Category Archives: Post-doc positions

Post-Doc in Qualification of in silico-augmented clinical trial approach @ University of Bologna

Title: Qualification of in silico-augmented clinical trial approach to the efficacy assessment of new tuberculosis therapies in developing countries

Tutor: Prof Marco Viceconti – https://www.unibo.it/sitoweb/marco.viceconti/

Funding source: STriTuVaD project – https://cordis.europa.eu/project/rcn/212940_en.html

To apply: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx?strid=961

Deadline: 9 January 2019, 12:00 (applications must be sent by post or delivered by hand)

Research Project

In the framework of the STRITUVAD project partner University of Catania is developing a sophisticated simulation of the human immune system that can predict how a patient will respond to the disease activation of the Mycobacterium Tuberculosis bacterium already present in his/her body in term of bacterial spread, as a function of the patient general immune condition, and to the inoculation of specific therapies. The project goal is to refine this model so that it can:

  1. predict with sufficient accuracy the change in bacterial load over time in individual patients treated with different therapies;
  2. generate a cohort of “virtual patients” that well represent the inter-subject variability of all determinants that affect the disease progression and the response to therapy;
  3. develop in collaboration with the University of Sheffield a Bayesian statistical model that combines observational results from a clinical trial to the in silico-predicted response on the virtual patients cohort into an in silico-augmented clinical trial aimed to shorted the duration and the number of physical patients enrolled;
  4. validate the results of the in silico augmented trial to those of a full sized standard clinical trial, so to produce sufficient evidences to qualify the in silico method for studies of future drugs.

Under the guidance of Prof Marco Viceconti, one of the top experts of in silico trials worldwide, the post holder, a post-doctoral researcher with documented experience in modelling and simulation in biomedicine, will conduct the research activities described above in close collaboration with the model developers in Catania, the statistical modelling experts in Sheffield, and the clinical trialists in New Delhi.

The research contract (Assegno di Ricerca), has an annual salary before taxes of € 26,174.00. While the initial contract is for 12 months, if successful the post holder contract will be extended until the end of the project, in July 2022.

The ideal candidate for this position holds a PhD in math, physics, or engineering, documented experience in modelling and simulation in biomedicine, excellent spoken and written English, and one or more of the following skills:

  • Familiarity with the mathematical modelling of the immune system
  • Familiarity with Bayesian statistics and Bayesian modelling
  • Previous experience with biomedical regulatory science
  • Previous experience with verification, validation, and uncertainty quantification of predictive models in biomedicine

If you are interested apply here: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx?strid=961 or contact me by email for further information.

For original post see:
https://www.unibo.it/sitoweb/marco.viceconti/avvisi/fa93fd8b

Post-doc in Development of an open source software for the multiscale orchestration @ University of Bologna

Title: Development of an open source software for the multiscale orchestration of computational oncology simulations

Tutor: Prof Marco Viceconti – https://www.unibo.it/sitoweb/marco.viceconti/

Funding source: H2020 project PRIMAGE (SC1-PM-16-2017-826494)

To apply: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx?strid=961

Deadline: 9 January 2019, 12:00 (applications must be sent by post or delivered by hand)

Research Project

In 2017 the European Commission called for proposals on the topic “In-silico trials for developing and assessing biomedical products”; one of the projects funded, PRIMAGE, which will start on December 1st, 2018, aims to develop in silico trials technologies to test the efficacy of new anti-tumour therapies. To predict the response of a new anti-cancer agent over a representative clinical population is a very complex endeavour, which requires a detailed model of the biochemical mechanism of action of the new drug on the cancer cells, another model that describe how this effect modulate the cell-to-cell and the cell-to-tissue interaction and signalling, and another model that can predict the overall growth of the tumour mass over time, its vascularisation, and its cellularity. As each of these models is defined at radically different space-time scales, their coupling is complex and involves an advanced orchestration to build a multiscale simulation.

This problem has been approached in different ways in the past by Prof Viceconti’s team and by other research groups, but all solutions so far have been not entirely satisfactory. The main problem is that the software stack to handle this orchestration becomes rapidly very large and complex (thus difficult to maintain), and strongly dependent on implementations of the models being orchestrated; as in most projects these are being developed in parallel, this create some serious difficulties.

In PRIMAGE we intend to tackle a completely different approach loosely inspired by the High Level Architecture approach standardised by IEEE Std 1516-2010, and popular especially in the context of defence research. We intend to develop a very simple and easy to maintain architecture that orchestrate the models by controlling their data flow, centralising in a database all intermediate data objects, so as to explore possible speed-up strategies based on pre-computation, interpolation, and surrogate modelling methods. The result will be an open source software tool that should make much easier for research groups around the world to design and deploy complex multiscale orchestrations, that execute efficiently and flexibly in different execution environments.

Under the guidance of Prof Marco Viceconti, one of the top experts of in silico trials and biomedical multiscale modelling worldwide, the post holder, a researcher with documented experience in software development in Python, will design and develop this orchestration framework, and use it to deploy a large scale multiscale simulation that orchestrate models developed by specialists at partners ANSYS, UNIVERSITY OF SARAGOZA, UNIVERSITY OF SHEFFIELD, and CHEMOTARGETS, which will be tested as in silico trial solution.

The research contract (Assegno di Ricerca), has an annual salary before taxes of € 26,174.00. While the initial contract is for 12 months, if successful the post holder contract will be extended until the end of the project, in November 2022.

The ideal candidate for this position holds a degree in computer science, math, physics, or engineering, documented experience in software development in Python, good spoken and written English, and one or more of the following skills:

  • Familiarity with computational science & engineering software development
  • Familiarity with computational biomedicine software development
  • Previous experience with model orchestration and/or multiscale modelling
  • Previous experience with database software development, NoSQL databases, blockchain public ledgers, surrogate modelling, and/or machine learning
  • Previous experience with Open Source projects management

If you are interested apply here: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx?strid=961 or contact me by email for further information.

For the original post see:
https://www.unibo.it/sitoweb/marco.viceconti/avvisi/4c20aa93

Posdoc Position in characterization and modeling of elastic protein @ Université de Lyon (France)

Mechanical characterization and modeling of a synthetic elastic protein and its effects on the arterial function

A post-doctoral fellowship is available at the Center for Biomedical and Healthcare Engineering Mines Saint-Etienne – SAINBIOSE (INSERM-U1059) – Université de Lyon (France).

Scientific context: Elastin is the main elasticity provider for several soft tissues (such as dermis, arteries, pulmonary alveoli) in its fibrous form and a signaling molecule in cell/extracellular matrix interaction. Elastin-rich elastic fibers allow the large artery walls to transform the pulsatile blood flow ejected by the heart into a continuous blood flow in the peripheral arteries (Windkessel effect). Dysfunctions are highly correlated with diseases such as artery stenosis, aneurysm, hypertension or cardiac hypertrophy, which have strong repercussions on arterial biomechanics and can threaten the vessel integrity.
Setting aside surgery, there is currently no treatment for preventing, blocking or treating any loss of elasticity. It therefore appears, from a biomechanical point of view, that the introduction of an entity that provides elasticity within the arterial wall would be the most trivial action to stop arterial stiffening, but remains currently limited due to chemo-biological issues. The Arterylastic project, to which the thesis is linked, proposes to unlock this technological barrier using an original synthetic elastic protein (SEP) recently developed with a synthetic backbone devoted to skin engineering.

Academic context: As previously mentioned, the thesis takes place in a larger project named Arterylastic, funded by ANR, combining pluridisciplinary approaches of three laboratories in France: LBTI – the Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (UMR5305 CNRS/UCBL1 Lyon), HP2 –Hypoxie Physiopathologie Cardiovasculaire et Respiratoire (INSERM U1042 – University Grenoble Alpes) and Sainbiose (within the Center for Biomedical and Healthcare Engineering CISSAINBIOSE/INSERM U1059 – Mines Saint-Etienne). The PhD student will work at CIS, which also conducts major international research projects in the field of soft tissue biomechanics, in particular aortic aneurysms. He will collaborate with other researchers involved in ERC projects (https://www.mines-stetienne.fr/en/author/avril/, https://www.emse.fr/~badel/).

Objectives: The objective is to restore (or at least improve) arterial function and mechanical properties under conditions of elastic fibers injury. The objective will be reached if the SEP is correctly integrated into elastic fibers and if the SEP restores arterial wall elasticity and/or physiological parameters in relevant animal models. In this thesis, we will evaluate the mechanical behavior of the cross-linked SEP and of arterial samples from treated mouse models and a numerical model will be developed from experimental data to better predict treatment parameters.
The main tasks will be:
1. Experimental tests will be carried out for characterizing the macroscopic mechanical properties of the SEP and of arteries treated with the SEP. The cross-linked SEP will be characterized using tensile tests with a customized device. Mechanical parameters of treated arteries will be assessed by measuring pressure-diameter curves from mouse arteries tested in a customized tension-inflation test.
2. A multiscale numerical model of the mechanical behavior of arteries will be elaborated, taking into account their microstructural composition and morphology (bilayer, specific contributions of elastin, collagen, smooth muscle cells, possible proteoglycans) and including the effects of possible grafting of the SEP to the arterial wall. The model will be tested for arteries with competent elastic fibers, for arteries with damaged elastin and induced-tissue remodelling, and for arteries treated with the SEP.
3. The experimental results obtained at task 1 will be used to evaluate and calibrate the prediction ability of the numerical model developed in task 2. Sensitivity analysis permitting to find the optimal treatment conditions with the SEP for different types of therapeutic targets will be addressed.

Candidate profile: Candidates with strong skills in mechanics (modeling and experimental) and biomechanics are expected. Motivation and interest in bioengineering applications is recommended.

How to apply: Send CV, cover letter and letters of recommendation to claire.morin@emse.fr and avril@emse.fr.

Applications Engineer – Simpleware Software, Exeter, UK

Applications Engineer

18295BR

GREAT BRITAIN – Exeter

Job Description and Requirements

Overall purpose of job

Simpleware software is currently looking for a motivated applicant to join the technical support team. You should be passionate about working with image processing and 3D modelling software, and with providing technical knowledge and sales support. You will also be responsible for generating papers and promotional material which will require you to work very closely with customers and partners.

We offer a competitive salary for this position.

The closing date for this job posting is the 10th of September, 2018

Primarily, this will involve

  • Providing high quality and reliable technical support for our clients
  • Organising software demonstrations, workshops, and training
  • Visiting potential clients, and attending conferences and exhibitions
  • Generating proposals, papers, reports, press releases, software documentation, tutorials, etc.
  • Establishing new, and maintaining existing, long-term relationships with customers, partners and the media

Knowledge, experience, skills, and competencies

  • Qualified at least to first degree level in an Engineering related subject – preferably a first or 2:1
  • Experience using CAD, FEA (e.g. Abaqus, Ansys, Comsol, etc.) or CFD (e.g. Fluent, OpenFOAM, etc.) codes
  • Good knowledge of either image processing, biomechanical or materials modelling
  • Excellent presentation, communication and interpersonal skills
  • Strong personal organisation, with good project management skills and ability to work to deadlines
  • Strong project management ability, personal organisation and customer focus
  • Self-motivation and ability to work on own initiative whilst being a team player
  • Knowledge of scripting languages (e.g. Python) and web technologies (HTML, CSS, Java Script, PHP and MySQL) would be useful/an advantage

UPF accepts applications for Junior Leader postdocs

In its quality as a Maria de Maeztu Center of Excellent the DTIC at University Pompeu Fabra accepts applications in the The postdoctoral fellowships programme, Junior Leader “la Caixa”

 

Especially, the Biomechanics and Mechanobiology Lab of the Barcelona Centre for New Medical Technologies (BCN MedTech) is looking for applicants in any of the following fields:

  • Computational multiscale biomechanics
  • Soft/hard tissue multiphysics
  • Multibody dynamics and human movement analysis
  • Computational systems biology of musculoskeletal, arterial and pulmonar tissues
  • Image analyses and machine learning applied to computational biomechanics and systems biology

Should you be interested to apply, please contact Dr Jérôme Noailly (jerome.noailly@upf.edu)

The postdoctoral fellowships programme, Junior Leader “la Caixa” aims to hire excellent researchers—of any nationality—who wish to continue their research career in Spanish or Portuguese territory. . Sponsored by Obra Social ”la Caixa”, the objectives of this programme are to foster high-quality, innovative research in Spain and to support the best scientific talents by providing them with an attractive, competitive environment in which to conduct excellent research.

The Junior Leader programme is divided into two different frames:

  • Incoming: 22 postdoctoral fellowships for researchers of all nationalities. They will be offered a three-year employment contract to conduct a research project at accredited centres with the Severo Ochoa or María de Maeztu distinction of excellence, Institutos de Investigación Sanitaria Carlos IIII and units evaluated as excellent and exceptional by the Fundação para a Ciência e Tecnologia of Portugal. For Spanish institutions, candidates must have resided in Spain less than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal less than 12 months in the last three years.
  • Retaining: 11 postdoctoral fellowships for researchers of all nationalities to carry out research at any university or research centre in Spain or Portugal. For Spanish institutions, candidates must have resided in Spain more than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal more than 12 months in the last three years.

By means of a complementary training programme, these fellowships are intended to consolidate research skills and to foster an independent scientific career as an option for the future.

Deadline September 26th 2018!

Apply now

 

 

Postdoc position: COMPUTER MODELING OF THE MECHANO-BIOLOGICAL REGULATION OF ANGIOGENESIS @ CHARITE

Computer modeling of the mechano-biological regulation of angiogenesis

 

A post-doctoral fellowship is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin). This position is funded through a collaboration grant (Research Unit 2165: Regeneration in Aged Individuals) from the German Research Foundation (DFG) to study the mechanical regulation of sprouting angiogenesis during bone regeneration. Research goals are being addressed through a combination of in vitro/in vivo experimentation and computer modeling.

The successful candidate will have a strong background in one or more of the following areas: mechanics, bioinformatics, computational biology and/or computational mechanics. Strong programming and computer modelling skills are required. The position is available for two years with an option to renew provided that adequate progress is made and that the project funding is continued.

The work will be conducted in an interdisciplinary research environment composed of engineers, biologists and clinicians. As a postdoc you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international scientists.

 

Interested candidates should submit their curriculum vitae and two references by August 31, 2018. Applications should be sent to: Prof. Sara Checa (sara.checa@charite.de)

Postdoctoral researcher position McGill University

Posting POSTDOCTORAL RESEARCHER
Position Title: Post-Doctoral Researcher
Hiring Unit: School of Communication Sciences and Disorders
Name of Immediate Supervisor: Nicole Li-Jessen
Location of Work: 8/F, 2001 McGill College Avenue, Montreal, Canada
Work Schedule: 35 hours/ week
Working Hours: 9 a.m. – 5 p.m. (work hours negotiable)
Planned Start Date & End Date:

(if applicable)

September 2018 (possibility of three years)
Salary Range:

(minimum as per collective agreement)

CAD $42,000 – $47,000 depending on experience and qualifications
Posting Period:

(start and end date of posting)

Now
PRIMARY DUTIES
We are seeking a highly motivated junior-level postdoctoral researcher to join the Voice Research Laboratory at McGill University in Canada. This appointment is expected to begin in September 2018 (start date negotiable). The Voice Research Laboratory at McGill focuses on advancing personalized medicine in laryngology through the development of numerical simulations, wearable devices, non-invasive diagnostics and tissue engineering products. This is a unionized position   at McGill University.

The successful applicant will work on highly interdisciplinary research projects in computational biology and translational research. The primary duty of this position is to further develop existing agent-based models for vocal fold biomaterial design and tissue reconstruction. Additional training on wet lab skills, advance microscopy and tissue mechanics are available if the applicant is interested in.

 QUALIFICATIONS

A Ph.D. or equivalent degree in computational biology, biomedical engineering, or related quantitative scientific discipline is required by the time the appointment begins.

The applicant should have expertise and experience in multiscale computational modeling and analysis of biological systems. Skills in numerical simulations, e.g., development of agent-based models using C/C++ and/ or Matlab/Mathematica, experience in sensitivity analysis, model calibration and  verification, as well as implementation of mathematical descriptions of physical biological processes are required. Applicants with advanced computational training as well as knowledge of cellular biology and tissue biomechanics are preferred.

Proven track record in peer-reviewed publications in related fields is expected. Qualified candidates should be highly self-motivated and possess the ability to work independently, as well as in a multidisciplinary collaborative environment. Excellent interpersonal, organizational, and oral and written technical and scientific English communication skills are required.

The applicant will work closely with the team under direct supervision of Dr. Nicole Li-Jessen and with

our mechanical engineering and clinical collaborators at McGill University and other institutions in Canada and the United States. The applicant will have the opportunity to work on advanced, challenging research projects, primarily through development of predictive multiscale models in the field of vocal scarring and tissue engineering. If interested, the applicant can also lead or participate in relevant projects available in the lab.

Candidates are encouraged to apply by May 31, 2018. Applications will be reviewed until the position is

filled. Please send the application to Dr. Nicole Li-Jessen nicole.li@mcgill.ca.

  1. Cover letter
  2. Curriculum Vitae
  3. Research statement (1-page)
  4. Three references with contact information
  5. Publications if applicable

Postdoctoral position Bio-inspired 3D printing @ TU WIEN, Austria

POSTDOCTORAL POSITION IN BIO-INSPIRED 3D PRINTING, VIENNA UNIVERSITY OF TECHNOLOGY (TU WIEN)

3D printing has become a technology which has pervaded many application fields, having enabled the production of tiny structures with a hitherto unparalleled precision. One major drawback, however, seems to be left: mechanical integrity. Namely, the successively downlaid layers may entail inherent weaknesses. How to overcome this limitation? The present project funded by the Austrian Academy of Sciences and jointly realized by the University of Vienna and Vienna University of Technology (TU Wien) wishes to venture into this unknown territory; by targeting the mechanical secrets of the highly mechanically competent 3D printing systems employed by the large animal class of polychaetae or bristle worms. This class is still be discovered from a purely biological or genetical viewpoint, but in cooperation with world-class Vienna-based biologists, it is now the time for interdisciplinarily inclined engineering mechanicians with expertise in mechanical modeling of multiscale biological systems, to start, from a clear theoretical basis, a very first systematic experimental protocol which aims at understanding the chitin-made chaetae, or bristles, which are miracles in terms of geometrical and functional  diversity.

In this context, we announce a post-doc position for an excellent engineering mechanician (or closely related engineering scientists) who not only strives for new discoveries, but also shares the vision for combining and merging largely separated fields of research.

The post-doc position may start on June 1, 2018 for a duration of two years. The gross salary is € 3,711.10 per month.

Interested candidates should send a letter of application, curriculum vitae, and names and addresses of three references to Prof. Christian Hellmich, Christian.Hellmich@tuwien.ac.at.

Postdoctoral position at the Laboratory for Bone Biomechanics, ETH Zurich

Postdoctoral Position in Time-lapsed Imaging and Multiscale Modeling of Human Bone Fracture Healing

The aim of the research is to perform time-lapsed high-resolution CT imaging and multiscale modeling of distal radius bone fractures in patients and to investigate the in vivo healing process employing image processing and analysis. Bone fractures are very common and in 5-10% of the cases do not heal or are delayed. Nevertheless, factors influencing the healing outcome are not yet well understood. The specific aims of this 2-year project will therefore be (1) to perform high-resolution CT imaging in fracture patients and develop image analysis and registration methods to determine in vivo bone resorption and formation sites during fracture healing at the human distal radius, (2) to assess local bone remodeling and comparing the results with clinical biomarker measurements including whole bone strength through multiscale modeling approaches, and (3) to evaluate how bone remodeling during fracture healing affects whole bone strength in healthy, aged and osteoporotic humans.

The position will be based at the Inselspital Bern and at ETH Zurich. Furthermore, this project is embedded in a larger effort funded by the National Science Foundations of Switzerland, Germany, and Austria through a DACH consortium grant consisting of Ulm University (D), the Medical University Innsbruck (A), and the Inselspital Bern and ETH Zurich (CH). The overall goal of the consortium is to investigate local bone remodeling and mechanoregulation of bone fracture healing in healthy, aged, and osteoporotic humans.

The successful candidate holds or will soon receive a doctoral degree in Biomedical, Electrical or Mechanical Engineering, and has preferentially a background in imaging and image processing. It is essential that the candidate is willing and motivated to work at the interface between engineering and clinical research. Additionally, excellent communication skills in English (oral and written) are required and command of the German language is required for the clinical interactions.

We look forward to receiving your online application includinga a motivation letter, CV, university transcripts and names and contact details of two references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For further information about the group please visit our website www.bone.ethz.ch. Questions regarding the position should be directed to Dr. Patrik Christen by email patrik.christen[at]hest.ethz.ch (no applications).

Application:

https://apply.refline.ch/845721/6048/index.html?cid=1&lang=en

Postdoctoral Research Associate in Skeletal Ageing and Biomechanics at Insigneo

Postdoctoral Research Associate in Skeletal Ageing and Biomechanics at Insigneo

Job Title:
Postdoctoral Research Associate in Skeletal Ageing and Biomechanics

Description:
A position has become available for a highly motivated postdoctoral research scientist to be involved with studies to determine the effects of geroprotectors on bone and joint ageing.
You will use ex vivo X-ray microCT and histomorphometry combined with new computational approaches for an in depth structural analysis of bone, bone strength, cartilage degradation and subchondral bone changes.
The post is funded by Biotechnology and Biological Sciences Research Council (BBSRC) and will be based at the Insigneo Institute for In silico Medicine and the MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) in Sheffield.
You should hold a PhD in Engineering, Physics or related disciplines, be familiar with experimental, imaging, image processing and computational modelling techniques for assessment of bone properties. A willingness to learn histological techniques is also essential.
The post is fixed term until the end of December 2019, reporting to Dr Enrico Dall’Ara and Prof. Bellantuono

Contact: e.dallara@sheffield.ac.uk
Start position: As soon as possible
Duration: until the end of December 2019
Closing application: 25th January 2018
Link Application (use in Keywords: “UOS018139):
https://jobs.shef.ac.uk/sap/bc/webdy…ign=jobs-link#

Salary: Grade 7; £30,175 to £38,183 per annum