Blog Archives

PhD position on the characterization of anticipatory neuromuscular coordination during explosive movements @ University of Poitiers, France

We invite applications for a PhD position at University of Poitiers, France, entitled “Characterization of anticipatory neuromuscular coordination during explosive movements“.

Summary: The objective of this PhD thesis is to characterize anticipatory muscular coordination during iexplosive movements performed by trained female and male athletes. The Ph.D. student will conceive experimental protocols where human participants have to perform explosive dynamic movements. Data will be collected using both human motion analysis (infrared cameras & force sensors) and muscular physiology (electromyography & superfast ultrasound echograph) equipment. Anticipatory neuromuscular coordination recorded during explosive movements will then be analysed using multi-scale and multi-physic models. Joint torques and muscular lengths and activation patterns will be estimated from a personalised musculoskeletal model. Data collected with echographs will help refine the characterization of interactions between muscular and tendinous fibers.

Keywords: Human movement, Biomechanics, Neuromuscular coordination, Motion Analysis, Musculoskeletal Modelling, Experimental studies, Sport.

Supervisors: Dr. Floren COLLOUD & Dr Romain TISSERAND

Calendar:

Applications must be sent by email before April, 20th 2021.

Interview: from May 17th to May 21st 2021.

Project and funding will start October 1st 2021.

Further information: https://www.u-ldevinci.fr/simme/en/2021/03/04/characterisation-of-anticipatory-neuromuscular-coordination-during-explosive-movements/

For informal discussion please contact Floren Colloud (floren.colloud@univ-poitiers.fr)

Associate professor of Mechanobiology @ Mines Saint-Etienne – France

A permanent position of associate professor in mechanobiology is opened at Mines Saint-Etienne (France). Research will be developed at Sainbiose laboratory and will focus on experimental methods to study biological and mechanical evolution of tissues in the osteoarticular or cardiovascular systems.

More information and application at https://institutminestelecom.recruitee.com/o/concours-maitre-assistant-en-mecanobiologie

Application closure is April 23th 2021.

PhD Position in Experimental Micro- and Nanobiomechanics

We invite applications for a of a PhD position (University Assistant) in experimental micro- and nanobiomechanics. The position is set within a vibrant research group with a main focus on mechanics of individual collagen fibrils and micromechanics of collagen-rich tissues. The research project to be addressed is two-fold:

1) Further development of experimental testing devices for micro- and nanomechanical characterization of individual collagen fibrils and microscopic tissue samples. This is based on a unique mechanical testing device for nanoscale fibres.

2) Conducting scientific research on the mechanics of individual collagen-fibrils as well as micro-mechanics of tissue sections as a function of age, pathology or chemical modification. We have a number of ongoing research projects in this context such that this part will be shaped according to the interests of the applicant.

Further information and link to apply for this position (deadline March 4th 2021): https://jobs.tuwien.ac.at/Job/145238

For informal discussion please contact Philipp Thurner (Philipp.thurner@tuwien.ac.at)

Postdoc position on multiscale soft tissue mechanics using SAXS and Tomography

The institute of Bioengineering at Queen Mary University of London (QMUL) is seeking to appoint a Postdoctoral Research Assistant to couple synchrotron small-angle X-ray scattering (SAXS) and phase-contrast micro-tomography (pCT) to enable 3D imaging of fibrillar collagenous tissue in organs like joints and intervertebral discs. The bioengineering challenge is to determine the correlated 3D deformation and structural changes at the molecular-, fibrillar-, and cell-matrix length-scales under physiological load in intact tissue, and how these alter in ageing, injury and disease.

The position will be based on the Harwell Campus at Diamond Light Source (DLS), and is part of an international EPSRC-funded project (Tomo-SAXS) between QMUL, DLS, University College London, University of Manchester, and the European Synchrotron Radiation Facility.

More information can be found at: Postdoctoral Research Assistant – QMUL24137, https://tinyurl.com/y4y3lcrw

Four PhD Positions at ETH Zurich: MSCA ITN “BioTrib”

Four collaborative PhD positions are available at the Institute for Biomechanics (Department of Health Sciences and Technology). The Institute for Biomechanics is a multidisciplinary research unit dedicated to the biomechanical investigation of the human body. We investigate the mechanics and material properties of the musculoskeletal system, as well as movement control, from a macroscopic (body/organ) scale to a microscopic (cell) scale.

Project background

The available position is funded under the EU MSCA Innovative Training Network program “BioTrib”. The overall aims of the research program are to develop advances in the performance of natural and artificial joints. The program’s focus is on biotribology, which includes friction, lubrication and wear in these interventions. The researchers will gain the necessary interdisciplinary skills demanded by industry to deliver timely and cost-effective solutions to some of the most intractable European healthcare problems in arthritis.

Job description

The focus of each research sub-project is outlined in the job advertisement on the central ETH Zurich website listed below:

PhD Position: Design of a Self-Lubricating Prosthesis

https://jobs.ethz.ch/job/view/JOPG_ethz_mSUhxGFtq3OxYXYBoq

PhD Position: Boundary Lubrication of Fibrous Scaffolds

https://jobs.ethz.ch/job/view/JOPG_ethz_ZLaGSe9E6PBvQAY5q8

PhD Position: Tribological Characteristics of Nanofibrous Electrospun Materials

https://jobs.ethz.ch/job/view/JOPG_ethz_3H36CzKCMLpSTlxx7Q

PhD Position: Elucidation of Friction-Induced Failure Mechanisms in Fibrous Collagenous Tissues

https://jobs.ethz.ch/job/view/JOPG_ethz_Pbfuiq745SbJSXvWw8

Your profile

You are required to have a master’s degree in a relevant field. Specific requirements for each position are given in the individual job advertisements linked above.

Eligibility is set by the regulations of the MSCA ITN framework. Researchers can be of any nationality. They are required to undertake physical, transnational mobility (i.e. move from one country to another) when taking up their appointment. Therefore, researchers must not have resided or carried out their main activity (work, studies, etc.) in Switzerland for more than 12 months in the 3 years immediately before the recruitment date. The first positions are available from August 2021.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

Interested?

We look forward to receiving your online application with the following documents:

  • Covering letter with statement of motivation
  • CV
  • Copy of bachelor and master transcripts
  • Copy of MSc thesis

Please note that we exclusively accept applications submitted through our online ETH Zurich application portal linked above. Applications via email or postal services will not be considered. Application deadline is 28.02.2021.

Further information about the Institute for Biomechanics can be found on our website www.biomech.ethz.ch. Questions regarding the position should be directed to Prof. Stephen Ferguson, email sferguson@ethz.ch (no applications).

PhD position on crumbling reefs: simulation based monitoring of coral reefs @Heriot-Watt University

The project aims to develop computational models to analyse the impact of ocean acidification on cold-water coral reefs. Our vision is to facilitate rapid monitoring strategies that can help to preserve some of the most vulnerable ecosystems. To realise this, we aim to develop fast and effective multiscale in silico models from coral skeleton to reef length scale to predict the ocean acidification induced decay of cold-water coral reef systems. A major challenge is the ability to such complex systems, and we aim to overcome this by combining the power of multiscale models based on physical knowledge with the speed of artificial neural networks.

More information can be found here:

https://www.findaphd.com/phds/project/eps2021-27-crumbling-reefs-simulation-based-monitoring-of-coral-reefs/?p128407

PhD position on fast and effective personalised multiscale modelling for precision medicine in musculoskeletal diseases @Heriot-Watt University

Motivated by the pressing need for treatment optimisation in musculoskeletal diseases, our vision is to create a clinical point-of-care test that uses X-rays to visualise mechanical analyses of long bones such as the femur to illustrate potential therapeutic success in a couple of minutes, without adding significant time to patient consultations or training needs for clinicians. To realise this, we aim to develop fast and effective patient-specific in silico models to predict the multiscale mechanical behaviour of long bones. These combine the power of multiscale models based on physical knowledge with the speed of artificial neural networks.

More information can be found here:

https://www.findaphd.com/phds/project/eps2021-28-fast-and-effective-personalised-multiscale-modelling-for-precision-medicine-in-musculoskeletal-diseases/?p128413

2 PhD positions to advance integrated computational simulations of intervertebral disc degeneration

Lower back pain (LBP) is the largest cause of morbidity worldwide, yet there remains controversy as to the specific cause leading to poor treatment options and prognosis. Intervertebral disc degeneration (LDD) is reported to account for 50% of LBP in young adults, but the interplay of factors such as genetics, environmental, cellular responses, social and psychological is poorly understood. Unfortunately, the integration of such data into a holistic and rational map of degenerative processes and risk factors has not been achieved, requiring the creation of professional cross-competencies, which current training programmes in biomedicine, biomedical engineering and translational medicine fail to address, individually.

Disc4All aims to tackle this issue through collaborative expertise of clinicians; computational physicists and biologists; geneticists; computer scientists; cell and molecular biologists; microbiologists; bioinformaticians; and industrial partners. It provides interdisciplinary training in data curation and integration; experimental and theoretical/computational modelling; computer algorithm development; tool generation; and model and simulation platforms to transparently integrate primary data for enhanced clinical interpretations through models and simulations. Complementary training is offered in dissemination; project management; responsible research and innovation; ethics; regulation; policy; business strategy; public and patient engagement. Disc4All will train a new generation of internationally mobile professionals with unique skill sets for the development of thriving careers in translational research applied to multifactorial disorders.

Position 1:

Topic: Multiscale modelling of IVD cell activity & potential tissue turnover

Description: The successful candidate will work on the multiscale modelling of the mechanisms of intervertebral disc regulation. Specifically, the work will target the modelling and simulation of bottomup processes of tissue regulation, through which the dynamics of cell activity contributes to disc tissue turnover in specific regions of interest, in response to multifactorial cell stimulations. Different types of intervertebral disc network models will be used and combined to successively incorporate cell culture experimental data, proteomics measurements and eventually gene variant effects. Interplays of biochemical, mechanical and nutritional cell stimulation will be modelled in representative volume elements through agent-based modelling. Eventually, collective cell activity will be linked with heterogeneous cell environments predictable through finite element simulations of disc tissue and organ multiphysics.

Supervision: Jérôme Noailly (UPF)

More information:


Position 2:

Topic: Bottom-up simulations of spatio-temporal degenerative events in the IVD & biological LDD stratification

Description: The successful candidate will work on the systematization of multiscale modelling of the intervertebral disc regulation for improved LDD stratification. Existing regulatory network and multiphysics models, at the molecular/cell and tissue/organ scales will be locally integrated in relevant regions of interest of the IVD. Such integration will be coupled with different disc model morphologies and molecular signature inputs, from the Twins UK and Northern Finland Birth cohorts. A smart atlas of simulated data will be generated, to eventually enable efficient calculations through metamodeling. Metamodeling will further allow the mining of simulated and real word data altogether, to establish different fingerprints of LDD and the spatio-temporal evolution thereof, characterised by specific hierarchies of risk factors and exploitable clinically.

Supervision: Jérôme Noailly (UPF)

More information: