Category Archives: Post-doc positions

Senior Research Associate University of Portsmouth – Faculty of Science

Employment type: Fixed-term contract for 6 months

Interview date: 28 March 2019

We are seeking to appoint a Senior Research Associate (SRA) to contribute to the project “3D printing of complex scaffolds for the repair of osteochondral defects” developed in collaboration between the Biomaterials and Drug Delivery group (http://www.port.ac.uk/school-of-pharmacy-and-biomedical-sciences/research/biomaterials-and-drug-delivery/) and the Zeiss Global Centre (http://www.port.ac.uk/school-of-engineering/zeiss-global-centre/) at the University of Portsmouth.

Osteochondral lesions are painful, and predispose to osteoarthritis (OA), which is unquestionably one of the most important chronic health issues in humans, affecting an estimated 8.5 million people in the UK only. Due to the absence of vascularisation in cartilage, its regenerative capacity is limited, and treatment is required for repair. Severe limitations of current treatments, such as microfracture and autografts, have inspired research into more effective tissue engineering strategies, involving the implantation of stem cells able to repair the tissue. The implanted stem cells must be able to differentiate both into cartilage and bone cells. The differentiation of the cells can be controlled by changes in the modulus of the implant; however, there are no current scaffold materials that allow this concurrent double differentiation. We therefore propose to use our state of the art 3D bioprinter (Cellink) – able to co-print multiple materials and cells – to develop complex structures of biocompatible polymers of selected stiffness and porosity, to study how architectural and mechanical properties of the scaffold guide cells differentiation into the two types of cells desired.

The successful candidate will have a PhD degree or equivalent with experience in tissue culture in particular with stem cells, knowledge of some of the following areas is desirable: bioengineering, mechanobiology, x-ray/confocal microscopy, mechanical testing, 3D printing and biomaterial formulation. The SRA will work in a dynamic environment and benefit from the existing collaborative research between Dr Marta Roldo (expert in the synthesis, formulation and characterisation of biocompatible materials), Dr Petko Petkov (expert in mechanical and design engineering required to adapt the 3D printing process to the higher complexity of bio 3D printing) and Dr Gianluca Tozzi (X-ray computed tomography and correlative imaging).

The post is based at the School of Pharmacy and Biomedical Science, University of Portsmouth, with the appointment effective as soon as possible or no later than 1st April 2019. For informal enquiries please contact Dr Marta Roldo at marta.roldo@port.ac.uk or phone +44 (0)23 9284 3586.

Location:Portsmouth
Salary:£30,395 to £34,189 per annum
Hours:Full Time
Contract Type:Fixed-Term/Contract
Placed On:18th February 2019
Closes:9th March 2019
Job Ref:ZZ005155

webpage for applications:

https://www.jobs.ac.uk/job/BQH756/senior-research-associate

Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, Oxford

Grade 7: £32,236 – £39,609 p.a.

Applications are invited for the position of a Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering to join an interdisciplinary team of researchers collaborating on a project led by Dr Mouthuy at the Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), Oxford.

This post will be included in the activities of the Carr group as well as Professor Jerusalem’s group at the Department of Engineering Science, Oxford and Professor Waters’ group at the Mathematical Institute, Oxford and as such the postholder will be required to work across these locations.

As a Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering you will participate in the activities of the research team in the Humanoid Bioreactor project, sharing skills and knowledge and publishing your findings in peer-reviewed journals.

You will analyse, contextualise and interpret data, write and maintain programs and protocols for data analysis as well as train and supervise graduate and undergraduate students as appropriate.

You will hold a PhD/DPhil (or near completion) in a discipline of direct relevance to computational mechanics and/or tissue engineering.
You will be competent with programming languages such as C/C++ and Matlab as well as numerical simulations, model calibration and validation.
You will have an experience in implementing mathematical descriptions of physical biological processes and you will be highly self-motivated and committed to pursuing interdisciplinary research.
Experience with handling clinical imaging data such as CT, MRI or ultrasound scans, strong competences in the use of CAD software to design materials and an ability to conduct experiments with cells and biomaterials are desirable.

This is a full-time fixed-term appointment for 3 years.
You will be required to upload a CV and supporting statement as part of your online application.
The closing date for this position is 12.00 noon on Monday 18 March 2019.

More details and applications:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=139124

Posdoc Position in characterization and modeling of elastic protein @ Université de Lyon (France)

Mechanical characterization and modeling of a synthetic elastic protein and its effects on the arterial function

A post-doctoral fellowship is available at the Center for Biomedical and Healthcare Engineering Mines Saint-Etienne – SAINBIOSE (INSERM-U1059) – Université de Lyon (France).

Scientific context: Elastin is the main elasticity provider for several soft tissues (such as dermis, arteries, pulmonary alveoli) in its fibrous form and a signaling molecule in cell/extracellular matrix interaction. Elastin-rich elastic fibers allow the large artery walls to transform the pulsatile blood flow ejected by the heart into a continuous blood flow in the peripheral arteries (Windkessel effect). Dysfunctions are highly correlated with diseases such as artery stenosis, aneurysm, hypertension or cardiac hypertrophy, which have strong repercussions on arterial biomechanics and can threaten the vessel integrity.
Setting aside surgery, there is currently no treatment for preventing, blocking or treating any loss of elasticity. It therefore appears, from a biomechanical point of view, that the introduction of an entity that provides elasticity within the arterial wall would be the most trivial action to stop arterial stiffening, but remains currently limited due to chemo-biological issues. The Arterylastic project, to which the thesis is linked, proposes to unlock this technological barrier using an original synthetic elastic protein (SEP) recently developed with a synthetic backbone devoted to skin engineering.

Academic context: As previously mentioned, the thesis takes place in a larger project named Arterylastic, funded by ANR, combining pluridisciplinary approaches of three laboratories in France: LBTI – the Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (UMR5305 CNRS/UCBL1 Lyon), HP2 –Hypoxie Physiopathologie Cardiovasculaire et Respiratoire (INSERM U1042 – University Grenoble Alpes) and Sainbiose (within the Center for Biomedical and Healthcare Engineering CISSAINBIOSE/INSERM U1059 – Mines Saint-Etienne). The PhD student will work at CIS, which also conducts major international research projects in the field of soft tissue biomechanics, in particular aortic aneurysms. He will collaborate with other researchers involved in ERC projects (https://www.mines-stetienne.fr/en/author/avril/, https://www.emse.fr/~badel/).

Objectives: The objective is to restore (or at least improve) arterial function and mechanical properties under conditions of elastic fibers injury. The objective will be reached if the SEP is correctly integrated into elastic fibers and if the SEP restores arterial wall elasticity and/or physiological parameters in relevant animal models. In this thesis, we will evaluate the mechanical behavior of the cross-linked SEP and of arterial samples from treated mouse models and a numerical model will be developed from experimental data to better predict treatment parameters.
The main tasks will be:
1. Experimental tests will be carried out for characterizing the macroscopic mechanical properties of the SEP and of arteries treated with the SEP. The cross-linked SEP will be characterized using tensile tests with a customized device. Mechanical parameters of treated arteries will be assessed by measuring pressure-diameter curves from mouse arteries tested in a customized tension-inflation test.
2. A multiscale numerical model of the mechanical behavior of arteries will be elaborated, taking into account their microstructural composition and morphology (bilayer, specific contributions of elastin, collagen, smooth muscle cells, possible proteoglycans) and including the effects of possible grafting of the SEP to the arterial wall. The model will be tested for arteries with competent elastic fibers, for arteries with damaged elastin and induced-tissue remodelling, and for arteries treated with the SEP.
3. The experimental results obtained at task 1 will be used to evaluate and calibrate the prediction ability of the numerical model developed in task 2. Sensitivity analysis permitting to find the optimal treatment conditions with the SEP for different types of therapeutic targets will be addressed.

Candidate profile: Candidates with strong skills in mechanics (modeling and experimental) and biomechanics are expected. Motivation and interest in bioengineering applications is recommended.

How to apply: Send CV, cover letter and letters of recommendation to claire.morin@emse.fr and avril@emse.fr.

Applications Engineer – Simpleware Software, Exeter, UK

Applications Engineer

18295BR

GREAT BRITAIN – Exeter

Job Description and Requirements

Overall purpose of job

Simpleware software is currently looking for a motivated applicant to join the technical support team. You should be passionate about working with image processing and 3D modelling software, and with providing technical knowledge and sales support. You will also be responsible for generating papers and promotional material which will require you to work very closely with customers and partners.

We offer a competitive salary for this position.

The closing date for this job posting is the 10th of September, 2018

Primarily, this will involve

  • Providing high quality and reliable technical support for our clients
  • Organising software demonstrations, workshops, and training
  • Visiting potential clients, and attending conferences and exhibitions
  • Generating proposals, papers, reports, press releases, software documentation, tutorials, etc.
  • Establishing new, and maintaining existing, long-term relationships with customers, partners and the media

Knowledge, experience, skills, and competencies

  • Qualified at least to first degree level in an Engineering related subject – preferably a first or 2:1
  • Experience using CAD, FEA (e.g. Abaqus, Ansys, Comsol, etc.) or CFD (e.g. Fluent, OpenFOAM, etc.) codes
  • Good knowledge of either image processing, biomechanical or materials modelling
  • Excellent presentation, communication and interpersonal skills
  • Strong personal organisation, with good project management skills and ability to work to deadlines
  • Strong project management ability, personal organisation and customer focus
  • Self-motivation and ability to work on own initiative whilst being a team player
  • Knowledge of scripting languages (e.g. Python) and web technologies (HTML, CSS, Java Script, PHP and MySQL) would be useful/an advantage

UPF accepts applications for Junior Leader postdocs

In its quality as a Maria de Maeztu Center of Excellent the DTIC at University Pompeu Fabra accepts applications in the The postdoctoral fellowships programme, Junior Leader “la Caixa”

 

Especially, the Biomechanics and Mechanobiology Lab of the Barcelona Centre for New Medical Technologies (BCN MedTech) is looking for applicants in any of the following fields:

  • Computational multiscale biomechanics
  • Soft/hard tissue multiphysics
  • Multibody dynamics and human movement analysis
  • Computational systems biology of musculoskeletal, arterial and pulmonar tissues
  • Image analyses and machine learning applied to computational biomechanics and systems biology

Should you be interested to apply, please contact Dr Jérôme Noailly (jerome.noailly@upf.edu)

The postdoctoral fellowships programme, Junior Leader “la Caixa” aims to hire excellent researchers—of any nationality—who wish to continue their research career in Spanish or Portuguese territory. . Sponsored by Obra Social ”la Caixa”, the objectives of this programme are to foster high-quality, innovative research in Spain and to support the best scientific talents by providing them with an attractive, competitive environment in which to conduct excellent research.

The Junior Leader programme is divided into two different frames:

  • Incoming: 22 postdoctoral fellowships for researchers of all nationalities. They will be offered a three-year employment contract to conduct a research project at accredited centres with the Severo Ochoa or María de Maeztu distinction of excellence, Institutos de Investigación Sanitaria Carlos IIII and units evaluated as excellent and exceptional by the Fundação para a Ciência e Tecnologia of Portugal. For Spanish institutions, candidates must have resided in Spain less than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal less than 12 months in the last three years.
  • Retaining: 11 postdoctoral fellowships for researchers of all nationalities to carry out research at any university or research centre in Spain or Portugal. For Spanish institutions, candidates must have resided in Spain more than 12 months in the last three years while for Portuguese institutions, candidates must have resided in Portugal more than 12 months in the last three years.

By means of a complementary training programme, these fellowships are intended to consolidate research skills and to foster an independent scientific career as an option for the future.

Deadline September 26th 2018!

Apply now

 

 

Postdoc position: COMPUTER MODELING OF THE MECHANO-BIOLOGICAL REGULATION OF ANGIOGENESIS @ CHARITE

Computer modeling of the mechano-biological regulation of angiogenesis

 

A post-doctoral fellowship is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin). This position is funded through a collaboration grant (Research Unit 2165: Regeneration in Aged Individuals) from the German Research Foundation (DFG) to study the mechanical regulation of sprouting angiogenesis during bone regeneration. Research goals are being addressed through a combination of in vitro/in vivo experimentation and computer modeling.

The successful candidate will have a strong background in one or more of the following areas: mechanics, bioinformatics, computational biology and/or computational mechanics. Strong programming and computer modelling skills are required. The position is available for two years with an option to renew provided that adequate progress is made and that the project funding is continued.

The work will be conducted in an interdisciplinary research environment composed of engineers, biologists and clinicians. As a postdoc you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international scientists.

 

Interested candidates should submit their curriculum vitae and two references by August 31, 2018. Applications should be sent to: Prof. Sara Checa (sara.checa@charite.de)

Postdoctoral researcher position McGill University

Posting POSTDOCTORAL RESEARCHER
Position Title: Post-Doctoral Researcher
Hiring Unit: School of Communication Sciences and Disorders
Name of Immediate Supervisor: Nicole Li-Jessen
Location of Work: 8/F, 2001 McGill College Avenue, Montreal, Canada
Work Schedule: 35 hours/ week
Working Hours: 9 a.m. – 5 p.m. (work hours negotiable)
Planned Start Date & End Date:

(if applicable)

September 2018 (possibility of three years)
Salary Range:

(minimum as per collective agreement)

CAD $42,000 – $47,000 depending on experience and qualifications
Posting Period:

(start and end date of posting)

Now
PRIMARY DUTIES
We are seeking a highly motivated junior-level postdoctoral researcher to join the Voice Research Laboratory at McGill University in Canada. This appointment is expected to begin in September 2018 (start date negotiable). The Voice Research Laboratory at McGill focuses on advancing personalized medicine in laryngology through the development of numerical simulations, wearable devices, non-invasive diagnostics and tissue engineering products. This is a unionized position   at McGill University.

The successful applicant will work on highly interdisciplinary research projects in computational biology and translational research. The primary duty of this position is to further develop existing agent-based models for vocal fold biomaterial design and tissue reconstruction. Additional training on wet lab skills, advance microscopy and tissue mechanics are available if the applicant is interested in.

 QUALIFICATIONS

A Ph.D. or equivalent degree in computational biology, biomedical engineering, or related quantitative scientific discipline is required by the time the appointment begins.

The applicant should have expertise and experience in multiscale computational modeling and analysis of biological systems. Skills in numerical simulations, e.g., development of agent-based models using C/C++ and/ or Matlab/Mathematica, experience in sensitivity analysis, model calibration and  verification, as well as implementation of mathematical descriptions of physical biological processes are required. Applicants with advanced computational training as well as knowledge of cellular biology and tissue biomechanics are preferred.

Proven track record in peer-reviewed publications in related fields is expected. Qualified candidates should be highly self-motivated and possess the ability to work independently, as well as in a multidisciplinary collaborative environment. Excellent interpersonal, organizational, and oral and written technical and scientific English communication skills are required.

The applicant will work closely with the team under direct supervision of Dr. Nicole Li-Jessen and with

our mechanical engineering and clinical collaborators at McGill University and other institutions in Canada and the United States. The applicant will have the opportunity to work on advanced, challenging research projects, primarily through development of predictive multiscale models in the field of vocal scarring and tissue engineering. If interested, the applicant can also lead or participate in relevant projects available in the lab.

Candidates are encouraged to apply by May 31, 2018. Applications will be reviewed until the position is

filled. Please send the application to Dr. Nicole Li-Jessen nicole.li@mcgill.ca.

  1. Cover letter
  2. Curriculum Vitae
  3. Research statement (1-page)
  4. Three references with contact information
  5. Publications if applicable

Postdoctoral position Bio-inspired 3D printing @ TU WIEN, Austria

POSTDOCTORAL POSITION IN BIO-INSPIRED 3D PRINTING, VIENNA UNIVERSITY OF TECHNOLOGY (TU WIEN)

3D printing has become a technology which has pervaded many application fields, having enabled the production of tiny structures with a hitherto unparalleled precision. One major drawback, however, seems to be left: mechanical integrity. Namely, the successively downlaid layers may entail inherent weaknesses. How to overcome this limitation? The present project funded by the Austrian Academy of Sciences and jointly realized by the University of Vienna and Vienna University of Technology (TU Wien) wishes to venture into this unknown territory; by targeting the mechanical secrets of the highly mechanically competent 3D printing systems employed by the large animal class of polychaetae or bristle worms. This class is still be discovered from a purely biological or genetical viewpoint, but in cooperation with world-class Vienna-based biologists, it is now the time for interdisciplinarily inclined engineering mechanicians with expertise in mechanical modeling of multiscale biological systems, to start, from a clear theoretical basis, a very first systematic experimental protocol which aims at understanding the chitin-made chaetae, or bristles, which are miracles in terms of geometrical and functional  diversity.

In this context, we announce a post-doc position for an excellent engineering mechanician (or closely related engineering scientists) who not only strives for new discoveries, but also shares the vision for combining and merging largely separated fields of research.

The post-doc position may start on June 1, 2018 for a duration of two years. The gross salary is € 3,711.10 per month.

Interested candidates should send a letter of application, curriculum vitae, and names and addresses of three references to Prof. Christian Hellmich, Christian.Hellmich@tuwien.ac.at.

Postdoctoral position at the Laboratory for Bone Biomechanics, ETH Zurich

Postdoctoral Position in Time-lapsed Imaging and Multiscale Modeling of Human Bone Fracture Healing

The aim of the research is to perform time-lapsed high-resolution CT imaging and multiscale modeling of distal radius bone fractures in patients and to investigate the in vivo healing process employing image processing and analysis. Bone fractures are very common and in 5-10% of the cases do not heal or are delayed. Nevertheless, factors influencing the healing outcome are not yet well understood. The specific aims of this 2-year project will therefore be (1) to perform high-resolution CT imaging in fracture patients and develop image analysis and registration methods to determine in vivo bone resorption and formation sites during fracture healing at the human distal radius, (2) to assess local bone remodeling and comparing the results with clinical biomarker measurements including whole bone strength through multiscale modeling approaches, and (3) to evaluate how bone remodeling during fracture healing affects whole bone strength in healthy, aged and osteoporotic humans.

The position will be based at the Inselspital Bern and at ETH Zurich. Furthermore, this project is embedded in a larger effort funded by the National Science Foundations of Switzerland, Germany, and Austria through a DACH consortium grant consisting of Ulm University (D), the Medical University Innsbruck (A), and the Inselspital Bern and ETH Zurich (CH). The overall goal of the consortium is to investigate local bone remodeling and mechanoregulation of bone fracture healing in healthy, aged, and osteoporotic humans.

The successful candidate holds or will soon receive a doctoral degree in Biomedical, Electrical or Mechanical Engineering, and has preferentially a background in imaging and image processing. It is essential that the candidate is willing and motivated to work at the interface between engineering and clinical research. Additionally, excellent communication skills in English (oral and written) are required and command of the German language is required for the clinical interactions.

We look forward to receiving your online application includinga a motivation letter, CV, university transcripts and names and contact details of two references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For further information about the group please visit our website www.bone.ethz.ch. Questions regarding the position should be directed to Dr. Patrik Christen by email patrik.christen[at]hest.ethz.ch (no applications).

Application:

https://apply.refline.ch/845721/6048/index.html?cid=1&lang=en

Postdoctoral Research Associate in Skeletal Ageing and Biomechanics at Insigneo

Postdoctoral Research Associate in Skeletal Ageing and Biomechanics at Insigneo

Job Title:
Postdoctoral Research Associate in Skeletal Ageing and Biomechanics

Description:
A position has become available for a highly motivated postdoctoral research scientist to be involved with studies to determine the effects of geroprotectors on bone and joint ageing.
You will use ex vivo X-ray microCT and histomorphometry combined with new computational approaches for an in depth structural analysis of bone, bone strength, cartilage degradation and subchondral bone changes.
The post is funded by Biotechnology and Biological Sciences Research Council (BBSRC) and will be based at the Insigneo Institute for In silico Medicine and the MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) in Sheffield.
You should hold a PhD in Engineering, Physics or related disciplines, be familiar with experimental, imaging, image processing and computational modelling techniques for assessment of bone properties. A willingness to learn histological techniques is also essential.
The post is fixed term until the end of December 2019, reporting to Dr Enrico Dall’Ara and Prof. Bellantuono

Contact: e.dallara@sheffield.ac.uk
Start position: As soon as possible
Duration: until the end of December 2019
Closing application: 25th January 2018
Link Application (use in Keywords: “UOS018139):
https://jobs.shef.ac.uk/sap/bc/webdy…ign=jobs-link#

Salary: Grade 7; £30,175 to £38,183 per annum