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PhD positions on biomechanics @ University of Bologna

Alma Mater Studiorum – University of Bologna (Italy) invites applications for the admission to the 38th PhD programme in Health and Technologies. (https://www.unibo.it/en/teaching/phd/2022-2023/health-and-technologies). 

The research projects about biomechanics cover in silico methodologies, deep learning, experimental and computational characterization of biological tissues and biomaterials, and imaging techniques.  Among the research projects advertised, you will find:

– I-BLOSSOM – Instrumented Biomarkers for LOngitudinal aSSessment Of Motor control development (Supervisor: Prof Stagni, rita.stagni@unibo.it)

– Development and perspective validation of an in silico methodology for the prediction of bone fracture risk to be used as clinical support system (Supervisor: Prof. Viceconti, marco.viceconti@unibo.it)

– Biomechanical evaluation of knee mechanical behaviour and interface stresses with a new concept of alignment for total knee arthroplasty (NEW- KNEE) (Supervisor: Prof. Cristofolini, luca.cristofolini@unibo.it)

– Computational modelling of vertebrae affected by metastasis for clinical diagnosis (Supervisor: Prof. Cristofolini, luca.cristofolini@unibo.it)

PhD candidates are expected to operate in a multidisciplinary team of engineers, biomaterials science, medical physics, computer science, biologists and clinicians. Each project will be conjointly supervised by a supervisor active in the technology field and one in the clinical field.

More details can be found in (https://www.unibo.it/en/teaching/phd/2022-2023/attachments/38th-cycle-phd-programme-table-health-and-technologies/@@download/file/38_PhD%20Programme%20Table_Health_Technologies.pdf). 

The online application must be submitted by June 9th, 2022 at 11.59 pm (CEST).

Three totally founded PhD scholarships are available.

If you would like to apply, contact the coordinator of the PhD programme (prof. Marco Viceconti, marco.viceconti@unibo.it) or the supervisor of the project you are interested in and join the University of Bologna for a wonderful research experience.

Tenure track (junior professorship) in tissue Biomechanics @LMGC, University of Montpellier

As part of the development of research activities in biomechanics and teaching activities in mechanical engineering, the University of Montpellier is recruiting for a non-permanent position of junior research professor in soft tissue biomechanics. Through here/his project, she/he will increase our knowledge and understanding of poro-elastic fibrous tissues (with a focus on cartilages) and of the contact mechanisms between those tissues in joints. Understanding these behaviors, including fluid-structure mechanisms could lead to (i) better understanding of the mechanobiological behavior and growth of cartilage and (ii) better understanding and modeling of contact mechanisms within joints and thus propose strategies for rehabilitation. Robotic solutions, different imaging modalities (US, MRI, microCT, microsopy,…), biosensors and 3D bioprinting may be developed/used in here/his research project, with the help of collaborative research between labs of the University.

More information:

http://www.lmgc.univ-montp2.fr/spip.php?article275&lang=fr

Senior Scientist position human movement biomechanics @TU Wien

Senior Scientist and head of newly built and equipped human movement lab staff position for a biomechanical engineer with mechanical/mechatronics engineering background and interest in Human Movement Biomechanics and development of assistive devices, available at Vienna University of Technology. The position is initially limited to two years, extension to permanent position possible.

More information: https://www.ikp.tuwien.ac.at/biomech/news/EN/

Postdoctoral researcher position on articular cartilage developmental biomechanics @University College Dublin

A postdoctoral researcher position is available in the Developmental Biomechanics Group. The research project is focussed on cartilage development and healing, and will be in close collaboration with Prof Pieter Brama from the UCD School of Veterinary Medicine. Experimental (wet lab, e.g., histology) experience (ideally) with musculoskeletal tissues is essential for the position. The funding available is for nine months, but every effort will be made to extend the duration of the position. The start date is asap, and latest July 2022.

More information: https://developmental-biomechanics.org/contact/

If interested in the opportunity, or for further enquiries, please email Prof Nowlan (niamh.nowlan@ucd.ie) your CV in the first instance. 

Open Position: University Assistant in Biomechanics and Proteomics @TUWien

The Institute of Lightweight Design and Structural Biomechanics (ILSB) of TU Wien invites applications for the position of a University Assistant (30h/week) in the area of biomechanics and proteomics. The successful candidate will conduct research towards a PhD thesis. In particular he/she will investigate healthy and degenerated meniscal tissue micro- / nano-mechanics using atomic force microscopy, spatially resolved micro-indentation and dedicated existing custom-made devices. Composition will be investigated via spatially mass-spectrometry methods under supervision of Prof. M. Marchetti-Deschmann of the Institute of Chemical Technologies and Analytics of TU Wien. After successfully establishing correlated mechanics and compositional datasets, a further step would be to compare retrieved data, to chemical magnetic resonance images (MRI) available through a clinical partner. In the long run we envision this to become a tool for early detection of meniscal degeneration and osteoarthritis.

More information:

PhD position on cardiac tissue growth & remodeling @TUDelft

Heart failure is a progressive chronic condition under which heart tissues undergo detrimental changes in structure and function across multiple scales in time and space. Given the role that biomechanical stimuli play in the onset and progression of these remodeling processes, cardiac restraint devices are seen as a promising treatment strategy. However, given the limited understanding of the underlying cardiac tissue behavior, current designs fail to successfully counteract pathological remodeling in the long term.

To this end, the aim of this PhD project is to develop, implement, verify, calibrate, and validate a microstructurally and functionally informed cardiac tissue model for growth and remodeling using finite element analysis. The outcomes of the developed framework will be leveraged to design enhanced bio-informed cardiac restraint devices.

Within this project, the PhD candidate is expected to operate within a multidisciplinary team of engineers, biomedical scientists, and cardiac surgeons. The outcomes of this project will be disseminated to the scientific community and to a general audience through presentations at (inter-)national conferences and through publications in peer-reviewed journals. Additionally, the candidate is expected to take part in educational activities within the department (assist in teaching, act as a mentor for master students, supervise master thesis work, … ).

The PhD candidate will be supervised jointly by dr. ir. M. Peirlinck (dept. of Biomechanical Engineering) and dr. ir. Noël (dept. of Precision & Microsystems Engineering) at Delft University of Technology. Our labs have a strong network of national and international collaborators in both academia and industry.

More information:

https://www.tudelft.nl/over-tu-delft/werken-bij-tu-delft/vacatures/details/?nPostingId=2429&nPostingTargetId=6179&id=QEZFK026203F3VBQBLO6G68W9&LG=UK&mask=external

PhD position on the prestress exerted by the fascia on muscle tissue @LBMC, Lyon, France

The Laboratory of biomechanics and impact mechanics, in Lyon (France) has a PhD position on the Experimental analysis and modeling of the prestress exerted by the fascia on muscle tissue. Numerical human body models are an important tool for better understanding the phenomena involved in mobility or comfort. In order to be able to model movement, deformable models of the human body must properly reproduce muscle activation. The main objective of this thesis topic is to include the fasciae, in particular the fascia lata at the level of the thigh, in the lower limb model developed at the LBMC to improve its biomechanical response during muscular activation.

To meet this objective, fascia mechanical properties must be mathematically modeled with a constitutive law of the material to be integrated in the lower limb model, and the prestressing exerted by the fascia on muscle tissue should also be quantified and modeled.

Full description of the project in both French and English: https://lbmc.univ-gustave-eiffel.fr/fileadmin/redaction/LBMC/Documents/Theses2022/sujet_de_These_LBMC_Fascia_2022_Bruyere_Gras_VF.pdf

If you would like to apply or need more information, please send CV, cover letter, contact information for a recommendation, and masters transcripts to Laure-Lise GRAS (laure-lise.gras@univ-lyon1.fr).

Open position of Associate Professor in data-driven mechanics of living material @Mines Saint-Etienne

Mines Saint-Etienne (MSE), one of the graduate schools of Institut Mines Télécom, the #1 group of graduate schools of engineering and management in France under the supervision of the Ministry of the Economy, Industry and Digital Technology, is assigned missions of education, research and innovation, transfer to industry and scientific, technological and industrial culture.

MSE consists of 2,400 graduate and postgraduate students, 400 staff, a consolidated budget of €46M, three sites on the Saint-Etienne campus (Auvergne Rhone-Alpes region, Lyon Saint-Etienne metropolitan area), a campus in Gardanne (SUD region, Aix Marseille metropolitan area), a site in Lyon within the digital campus of Auvergne Rhone-Alpes Region, six research units, five teaching and research centres and one of the leading French science community centres (La Rotonde €1M budget and +40,000 visitors per year). The Times Higher Education World University Ranking ranked us for 2022 in the 251-300 range for Engineering and Technology.  Our work environment is characterised by high Faculty-to-Student, Staff-to-Faculty and PhD-to-Faculty ratios, as well as comprehensive state-of-the-art experimental and computational facilities for research, teaching and transfer to industry.

The CIS gathers 70 people, including 18 permanent teacher-researchers in industrial/computer engineering, biomechanics and process engineering around health applications: biotechnologies, tissue engineering, e-health, computer-assisted surgery, personalized medicine and patient pathways… Since its creation in 2004, the CIS has been representative of Mines Saint-Etienne’s ability to position itself as a leader in innovative fields such as Soft Tissue Biomechanics, Health Care Systems and Services Engineering, and Biomaterials and Inhaled Particles Engineering. The person recruited will also interact with the other centers of the School (SMS, SPIN, CMP in particular) in order to federate research and transfer actions in the field of biomechanics and bioengineering.

The SAnté INgénierie BIOlogie Saint-Etienne laboratory (SAINBIOSE, INSERM UMR 1059) brings together researchers from the CIS (biomechanics, biomaterials and bioengineering fields), the Jean Monnet University medical school, the Saint-Etienne University Hospital, Inserm and the Etablissement Français du Sang. The overall scientific objective of SAINBIOSE is a better understanding and innovative management of biostress in osteoarticular (LBTO team) and cardiovascular (DVH team) pathologies.

Biomechanics, both experimental and numerical, is a major transverse theme of SAINBIOSE, ranging from the modeling of the mechanical behavior of tissues to clinical and industrial applications, particularly with the textile sector. The dynamism of SAINBIOSE and the CIS in this field makes them world-class players today (ERC and other European funding, numerous international collaborations and industrial contracts). The approach developed is largely based on established skills in numerical simulation and identification of behavior laws. The study, monitoring and prediction of the biomechanical properties of soft tissues, or of their interactions with medical devices, are areas of excellence. An additional dimension, of very high added value, will be obtained by integrating artificial intelligence and data science.

Application deadline: April 15, 2022

More information:

Research Fellow position on Data-driven fitting for the next generation of prosthetic sockets @University of Southampton

Join an exciting interdisciplinary research team of biomedical engineers, prosthetists, physiotherapists, healthcare psychologists, social scientists and software engineers, who are developing a method of designing the bespoke prosthetic ‘socket’ interface between a person and their prosthetic limb, using artificial intelligence (AI) to interpret data from expert clinical designers. 

You will work primarily with academics at the University of Southampton (Dr Alex Dickinson, Dr Cheryl Metcalf, Dr Maggie Donovan-Hall and Dr Peter Worsley) on a project led by company partner Radii Devices Ltd (Dr Joshua Steer), with prosthetics service provider Opcare / Ability Matters Ltd.

Application deadline: Monday 28 February 2022

More information:

https://jobs.soton.ac.uk/Vacancy.aspx?ref=1700622DA&fbclid=IwAR1SKX7sFdqYbcG0_6nbBtzVteUZIWp9Ooul6aKXEwCwK6vtOmzS81hZBEE

Postdoc position on computational modeling of integrin signaling and cell-ECM interactions @Maastricht University

The department of Cell Biology-Inspired Tissue Engineering (cBITE) at the MERLN Institute for Technology-inspired Regenerative Medicine at Maastricht University in the Netherlands invites applications for a post-doctoral position. The post-doctoral researcher will perform cutting-edge research in computational modeling methods applied to regenerative medicine and more specifically, to cell-matrix interactions.

Regenerative medicine (RM) holds the promise to cure many of what are now chronic patients, restoring health rather than protracting decline, bettering the lives of millions and at the same time preventing lifelong, expensive care processes: cure instead of care. The scientific community has made large steps in this direction over the past decade, however our understanding of the fundamentals of cell, tissue and organ regeneration and of how to stimulate and guide this with intelligent biomaterials in the human body is still in its infancy. To date, the RM field has focused on studying cell-biomaterial interactions. Materials properties such as elasticity, topography, hydrophobicity, and porosity have all been shown to influence cell fate, and the introduction of high-throughput combinatorial approaches is expediting research and decoupling the properties to further inform the design of biomaterials. However, in order to improve the design of synthetic biomaterials, it is crucial to understand the physiological cell-ECM interactions and how these influence cell behavior. This research project aims to use in silico models to simulate cell-ECM interactions, improve our fundamental understanding thereof and use the obtained knowledge to design improved synthetic matrices.

Project description:

  • Computational modeling of integrin signaling, cell-ECM interaction to inform the design of synthetic matrices;
  • Parameter optimization and sensitivity analysis;
  • Analysis and integration of various in vitro/in vivo data for model calibration.

What we offer:

  • Computational ecosystem at Maastricht University: Institute for Data Science (IDS), Department of Knowledge Engineering (DKE) and Maastricht Centre for Systems Biology (MacsBio);
  • Excellent computational and experimental facilities to validate the in silico analyses and predictions in vitro/in vivo;
  • Interdisciplinary environment within MERLN and the “Materials-driven regeneration (MDR)-consortium”

Project embedding:

The project will be coordinated by the MERLN Institute for Technology-Inspired Regenerative Medicine (http://merln.maastrichtuniversity.nl/) as part of the “Materials-driven regeneration (MDR)-consortium” (see http://www.mdrresearch.nl/ for more information) which brings together an interdisciplinary team of excellent scientists at three leading institutes (ICMS at Eindhoven University of Technology, RMU at Utrecht University and MERLN at Maastricht University). The central goal of MDR’s research program is to investigate, design and use intelligent biomaterials that drive the functional regeneration of living tissues and organs under complex (patho)physiological conditions.

More information:

https://www.academictransfer.com/en/309006/post-doctoral-position-for-the-project-computational-modeling-of-the-cell-matrix-interface-at-the-department-of-cell-biology-inspired-tissue-engineering-cbite-at-the-merln-institute/

For more detailed information you can contact: dr. A. Carlier, email a.carlier@maastrichtuniversity.nl