PhD position on computational modeling of mechanically-driven sprouting angiogenesis @Charité

Background and scope of the work

Angiogenesis, the growth of new blood vessels from pre-existing vessels, constitutes a fundamental physiological process during the regeneration of many tissues, including bone. In a DFG-funded collaborative project, we are using a combined experimental/computational approach to investigate how mechanical forces mediate angiogenesis during bone repair. As part of this project, a PhD position is available to investigate the role of mechanical strains on the growth of new blood vessels using mechano-biological computational models.  

Tasks

You will develop computer models of sprouting angiogenesis taking into account the role played by chemical and mechanical signals in vessel patterning. You will work in close collaboration with project partners working in in vitro and in vivo models to inform and validate the computer models.

Your profile

  • Master Degree in Mechanical Engineering, Computational Biomechanics, Computational Biology or a related discipline
  • Strong programming skills
  • Knowledge of finite element analysis
  • High motivation, curiosity and commitment to scientific excellence
  • Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment
  • Excellent command in written and spoken English
  • Independent and responsible attitude, collaborative spirit

What we provide

This position is available for a period of three years with the possibility to be extended if new funding is available. You will work in a friendly team and in a unique research environment. As a PhD student, you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international scientists.

Starting date: as soon as possible.

Contact:

If you are interested, please send your CV, motivation letter and two references to: Prof. Sara Checa (sara.checa@charite.de)