisms of shoulder injury can be investigated through the use of a musculoskeletal model to simulate muscle response and joint loadings in different conditions. However this approach requires accurate stroke kinematics and hydrodynamic forces both of which are extremely challenging to measure in aquatic sports such as swimming.

The study will involve acquiring detailed kinematics of the swimming stroke and the use of advanced Computational Fluid Dynamics to simulate the pressure distribution over the arm. Different optical techniques will be utilised to assess the soft tissue deformations caused by fluid loading and muscle contraction during various tasks. Ultimately this information will be used to predict internal forces in the upper limb during swimming and elucidate on possible mechanisms of shoulder injury.

We are looking for applicants with a strong background in engineering, mathematics or physics, with an interest in sports and biomechanics. A fully funded 3 year studentship is available for UK/EU students, with the stipend at the standard RCUK rate (currently £14500 tax free).

Due to the interdisciplinary nature of this project supervision will be split between the Faculties of Engineering and the Environment and Health Sciences. This project is also supported by both British Swimming and the English Institute of Sport providing a wealth of expertise, support and access to world class biomechanists and coaches. This research will build on the previous experience and success of Southampton’s Performance Sport Engineering Lab and their support of British swimming in both the London and Rio Olympic games.

If you wish to discuss any details of the project informally, please contact Joseph Banks, Fluid Structure Interaction research group, Email: J.Banks@soton.ac.uk, Tel: +44 (0) 2380 59 6625.

Reference:  825117AT
Project Reference:
 CMEES-FSI-134

Read the advert and apply online here


 

Effect of low calories diet on the musculoskeletal health in UM-HET3 mice

Doctoral Academy & University Prize Scholarships

Project Details: Age-delaying interventions are currently tested on animal models such as UM-HET3 mice. Among them, calorie restriction (CR) was found to increase the life-spam in mice models and has the potential of delay age-related pathologies. However, the effect of CR on the musculoskeletal health is still debated and becomes fundamental when studying its effect on musculoskeletal pathologies such as osteoarthritis (OA) and osteoporosis (OP).
The hypothesis of this study is that CR improves musculoskeletal health in old UM-HEY3 mice. In this project the student will characterise the properties of the knee joints and o whole tibiae of UM-HET3 mice in order to study the effect of CR on the properties of cartilage and bone and its relationship with gender and age. Tissues from female and male mice at three different ages (8, 12 and 22 months) have been already collected by our collaborators and will be analysed in Sheffield. The student will be taught how to perform state of the art assessments of OA and OP by combining micro-computed tomography (microCT) imaging, image processing and computational modelling. MicroCT allows us to acquire 3-dimensional high-resolution images of the whole bone and joint and to analyse in details their morphological and densitometric properties. Furthermore, microCT-based finite element (FE) models developed in Dall’Ara’s group are engineering methods that can provide a non-invasive assessment of bone mechanical properties from the acquired images. The assessment of degree of OA, bone morphometric parameters, distribution of bone mineral density within the tibia and bone strength will be provide a unique database for the characterisation of the effect of CR on bone and cartilage.

Entry Requirements

Candidates must have a first or upper second class honors degree or significant research experience. Strong imaging and/or computational background is required; experience with microCT image processing will be advantageous.

Funding

The Faculty of Medicine, Dentistry & Health Doctoral Academy Scholarships cover Home/EU fee and RCUK rate stipend for three years. Overseas students may apply but will need to fund the difference between the Home and Overseas fee from another source.

How to apply

Please apply through our online postgraduate application system including the Scholarship Application section where you need to tick the ‘University Scholarships’ box. The form will ask you to summarise your research proposal in less than 800 words. If you are unsure about what to put in this section, please contact your prospective supervisor. Please name your supervisor and select their department Oncology and Metabolism through the online form.

Deadline: 5pm 1st February 2017

Supervisors: Dr Enrico Dall’Ara, Department of Oncology and Metabolism and INSIGNEO institute for in silico medicine and Dr Ilaria Bellantuono, Department of Oncology and Metabolism.

Enquiries:
Interested candidates should in the first instance contact Dr Dall’Ara  e.dallara@sheffield.ac.uk


 

Job opening for Ph.D. student at the Institute of Orthopaedic Research and Biomechanics, Ulm University

The joint biomechanics group of the Institute of Orthopaedic Research and Biomechanics at the Ulm University Medical Centre invites applications for a
PhD student position (3 years – 60% E13 TVL) within the DFG funded project; Functional biomechanics of the healthy and degenerative meniscus;
Start date: as soon as possible.
The aim of the project is to determine the biomechanical properties of the degenerative meniscus in vivo using imaging methods (MRI). Existing in vitro methods (Freutel 2014) have to be adapted to the in vivo setting with patients. The applicant will perform experimental studies in vitro and in vivo and to a considerable extent in silico analyses.
The applicant should
– have a Master Degree in Mechanical or Biomedical Engineering, Computer Science or equivalent.
– have experience in Matlab, Finite Element Analysis (ANSYS or ABAQUS) and in using segmentation tools.  Nice to have: experience in imaging techniques.
– be an excellent team worker with above-average communication skills
– speak English very well. We expect foreigners to learn German once they have started the job.
– be autonomously working and highly motivated.
We offer
– top level research possibilities.
– excellent supervision.
– a motivated and collegial team.
The University aims to increase the number of female employees and particularly asks qualified female candidates to apply. Disabled and handicapped female applicants are preferred when equally qualified. The recruitment is made by the administration of Ulm University Medical Centre on behalf of the Federal State of Baden-Wuerttemberg.
Applications are welcome by email. Please send one single PDF including all documents.
Prof. Dr. Lutz Dürselen
Institut für Unfallchirurgische Forschung und Biomechanik
Zentrum für Traumaforschung Ulm ZTF
Universitätsklinikum Ulm
Helmholtzstrasse 14
89081 Ulm
Phone: +49 731 500-55333
E-Mail: lutz.duerselen(at)uni-ulm.de

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Doctoral student in Biomedical Engineering

Lund University, Faculty of Engineering, LTH, Biomedical Engineering

Lund University was founded in 1666 and is regularly ranked as one of the world’s top 100 higher education institutions. The University has 41 000 students and 7 500 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

LTH forms the Faculty of Engineering at Lund University, with approximately 9 000 students. The research carried out at LTH is of a high international standard and we are continuously developing our teaching methods and adapting our courses to current needs.

Project description

Can neutron scattering elucidate mechanisms behind bone damage?

Bone, with an inorganic strong and stiff mineral (hydroxyapatie) and a more flexible organic matrix (collagen type I), is a hierarchical tissue with unique material properties. During aging, many conditions occur which are treated with metal implants. E.g. joint replacements has generally evolved to be a success. However, patients still experience implant loosening due to insufficient bone in-growth, or local bone damage and failure close to the implant. Thus, improved bone ingrowth onto metal implants is still needed.

Without doubt, X-ray based imaging modalities are state-of-the-art for investigating bone both in daily clinical practice and in high end research. However, when metal implants are involved, the high density contrast between metal and bone often results in significant artifacts in the close proximity of the implant, i.e. in the most important region for evaluation bone-implant in-growth. Moreover, we have shown that bone fragility may be highly linked to changes in the collagen matrix, something that is not well captured with X-rays. The absorption profile of neutrons is however very different. Neutrons are more strongly attenuated by hydrogen and organic material than e.g. metals, but their potential in bone research has not yet been explored.

The objectives are to understand bone damage and fracture mechanisms on various hierarchical levels and with focus on bone ingrowth on implants, the goal of this project is to explore the potential of neutron tomographic imaging and small angle scattering in studies of bone.

The project includes designing and carry out experiments at large scale facilities, followed by data analysis. The imaging part involves using Digital Image Correlation to follow the deformation of the tissue during loading, and to link the different length scales of the tissue to each other. The project will develops the use of neutron based methods on bone. As such it will open up the field of neutrons to a large potential user group interested in musculoskeletal and medical materials.

SwedNESS: The project is a part of SweNESS, the newly initiated national graduate school for Neutron research. Please see link for more information http://swedness.se/

Work duties

The main duties of doctoral students are to devote themselves to their research studies which includes participating in research projects and third cycle courses. The work duties can also include teaching and other departmental duties (no more than 20%).

Detailed description of the work duties, such as:

  • The research involves both experimental design and testing, tomographic and scattering imaging and analysis of data, including the use of digital image correlation.
  • The doctoral student is expected to assist in supervision of MSc degree projects
  • The project is a collaboration with Solid mechanics and Physical Chemistry at LU, and the doctoral student is expected to actively manage this collaboration.
  • The doctoral student is expected to take part in the activities arranged by SweNESS graduate school.

Admission requirements

A person meets the general admission requirements for third-cycle courses and study programmes if he or she:

  • has been awarded a second-cycle qualification, or
  • has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits

were awarded in the second cycle, or

  • has acquired substantially equivalent knowledge in some other way in Sweden or abroad.
  • A person meets the specific admission requirements for third cycle studies in Biomedical Engineeringif he or she has at least 45 second-cycle credits of relevance to the subject.

Additional requirements:

  • Very good oral and written proficiency in English.
  • The candidate should have a background in (bio)engineering/ physics/chemistry or imaging.
  • Experience with Neutron or Synchrotron based data collection or analysis is considered important
  • Experience with tomographic imaging or small angle scattering is considered important.
  • Experience with full-field strain measurement techniques is considered positive.

Assessment criteria

Selection for third-cycle studies is based on the student’s potential to profit from such studies. The assessment of potential is made primarily on the basis of academic results from the first and second cycle. Special attention is paid to the following:

  • Knowledge and skills relevant to the thesis project and the subject of study.
  • An assessment of ability to work independently and to formulate and tackle research problems.
  • Written and oral communication skills.
  • Other experience relevant to the third-cycle studies, e.g. professional experience. Other assessment criteria:
  • The candidate should be able to independently drive his/her own research project, as well as writing scientific publications.
  • The candidate should be able to supervise younger researchers.
  • Experience with multidisciplinary projects is important.
  • International experience is considered positive.

Consideration will also be given to good collaborative skills, drive and independence, and how the applicant, through his or her experience and skills, is deemed to have the abilities necessary for successfully completing the third cycle programme.

Conditions

Only those admitted to third cycle studies may be appointed to a doctoral studentship. Third cycle studies at LTH consist of full-time studies for 4 years. A doctoral studentship is a fixed-term employment of        a maximum of 5 years (including 20% departmental duties). Doctoral studentships are regulated in the Higher Education Ordinance (1998:80).

Instructions on how to apply

Applications shall be written in English and include a cover letter stating the reasons why you are interested in the position and in what way the research project corresponds to your interests and educational background. The application must also contain a CV, degree certificate or equivalent, and other documents you wish to be considered (grade transcripts, contact information for your references, letters of recommendation, etc.).

Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset.

Type of employment                              Temporary position longer than 6 months

First day of employment                       As per argreement. Initially 1 year and thereafter extended

Salary                                                     Monthly salary

Number of positions                             1

Working hours                                      100 %

City                                                         Lund

County                                                   Skåne län

Country                                                  Sweden

Reference number                                 PA2016/4605

Contact                                                   Hanna Isaksson +46462221749 Johan Nilsson +46462227532

Published                                               2016-12-19

Last application date                            2017-01-31

Link to ad                                                http://lu.mynetworkglobal.com/what:job/jobID:127473/

 

 


Two PhD candidate vacancies in computational biomechanics at Lund University

 

We are looking for two PhD students to Biomechanics at Lund University that would like to apply to the new graduate school for Biomedical Engineering and Medical Physics, funded partly by the European Union and Marie Skłodowska-Curie actions.

The main topics of the projects are briefly described below. Any eligible candidates (please see call for the graduate school) are encouraged to contact Dr Isaksson below, with a brief CV and potential recommendations, for more information.

Hanna Isaksson, Ph.D. hanna.isaksson@bme.lth.se

http://bme.lth.se/research-pages/biomechanics/biomechanics/

PhD student 1: Computational modelling and image processing of bone strength and hip fracture risk assessment 

Project: 

Osteoporosis is defined as low bone mass, and results in a markedly increased risk of skeletal fractures. Development of new drugs to reduce bone loss or increase bone mass is promising. However, it requires that the individuals at risk can be accurately identified. Current osteoporosis diagnostics is largely based on measurements of bone mineral density (BMD), using 2D image obtained with dual energy X-ray absorptiometry (DXA). Novel methods that account for all characteristics of the bone and their influence on the bone’s resistance to fracture are needed.

The overall objectives are to integrate functional imaging of bone (clinical imaging together with mechanical modelling of bone strength) to improve prediction of fracture risk. This will be accomplished by combining DXA images with a pre-developed shape model, and finite element analysis (FEA).

First, clinical images with different resolution and level of details (ranging from DXA to high resolution cone beam CT) will be used to develop computational models using FEA. It will allow determination of the required features (e.g. anisotropy, cortical thickness, etc) to for accurate prediction of bone strength. Validation will be achieved by comparison with existing experimental mechanical testing data. Secondly, the findings will be implemented in a statistical shape and appearance model to determine if the modelling can lead to a more accurate prediction of fracture risk.

The project includes primarily numerical studies, but also involves some experimental work. It is a collaborative project with a 3 months secondment period at University of Eastern Finland, Kuopio, Finland.

PhD student 2: Computational modelling of Achilles tendon biomechanics and mechanobiology 

Project: 

Tendons connect muscles to bones and enable energy-efficient locomotion. The Achilles tendon is the largest and the most commonly injured tendon in the human body. Ruptures often occur during recreational sport activities, but can also be a result of ageing. Mechanical loading is a prerequisite for tendon healing. Controversial and often unsuccessful treatments of tendon

ruptures could be improved by elucidating how loading affects the biomechanics of intact tendons and the mechanobiological aspects of tendon healing.

The aim is to investigate how mechanical loading influences homeostatic and healing tendon function, structure and composition. The project includes refining and further validating an existing constitutive model for intact rat Achilles tendons. This will be conducted based on newly collected experimental data and focus on the fibre recruitment process and damage mechanisms in tendons. Next in the order is to develop and validate an adaptive mechanoregulatory model for tendon repair. The development of a computational mechanobiological scheme to predict the influence of mechanical loading on tendon tissue regeneration will be key to the project, in order to help elucidate the mechanobiological mechanisms at play.

The project involves primarily numerical studies and is a collaborative project with a 3 month secondment period at University of Eastern Finland, Kuopio, Finland.

Requirements for both PhD students 

The successful candidates should be eligible to be admitted to the graduate school and also has the following:

Essential qualifications

– MSc degree (or close to graduating) in biomedical engineering, medical physics, mechanical engineering, or other relevant field.

– The mobility rules of the EU funded graduate school require that a PhD student cannot have resided for more than 12 months over the past 3 years in the country which he/she applies to.

Advantageous qualifications

– Knowledge and experience in biomechanics, finite element analysis, matlab and image processing.

– Documented ability to express yourselves in English in speech and writing, to work independently, and to work effectively in a multidisciplinary team, e.g. during the M.Sc. thesis.

Primary supervisor 

Hanna Isaksson, Ph.D. Associate professor Department of Biomedical Engineering Lund University Box 118, 221 00 Lund, Sweden Email: hanna.isaksson@bme.lth.se Web: http://bme.lth.se/staff/isaksson-hanna Web: http://bme.lth.se/research-pages/biomechanics/biomechanics/

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10 PhD positions in the doctoral school BIOINTERFACE at TU Wien (Austria)

 

Within BIOINTERFACE – a newly created doctoral training program at TU Wien, Austria – ten PhD positions are available . BIOINTERFACE is a highly interdisciplinary doctoral training porogram, which aims at exploring the interface between inorganic and bio-organic systems towards applications in bio- nanotechnology. Short descriptions of the ten PhD projects are available at the BIOINTERFACE webpage under the following link:

http://biointerface.tuwien.ac.at/doctoral-training-program/phd-projects/

What we offer:

Ten three- year Ph D positions, starting between October 1 st 2016 and March 31 st 2017 , in the fields of chemical synthesis, experimental (bio-)physics/engineering as well as biomechanics, and theory/simulation. The positions are equivalent to a part-time university assistant (25 hours) position (minimum salary is EUR 1.685,30- pre-tax, 14x per year). The salary can be raised according to previous experience in the field. BIOINTERFACE provides highly interdisciplinary research projects and a cutting- edge training program including monthly seminars, lab rotation, retreats, a stay abroad, and – if applicable – industrial cooperation.

Application  Requirements:

A Diploma/Masters/Magister university degree in chemistry, ( bio-)physics, civil engineering, mathematics, biology, electrical engineering,  process  engineering,  biomedical engineering, materials science, mechanical engineering, or a related discipline is a prerequisite for becoming a BIOINTERFACE PhD student. Additional knowledge related to the specific projects is desirable.

How to apply:

Applications should be submitted in German or English language via email to:  pi.biointerface@tuwien.ac.at. Please send a single pdf-file, named “givenname_surname.pdf” The deadline for application is: September 30 2016 .

Applications must include:

  1. curriculum vitae including a list of publications, conference contributions, and other scientific activities (if applicable)
  2. transcripts of records of the Bachelor- and Master-studies
  3. title and a short summary of the diploma/master thesis
  4. two letters of reference, of which one from MSc thesis advisor
  5. cover-letter including the specification of two preferred PhD projects (please indicate 1st and 2nd choice from the list of projects at http://biointerface.tuwien.ac.at/doctoral-training-program/phd- projects/) and a motivation for your choice.

For informal questions please contact:

Gerhard Kahl, Institute for Theoretical Physics (gerhard.kahl@tuwien.ac.at), Gerhard Schütz, Institute of Applied Physics (gerhard.schuetz@tuwien.ac.at), or

Miriam M. Unterlass, Institute of Materials Chemistry (miriam.unterlass@tuwien.ac.at).

TU Wien is an equal opportunity employer aiming to increase the proportion of women within scientific and artistic staff and thus strongly encourages qualified women to apply. Female applicants will be considered preferentially, if their abilities, aptitude and professional performance are equal with those of male applicants. Persons with disabilities are especially encouraged to apply.

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PhD student in vascular biomechanics

School of Engineering Sciences, KTH Royal Institute of Technology

KTH Royal Institute of Technology in Stockholm is the largest and oldest technical university in Sweden. No less than one-third of Sweden’s technical research and engineering education capacity at university level is provided by KTH. Education and research spans from natural sciences to all branches of engineering and includes architecture, industrial management and urban planning. There are a total of almost 11,500 first and second level students and almost 1,900 doctoral students. KTH has 4,900 employees.

KTH Engineering Sciences carries out a wide range of research at the international front line, from fundamental disciplines such as Physics and Mathematics, to Engineering Mechanics with applications such as Aeronautics and Vehicle Engineering. We also offer university degree programs in Engineering Physics, Vehicle Engineering, and ‘Open entrance’, as well as a number of international master programmes.

Job description

The formation of aortic aneurysms is the by far the most common aortic disease and its prevalence (1.7%-8.9% in the 65+ population) strongly increases with age. If untreated aneurysm may rupture, often with catastrophic consequences for the patient. Consequently, about 60k elective aneurysm repair interventions are performed per year in Europe in order to prevent aortic aneurysms from rupture. However, the need for such costly and intense interventions is based oversimplified criteria like the maximum transverse aortic diameter or the aortic expansion rate. Recent scientific results indicated that aneurysm biomechanics could usefully complement clinical decision making, i.e. provide clinicians with objective and individual diagnostic information. The announced PhD position revises available models by integrating key biomechanical mechanisms towards predicting the expansion of individual aneurysms over time. Structural and hemodynamic aspects are addressed and model predictions are validated against clinical data. The work is carried out in collaboration with Karolinska University Hospital, Stockholm, Sweden and The Johns Hopkins University, Baltimore, US. The employment covers 5 years and includes 20% department duties.

Qualifications

A suitable background for this position would be a Master of Science in Engineering/Bioengineering, where a specialization in computational engineering methods, soft tissue biomechanics and bio-fluids are regarded as advantageous qualifications. In addition to the traditional academic merits, a relevant degree project, international experience, and language skills are regarded as advantageous qualifications.

Applicants must be strongly motivated for doctoral studies, possess the ability to work independently and perform critical analysis as well as possessing good levels of cooperative and communicative abilities.

Application

Send your application to gasser@kth.se. You are the main responsible to ensure that your application is complete according to the ad. Your complete application must be received at KTH no later than the last day of application.

The application must contain the following documents in PDF format.

1. Statement of professional interest

2. CV

3. Transcripts from university/university college

4. Example of technical writing, e.g., thesis, essay, course report or scientific paper

Contact: Prof. T.Christian Gasser, Phone: +46 8 790 7793,

E-mail: gasser@kth.se

Access: According to agreement
Last application date: position is open until filled

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The Julius Wolff Institute, Charité – Universitätsmedizin Berlin, has an opening for a PhD position in the topic of Mechanically driven cellular self-organization and soft tissue patterning in bone healing.

 

Background

Although bone is able to self-repair, in many situations its regeneration potential is impaired leading to delayed functional restoration or even non-unions. One of those situations concerns large bone defects which, if left untreated, results in limited bone tissue formation and unsuccessful healing. A peculiarity of this healing situation is that natural bone tissue patterning results in the formation of a bone capsule enclosing the medullary cavity. We have previously observed that this bone formation pattern follows collagen fiber organization that occurs much earlier during healing. The reason for this soft tissue patterning was found in cellular self-organization based on the traction forces generated by the individual cells. We have also observed that in large compared to small defects, there is a significant reduction in the levels of limb-loading induced mechanical strain under which the regeneration process takes place. Such local strains are also known to influence the structural organization of the tissue. However, it remains unknown to what extend both, traction force induced patterning and local mechanical strains within the healing region, interfere or synergistically contribute to soft tissue patterning with consequences for bone regeneration.

The aim of this project is to investigate how the two above-described mechanical aspects influence cellular and soft tissue organization representing different clinically relevant bone defect sizes. In particular, we will investigate how the mechanical/geometrical constrains in a large bone defect influence the spatial distribution of mechanical signals within the regenerating region and how those signals dictate cellular organization and soft tissue formation. We will also investigate potential ways to manipulate the mechanical environment of the healing region to influence cellular and tissue organization and prevent marrow encapsulation.

We will use an existing in vitro clamp setup to investigate cellular organization under controlled mechanical conditions which aim to replicate the physical/geometrical constrains in a large bone defect. Bioreactors will be used to apply in vivo-like cyclic mechanical loading signals and the influence of load magnitude and frequency on tissue patterning will be investigated. In vitro experiments will be coupled to computer models that determine the local mechanical strains surrounding individual cells and to better understand the dynamics of cellular self-organization and soft tissue formation under load.

Profile

– A degree in Mechanical Engineering/Physics/Biophysics or a related discipline

– Knowledge of Finite Element Modelling

– Experience in Programming (e.g. C/C++, Matlab)

– Previous experience in in vitro cell culture experiments will be advantageous

– High motivation and strong interest in research

 

Apply
As a PhD student you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international students.
Starting date: as soon as possible.

 

Interested candidates should send a resume, a brief letter discussing future goals and fit for the position, and two references that could be contacted. Please email the application to Prof. Dr. Sara Checa (sara.checa@charite.de).

 

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The Julius Wolff Institute, Charité – Universitätsmedizin Berlin, has an opening for a PhD position in the topic of Multiscale Computer Modeling of Bone Regeneration.

 

Background

Although bone is able to self-repair after a fracture, in many situations its regeneration capacity is impaired, leading to delayed or non-unions, followed by expensive and painful secondary interventions. The unique process of bone healing is highly complex and dynamic and spans many different time and length scales. Processes at the intracellular, cellular and tissue scales are coordinated and interact to achieve bone restoration. At the intracellular level, a complex array of signalling molecules interact giving rise to the activation of specific genes which ultimately determine cell function. At the cellular level, cells proliferate, migrate, differentiate and synthesize extracellular matrix. At the tissue level bone, cartilage and fibrous tissue are organized providing the extracellular environment for the cells. Elucidating how the different processes interact between and within the different scales and how they are altered in impaired conditions might provide a unique opportunity in the design of clinical strategies for the treatment of bone fractures. Therefore, in this project we will develop and utilize multiscale computer models of bone healing to investigate the biological interactions taken place during bone regeneration and explore possible mechanisms leading to impaired conditions.

 

Profile
– A degree in Mechanical Engineering/Computer Science/Mathematical Biology/Biophysics or a related discipline

– Experience in Programming is required (e.g. C/C++, Matlab)

– Previous experience in computer modeling of biological processes will be advantageous

– Knowledge of Finite Element Modelling will be advantageous

– High motivation and strong interest in research
Apply
As a PhD student you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international students.
Starting date: as soon as possible.

 

Interested candidates should send a resume, a brief letter discussing future goals and fit for the position, and two references that could be contacted. Please email the application to Prof. Dr. Sara Checa: sara.checa@charite.de

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Quantifying cellular forces during blood vessel formation

For more information please click on:
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EU-funded doctoral programme

There is a EU-funded doctoral programme (I4Future = Novel Imaging and Characterisation Methods in Bio, Medical and Environmental Research and Technology Innovations) coordinated by University of Oulu. It is possible to get a fully paid 4-year doctoral student position through this programme, and Simo’s research group is one of the possible places for the applicants. The candidates cannot have resided for more than 12 months in the last 3 years in Finland, so this limits the applicants to students outside Finland. Full details of the programme can be found from here: http://www.oulu.fi/i4future/node/34377

The deadline for the applications is on 31.7.2016, and the Ph.D. projects will begin in January 2017.

 

 

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Empa – the place where innovation starts

Empa is the research institute for materials science and technology of the ETH Domain and conducts cutting-edge research for the benefit of industry and the well-being of society.
Our Laboratory for Mechanics of Materials and Nanostructures is looking for a

PhD Student in the field of Biomechanical Engineering

Your Tasks

You will work on a research project funded by the Swiss National Science Foundation that will contribute to the understanding of the role of microstructure in bone strength and its impact on osteoporosis. You’ll exploit the micromechanical yield- and postyield properties of bone on the level of the extracellular matrix (ECM). During the course of the project, you will be involved in the development of an experimental setup for testing of bone extracellular matrix, sample preparation, conducting micromechanical experiments, as well as statistical data analysis and interpretation.

The project is initiated in cooperation with Prof. Philippe Zysset of the Institute of Surgical Technology and Biomechanics of the University of Bern and Prof. Kurt Lippuner of the Osteoporosis Clinic of the Inselspital.

Your Profile

You must hold a Master’s Degree or an equivalent Degree in Mechanical or Biomedical Engineering, Physics, Materials Science, or Mechanics. A high motivation to work at the leading edge of measurement science and to work in international, and multidisciplinary research teams are essential. Knowledge of English (oral and written) is important and knowledge of German would be an advantage. Experience in nanomechanical testing techniques like nanoindentation, electron microscopy based techniques, as well as programming (e.g. Labview, Python, Matlab) is desirable.
For more information please visit

https://apply.refline.ch/673276/0700/pub/4/index.html,

contact Dr. Jakob Schwiedrzik, jakob.schwiedrzik@empa.ch or Dr. Johann Michler, Johann.Michler@empa.ch

We are looking forward to your application including a letter of motivation, your CV, diplomas and two to three academic references with contact details.

Please submit your application online and upload all documents (“pdf”-file is recommended) through this webpage:

https://apply.refline.ch/673276/0700/pub/4/index.html.

Any other way of applying will not be considered.

 

 

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PhD Posi on in Biomechanics at Heriot-Wa University

With respect to its socio-economic burden osteoporosis is amongst the top ve most detrimental diseases a ec ng modern socie es. A constantly increasing live expectancy and millions of pa ents su ering from the disease necessitate an e cient management of those pa ents. During the last decades extensive research was conducted to understand the mechanical behaviour of bone. On the macro-level the elas c and the irreversible mechanical behaviour of bone ssue is well understood and allows to determine s ness and strength of whole bones and bone-implant compounds in a pa ent speci c manner. At the lower level of ssue organisa on the mechanical behaviour of bone ssue is not yet understood. Understanding bone ssue at these length scales is crucial for the design of sca old structures, bone replacements, or novel implant solu ons.

The school of Engineering and Physical Sciences of Heriot-Wa University is currently establishing a laboratory for hierarchical materials tes ng from the microscale to the macroscale including a state- of-the-art prepara on room for biological hard and so ssues. Within this e ort a fully funded PhD- posi on (£15000/year) for 42 months is available. The successful candidate will work in a mul disciplinary project involving microscopic machining, tes ng (including XRD), imaging, and simula on in the laboratory at Heriot-Wa University and at the European Synchrotron Radia on Facility in Grenoble/France. Stays up to eight weeks abroad at partner ins tu ons are necessary.

We look for a candidate with a strong background in Physics, Material Science/Mechanics, or Tissue Biomechanics. The candidate should hold a MSc or an equivalent degree in a strongly related eld. Good spoken and wri en English is mandatory. The candidate must be a UK or EU resident. Any residency other than that cannot be accepted.

Edinburgh, also called Athens of the North, is the vibrant capital of Scotland located at the shores of the Firth of Forth. It is known for its marvellous historical city centre, some of UK’s top universi es, its fascina ng fes val season, its radiant cultural ameni es, and its open minded welcoming people. Even though one has to learn a dozen or so descrip ons for the rapid change of sun and rain it is a top place to do a PhD. Please send your applica on including a le er of mo va on, a complete CV, academic records and a copy of your MSc-Thesis (either in English, German, French, or Dutch) to Uwe Wolfram under the address given above.

More information PhD-at-HWU