Blog Archives

PhD project on “Computational modelling of spinal growth and vertebral bone adaptation”

We are currently recruiting a PhD student for a project that was funded by the National Centre for Scientific Research (CNRS), France. The project deals with the development of a computational model to better understand spinal growth and bone adaptation. In particular, the project addresses the question how vertebral bodies grow under normal and pathological loading conditions such as in Adolescent Idiopathic Scoliosis (AIS), i.e. a spinal deformity that leads to abnormal vertebral loading, vertebral wedging and ultimately to a significant deformity of the spine. Furthermore, the altered loads on vertebral bodies may lead to a change in bone mass and re-orientation (i.e., adaptation) of the trabecular bone architecture which could play an important role for the development of osteoporosis at later stages in life. Access to longitudinal MRI data both from healthy and AIS subjects will allow for patient specific modeling of spinal growth and adaptation.

Candidates are expected to have a strong background in continuum mechanics and numerical simulations. A previous experience in a domain related to biomechanics and/or imaging techniques will be an asset.

The PhD project is a collaboration between Prof Vittorio Sansalone, Biomechanics team of the Multiscale Modeling and Simulation lab (CNRS UMR 8208), from the University of Paris Est Créteil (UPEC, France) and Professor Peter Pivonka, Director of Biomechanics and Spine Research Group, from Queensland University of Technology (QUT, Australia). The selected candidate will spend half of the time at UPEC, Paris and half of the time at QUT, Brisbane. The successful completion of PhD studies will lead to doctoral degrees both from the University Paris Est Créteil and Queensland University of Technology.

If you are interested in this position, please send your CV together with a cover letter to either Prof. Vittorio Sansalone (Email: vittorio.sansalone@u-pec.fr) or Prof. Peter Pivonka (peter.pivonka@qut.edu.au) by Friday, May 1, 2020.


PhD position in Computational Mechanics with an emphasis on Biomechanics and Piezoelectric Material

A PhD position shared in collaboration between the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin) and the Computational and Structural Mechanics group at the Institute of Mechanics in Technische Universität Berlin is vacant. 

Topic 

Bone has the ability to self-regenerate after injury, however, large bone defects often lead to delayed healing or non-unions. The treatment of these conditions remains a clinical challenge. To overcome the limitations of current bone treatment options, novel alternatives hold promise as the next generation of tissue engineering scaffolds. Experimental trial and error in the design of these scaffolds could be reduced by the development of a computer platform that could support the design of these scaffolds. The project therefore aims to develop suitable numerical models to investigate the behaviour and optimal design of tissue engineering scaffolds and their influence on the bone regeneration process. 

Your tasks 

You will employ engineering, mathematical and computational techniques (FEM) to determine the mechanical and electrical signals generated due to the physiological stimulation of a scaffold and to investigate how these signals influence the bone regeneration process. You will also investigate how different parameters influence the bone healing process. Using this understanding, the potential design optimization of scaffolds (concerning scaffold geometrical and material properties) will be also investigated. You have to be able to employ experimental data available to validate and qualify the numerical prediction. 

Your profile 

 Highly motivated candidate with a Master’s or comparable degree in mechanical engineering/biomedical engineering/material science and engineering/mathematical biology or a related discipline 

 Strong skills in Finite Element Modelling (e.g. Abaqus) 

 Ideally knowledge or experience in material science in particular piezoelectric materials 

 Knowledge in Programming is advantageous (e.g. C/C++, Matlab, Python) 

 Willingness to work in a multidisciplinary project 

 Very good English language skills (oral and written) 

What we provide 

This position is fully funded by the German Research Foundation (DFG) for a period of three years (100%, E13 salary group). You will work in friendly teams of highly qualified researchers and in unique research environments. Expected start date is at the earliest convenience, ideally May 1st, 2020. 

Application / Contact 

Please submit your application before March 31st, 2020 via e-mail to Dr. Melika Mohammadkhah (Melika.mohammadkhah@tu-berlin.de). Your email should contain a single PDF document (subject: “Application: PhD position”) including the letter of motivation, your CV (with contact information of at least two references), transcripts of the bachelor’s and master’s diploma, proof of English language skills. 

Call for ESB Mobility award 2020

The ESB is happy to announce the call for the Mobility awards 2020.

The ESB Mobility Grant aims to provide ESB members with financial assistance to carry out collaborative research in a foreign country as part of their PhD or postdoctoral research. The applicant and the scientist responsible of the host laboratory must be ESB members in good standing for at least 6 months.

The application deadline is 30th June 2020 and the winners will be announced in August.

This year we have added at least one award dedicated to senior postdocs that is added to standard awards given to PhD students or junior postdocs.

There are at least three awards available for 2020 on a competitive basis:

-) Junior Awards: at least two awards for PhD students or postdocs maximum one year after receiving their PhD degree;

-) Senior Awards: at least one award for postdocs between 2 and 5 years after receiving their PhD degree.

More details about the application can be found here:

Senior Scientific Officer in X-ray Microscopy

Faculty of Technology

School of Mechanical and Design Engineering

Senior Scientific Officer in X-ray Microscopy

ZZ003837

Information for Candidates

THE POST

Please see the attached job description and person specification.

THE TERMS OF APPOINTMENT

Full-time

Permanent

The School of Mechanical and Design Engineering at the University of Portsmouth wishes to recruit a Senior Scientific Officer in X-ray microscopy. The role will be based within the Future Technology Centre and support X-ray microscopy at the Zeiss Global Centre (ZGC), including two Versa 510 and 520 microscopes as well as associated techniques such as extensive in situ facilities and digital resources. Further details of the facility can be found at https://www.port.ac.uk/research/research-centres-and-groups/zeiss-global-centre

The ZGC is at the forefront of advanced X-ray microscopy, particularly coupled with techniques such as in situ mechanics and digital volume correlation (DVC), for which is considered one of the reference centres in UK and abroad. The ZGC has an international reputation in producing high-impact academic outputs, securing significant external income and providing opportunities for collaborations across multiple disciplines within the university as well as nationally and internationally. Specific areas of excellence include imaging-based understanding of complex structures, bioengineering, bioinspiration and imaging-additive manufacturing relationships.

The successful candidate should have a strong background in one or more of the following areas: X-ray microscopy, mechanical behaviour of structures, image analysis and digital volume correlation (DVC). The ZGC has a number of external partners and strategic links, and the position is expected to contribute to maintaining and growing these links. Additionally, the post holder is strongly encouraged to develop his/her own research area.

We welcome applications from all qualified applicants, but applications are particularly encouraged from traditionally under-represented groups in science and engineering. The University of Portsmouth holds an Athena Swan bronze award and is committed to introduce organisational and cultural practices that promote gender equality and create a better working environment for men and women.

For informal enquiries about the post please contact Dr Gianluca Tozzi at gianluca.tozzi@port.ac.uk or phone +44 (0)23 9284 2514.

For Applications:

https://www.jobs.ac.uk/job/BYX407/senior-scientific-officer-in-x-ray-microscopy

14 PhD scholarships within exciting ITN project!

Mediate – The Medical Digital Twin for Aneurysm Prevention and Treatment

https://cordis.europa.eu/project/id/859836/it

MeDiTATe aims to develop state-of-the-art image based medical Digital Twins of cardiovascular districts for a patient specific prevention and treatment of aneurysms. The Individual Research Projects of the 14 ESRs are defined across five research tracks:
(1) High fidelity CAE multi-physics simulation with RBF mesh morphing (FEM, CFD, FSI, inverse FEM)
(2) Real time interaction with the digital twin by Augmented Reality, Haptic Devices and Reduced Order Models
(3) HPC tools, including GPUs, and cloud-based paradigms for fast and automated CAE processing of clinical database
(4) Big Data management for population of patients imaging data and high fidelity CAE twins
(5) Additive Manufacturing of physical mock-up for surgical planning and training to gain a comprehensive Industry 4.0 approach in a clinical scenario (Medicine 4.0)


The work of ESRs, each one hired for two 18 months periods (industry + research) and enrolled in PhD programmes, will be driven by the multi disciplinary and multi-sectoral needs of the research consortium (clinical, academic and industrial) which will offer the expertise of Participants to provide scientific support, secondments and training. Recruited researchers will become active players of a strategic sector of the European medical and simulation industry and will face the industrial and research challenges daily faced by clinical experts, engineering analysts and simulation software technology developers. During their postgraduate studies they will be trained by the whole consortium receiving a flexible and competitive skill-set designed to address a career at the cutting edge of technological innovation in healthcare. The main objective of MeDiTATe is the production of high-level scientists with a strong experience of integration across academic, industrial and clinical areas, able to apply their skills to real life scenarios and capable to introduce advanced and innovative digital twin concepts in the clinic and healthcare sectors.

For application to 12 already available ESR positions please visit:
https://euraxess.ec.europa.eu/site/search?keywords=meditate

Three new fully funded PhD positions in soft biomechanics and medical technologies at the University of Portsmouth

Three fully funded PhD positions are currently available in the field of soft tissue biomechanics and medical technologies at the School of Mechanical and Design Engineering of the University of Portsmouth (UK).

All of the three projects arise from a close and strong collaboration between the research group of Biomechanics and local and national hospitals. They all have a strong drive in clinical practice, from which the underlying research question originates.

The first project is aimed to predict the artero-venus fistula outcome/evolution in patients undergoing hemodialysis; the second project is aimed to provide an in vivo measurement of heart valves deformation; the third project is focused on improving clinical practice for lesion detection and diagnosis in gastroscopy.

Further details about the three projects are available online at:

https://www.findaphd.com/phds/project/in-silico-assessment-tool-for-reducing-the-risk-of-failure-of-arterio-venous-fistula-avf-in-patients-subjected-to-haemodialysis/?p115898

https://www.findaphd.com/phds/project/investigating-the-physiological-deformation-of-heart-valves-using-in-vivo-and-in-vitro-techniques/?p115894

and
https://www.findaphd.com/phds/project/enhanced-endoscopic-screening-of-polyps-in-the-upper-gastrointestinal-tract/?p116271

Brilliant and ambitious students attracted by multidisciplinary subjects, interested in medical applications and strongly oriented to authentic teamworking are invited to apply.

The three positions are opened for UK/EEA applicants.

The deadline for the online application is Friday 23rd 2020. 

Post-doctoral researcher in Biomechanics at Uppsala University, specifically numerical analysis of injectable materials for spinal applications

Published: 2020-01-20

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Division for Applied Materials Science, Department of Materials Science and Engineering, the Ångström Laboratory.

The position is for two years starting as soon as possible. 

Tasks: The overarching goal is to evaluate different implant materials for spinal applications, and in particular their suitability for treatment of vertebrae and intervertebral discs.Mainly numerical methods will be used, such as finite element analysis, although some experimental work also will take place. A natural part of the work lies in reporting results, both in scientific journals and at conferences. The project is funded by the EU, and in particular EIT Health.

Qualifications required: To qualify for an employment as a post-doctor, the applicant must hold a PhD degree or a foreign qualification deemed equivalent to a PhD, and the PhD degree must have been obtained no more than three years prior to the application date; however, for example, periods of sick leave or parental leave are deducted from the three-year period.

For this position a PhD degree in engineering physics, mechanical engineering, biomedical engineering, or similar in nearby subjects, is required.

An interest in numerical modelling is a requirement, and experience in biomedical engineering is an advantage. The ability to lead and advance projects, as well as collaborative skills, is important.

Very good written and verbal skills in English is a must.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

For further information about the position please contact Professor Cecilia Persson, Cecilia.persson@angstrom.uu.se.

Salary: Individually negotiated salary.

Starting date: As soon as possible.

Type of position: Temporary position for two years.

You are welcome to submit your application no later than February 14 2020, UFV-PA 2019/4623. 

In case of disagreement between the English and the Swedish version of this announcement, the Swedish version takes precedence.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Please do not send offers of recruitment or advertising services.

Submit your application through Uppsala University´s recruitment system. More details:

https://www.uu.se/en/about-uu/join-us/details/?positionId=311258

4th ESB Webinar announced: “FEBio, a Nonlinear Finite Element Solver for Biomechanics “

We are delighted to announce the 4th webinar of the ESB Webinar Series which will introduce the FEBio Software Suite. The webinar will take place on March 30th 2020 at 17:00 CET.

This seminar has been co-organised by the ESB and VPHi student committees.


FEBio is a freely-available finite element solver designed specifically for solving problems in computational biomechanics and biophysics. This webinar on the FEBio software project will be focused mostly on new FEBio users and aims to:

  • Introduce FEBio and provide an overview of its capabilities.
  • Introduce FEBio Studio, a new integrated environment for setting up, running, and analyzing FEBio models.

At the end of this webinar, attendees will have learned the basic steps for working with FEBio and FEBio Studio, including how to:

  • Import surface and CAD geometry into FEBio Studio and generate FE meshes.
  • Set up boundary conditions, material parameters, and analysis settings.
  • Run the FEBio solver from within FEBio Studio.
  • Visualize and animate the FEBio results.

The webinar will be conducted by Dr. Steve Maas. He received his Master’s in Physics from the University of Antwerp, Belgium, in 2002 and his PhD in Computing from the University of Utah, USA, in 2017. Since 2005, he has been employed at the Musculoskeletal Research Laboratory at the University of Utah where he has been the lead software developer on the FEBio software project. FEBio is a finite element solver designed specifically for solving problems in computational biomechanics and biophysics. It accomplishes this by focusing on constitutive models, loading conditions, and modeling scenarios that are relevant to these research domains. Steve Maas has also created the PreView and PostView supporting software packages, which are used for pre-processing and post-processing, respectively, FEBio models. He is also the lead on the new FEBio Studio project, which is a fully integrated environment that combines many of the pre- and post-processing and solver capabilities, in a single unified interface.

The seminar will last 45 minutes followed by 15 minutes of Q/A from the audience. You will have the chance to ask your questions which will be addressed by the speaker at the end of the webinar. However, it would be great if you could send your question in advance while filling the registration form or by sending to Ehsan.soodmand@charite.de and/or rodrigo.romarowski@grupposandonato.it  before the start of the webinar.

Click here to register for the webinar.

Please Subscribe to our YouTube channel! (https://www.youtube.com/esbiomech ) and set a reminder for yourself via YouTube (https://www.youtube.com/watch?v=dFsosn8Cn0Y)

Looking forward to your attendance.

ESB Student Committee


PhD in Bath: Multiscale Analysis of the interactions between a Novel Total Artificial Heart and the Native Cardiovascular System

Project Description

Project team: Dr Katharine Fraser (k.h.fraser@bath.ac.uk) & Dr Andrew Cookson (a.n.cookson@bath.ac.uk)

Project
Over 500,000 people in the UK suffer from heart failure, with 14,000 admitted to hospital each year and 10,000 deaths. Worldwide, 26 million have heart failure, with a predicted increase of at least 46 % by 2030. The health expenditure on heart failure in the US alone is $31 billion. For patients with severe end-stage heart failure the only hope of long term survival is a heart transplant. However, donor hearts are scarce, resulting in fewer than 200 heart transplants/year in the UK. Alternative treatments are urgently needed to keep patients alive until a donor heart can be found. One alternative is a Total Artificial Heart (TAH): a machine to completely replace the native heart. Unfortunately, the only TAH on the market suffers from several issues.

Scandinavian Real Heart AB are developing a TAH with a completely novel pumping concept based on displacement of a piston and valve. It is hypothesized that the use of positive displacement, rather than rotation, has major advantages for physiological compatibility. This project will then investigate the interactions between the mechanical device and the native cardiovascular system, with the overall aim of assessing the biocompatibility of the device to aid design optimisation and regulatory approval. Specifically, the aims are to quantify the level of blood damage caused by the TAH, and find the effect of pulse wave it generates on the human arterial system.

The research will involve:
• the use of computational fluid dynamics to simulate blood flow within the Real Heart
• the development of numerical models for damage to the different blood cells
• the use of mathematical modelling to investigate pulse waves in the arteries
There is also the opportunity to perform experimental validation of the numerical results.

Through this PhD the student will become an expert in computational and mathematical modelling of fluid flows, including commercial and opensource software, and in-house code development. By working with Real Heart the student will develop teamwork and communication skills; to strengthen these the student will be based with the company in Sweden for 3 months. The University’s DoctoralSkills training includes a wide range of transferable skills courses. The student will write high impact journal papers and present at leading international conferences. Healthcare technology and biomedical devices are rapidly growing industries; a PhD in this area would equip the student with sought after skills and qualify them for a range of opportunities.

This project is an outstanding opportunity to help bring the next generation of mechanical heart pumps to the clinic. In addition, the research will contribute to fundamental science in incompressible fluid mechanics, blood trauma, and arterial dynamics, and develop new simulation techniques to advance the field of mechanical circulatory support development.

Candidate:
The successful applicant will ideally have graduated (or be due to graduate) with an undergraduate Masters first class degree or very good 2:1 or MSc distinction (or equivalent). English language requirements must be met at the time of application to be considered for funding.

More Details:

https://www.findaphd.com/phds/project/multiscale-analysis-of-the-interactions-between-a-novel-total-artificial-heart-and-the-native-cardiovascular-system/?p110261

Application:
Formal applications should be made via the University of Bath’s online application form for a PhD in Mechanical Engineering. Please ensure that you state the full project title and lead supervisor name on the application form.

https://samis.bath.ac.uk/urd/sits.urd/run/siw_ipp_lgn.login?process=siw_ipp_app&code1=RDUME-FP01&code2=0014

A full application must be submitted by the application deadline, including all supporting documents, to enable review.

More information about applying for a PhD at Bath may be found here:

http://www.bath.ac.uk/guides/how-to-apply-for-doctoral-study/

Anticipated start date: Monday 30 March 2020

Funding Notes

Funding is for up to three and a half years. It includes UK/EU tuition fees, training support fee of £1,000 per annum and a Maintenance stipend of £15,009 per annum (2019/0 rate). EU students are eligible to apply if they have been resident in the UK for 3 years prior to the funding commencing.